TY - JOUR ID - 89048 TI - Correlation between HER2 Expression and Clinicopathological Features of Breast Cancer: A Cross- Sectional Study in Vietnam JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Dang Cong, Thuan AU - Nguyen Thanh, Tung AU - Nguyen Phan, Quynh Anh AU - Hoang Thi, Ai Phuong AU - Nguyen Tran, Bao Song AU - Nguyen Vu, Quoc Huy AD - Department of Histology, Embryology, Pathology and Forensic, Hue University of Medicine and Pharmacy, Hue University, Vietnam. AD - Faculty of Basic Science, Hue University of Medicine and Pharmacy, Hue University, Vietnam. AD - Department of Obstetrics and Gynaecology, Hue University of Medicine and Pharmacy, Hue University, Vietnam. Y1 - 2020 PY - 2020 VL - 21 IS - 4 SP - 1135 EP - 1142 KW - breast cancer KW - HER2 KW - immunohistochemistry KW - DISH KW - clinicopathological features DO - 10.31557/APJCP.2020.21.4.1135 N2 - Background: HER2 is the target of the therapeutic agents which are used to treat HER2-positive breast cancer. Reports have shown that the HER2 oncogene expression and its association with clinicopathological factors remain unclear in breast cancer (BC) patients.  This study aimed to determine the correlation between HER2 expression and clinicalpathological characteristics of breast cancer in Vietnamese women. Methods: Between June 2016 and August 2018, paraffin-embedded specimens from 237 patients with primary invasive breast carcinoma in Hue University Hospital and Hue Center Hospital, Hue city, Vietnam were examined for pathological features. The gene expression of HER2, ER, PR and Ki-67 were determined by immunohistochemistry (IHC). The gene amplification of Her2 was assessed by using Dual color in situ hybridization (DISH). Results: The most frequent histological type was invasive carcinoma of no special type (NST) with 77.35%, the highest percentage of patients with Grade II was detected (59.36%), tumor size > 2 cm accounted for 71.31% of cases, Lymph node metastases were available in 57.86% cases. Most patients were diagnosed at stage II (59.18%). The majority of patients were classified as moderate Nottingham prognostic index (54.9%). Estrogen receptor and Progesterone receptor were positive in 53.16% and 50.63%, respectively. 76.37% of cases were in high expression group of Ki-67 (≥14%). HER2 IHC 2+, 3+ were accounted for 28.69% and HER2 gene amplification was detected in 31% cases. HER2 gene amplification and/or overexpression was significantly associated with cell proliferation index Ki67. Furthermore, HER2 gene expression tended to be more frequently found in tumors with large tumor size, high grade, high stage and high Nottingham prognostic index and confirmed their prognostic independent role. Conclusions: Our data indicated that HER2 gene expression was significantly correlated with cell proliferation index Ki67, but not significantly associated with another clinicopathological factors in breast cancer of Vietnamese women.   UR - https://journal.waocp.org/article_89048.html L1 - https://journal.waocp.org/article_89048_936f2df9eccb02644daf0f32c1c8e1c9.pdf ER -