TY - JOUR ID - 89054 TI - Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Karimi-Zarchi, Mojgan AU - Abbasi, Hajar AU - Javaheri, Atiyeh AU - Hadadan, Amaneh AU - Meibodi, Bahare AU - Tabatabaei, Razieh Sadat AU - Ghelmani, Yaser AU - Neamatzadeh, Hossein AD - Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran. AD - Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Y1 - 2020 PY - 2020 VL - 21 IS - 5 SP - 1197 EP - 1206 KW - Cervical cancer KW - Cervix KW - interleukin KW - Polymorphism KW - Meta-analysis DO - 10.31557/APJCP.2020.21.5.1197 N2 - Background: Primary studies have shown that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms are associated with an increased risk of cervical cancer. However, conflicting results warrant a meta-analysis to obtain more precise estimates. Methods: A comprehensive literate search on PubMed, Web of Science, Scopus, CNKI, and SciELO was performed to collect all eligible studies up to November 10, 2019. The pooled odds ratios (OR) and 95% confidence intervals (CI) were used to calculate the risk. This meta-analysis was carried out by utilizing CMA software. Results: A total of eleven case-control studies including four studies on IL-12B rs3212227 and seven studies on IL-6 rs1800795 were selected. Pooled ORs revealed that the IL-6 rs1800795 polymorphism was significantly associated with an increased risk of cervical cancer (C vs. G: OR = 1.294, 95% CI 1.071-1.564, p= 0.007; CC vs. GG: OR = 1.633, 95% CI 1.059-2.520, p= 0.027; CC+CG vs. GG: OR = 1.312, 95% CI 1.048-1.643, p= 0.018; and CC vs. CG+GG: OR = 1.592, 95% CI 1.268-1.999, p≤0.001), but not IL-12B rs3212227 polymorphism. Stratified analysis by ethnicity revealed that both IL-12B rs3212227 and IL-6 rs1800795 polymorphisms were associated with risk of cervical cancer in Asian women. Conclusions: Our pooled data revealed that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms may be used to identify individuals at high risk of cervical cancer in Asian women.   UR - https://journal.waocp.org/article_89054.html L1 - https://journal.waocp.org/article_89054_f459924c1b1752ff0ff7a23f2b7cbf02.pdf ER -