TY - JOUR ID - 89059 TI - Aberrant Expression of miR-103, miR-184, miR-378, miR-497 and miR-506 in Tumor Tissue from Patients with Oral Squamous Cell Carcinoma Regulates the Clinical Picture of the Patients JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Ghffari, Maryam AU - Asadi, Milad AU - Shanaehbandi, Dariush AU - Bornehdeli, Soghra AU - Sadeghzadeh, Mahsa AU - Mohammad Reza Khani, Haniye AU - Ghasembaglou, Shahram AD - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Y1 - 2020 PY - 2020 VL - 21 IS - 5 SP - 1311 EP - 1315 KW - oral squamous cell carcinoma KW - miR-184 KW - miR-378 KW - MiR-497 KW - miR-506 DO - 10.31557/APJCP.2020.21.5.1311 N2 - Background: This study aimed to evaluate the expression patterns of miR-103, miR-184, miR-378, miR497 and in squamous cell carcinoma (SCC) of the tongue and to be compared with normal peripheral tissues. Methods: Tumor and marginal tissues were obtained from 50 patients with OSCC. After RNA extraction, expression level of miR-103, miR-184, miR-378, miR497, and miR506 was estimated using SYBR green master mix and real-time quantitative PCR. Results: It was observed that, there was no detectable difference in expression level of miR-103 between tumoral and marginal tissues. However, expression level of miR-184, and miR-378 showed significant increase in tumor tissue samples compared to marginal tissue samples. MiR-497 and miR-506 demonstrated considerable decrease in tumoral cells in comparison with peripheral tissues. Moreover, the expression level of miRNAs was associated with clinicopathological features of the patients. Conclusions: Our data indicated that miR-184, miR-378, miR-497, and miR-506 can be used as a potential diagnostic and prognostic biomarker in OSCC. Nevertheless, more studies are needed to confirm this claim.   UR - https://journal.waocp.org/article_89059.html L1 - https://journal.waocp.org/article_89059_388db3bc59e655e82c5bdf44b1ed19a3.pdf ER -