TY - JOUR ID - 89158 TI - miR-140 and miR-196a as Potential Biomarkers in Breast Cancer Patients JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Shahabi, Arman AU - Naghili, Behrooz AU - Ansarin, Khalil AU - Montazeri, Vahid AU - Zarghami, Nosratollah AD - Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Department of Thoracic Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Y1 - 2020 PY - 2020 VL - 21 IS - 7 SP - 1913 EP - 1918 KW - Biomarkers KW - miR-140 KW - miR-196a KW - Quantitative PCR KW - breast cancer DO - 10.31557/APJCP.2020.21.7.1913 N2 - Objective: MiR-140 and miR-196a were known to be correlated with cancer diagnosis and prognosis. The current study aimed at the analysis of miR-140 and miR-196a expression patterns and their clinical significance for breast cancer (BC) patients. Methods: Differentially expressed miR-140 and miR-196a were examined via quantitative PCR in 110 cases of BC and their adjacent non-tumor (ANT) tissues. Results: The results indicated that miR-140 and miR-196a, respectively, notably decreased and increased expression in BC samples in comparison with ANT (p<0.001). Reduced miR-140 expression was also related to Lymph node metastasis (LNM, P= 0.023) and stage (P = 0.009). Additionally, Receiver Operating Characteristics (ROC) analysis illustrated that miR-140 had a significant diagnostic accuracy for stage and LNM of BC patients. We also discovered a strong negative correlation between miR-196a expression with histological grade (P = 0.038), LNM (P = 0.012) and stage (P = 0.001). Conclusion: Overall, exploring the miR-140 and miR-196a profiles not only can statistically different among BC and ANT samples, but it is also expected to become potential BC biomarkers.   UR - https://journal.waocp.org/article_89158.html L1 - https://journal.waocp.org/article_89158_1cf907c06fecca7622fdd48989b8cab1.pdf ER -