TY - JOUR ID - 89209 TI - A Case-Control Study of Meat Mutagens and Colorectal Cancers in Viet Nam JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Dao, Hang Viet AU - Nguyen, Tu Thi Minh AU - Tran, Hoc Hieu AU - Dang, Linh Thuy AU - Dinh, Minh Thi AU - Le, Ngoan Tran AD - Hanoi Medical University, Hanoi, Viet Nam. AD - School of Biotechnology and Food Technology, Hanoi University of Science and Technology, Hanoi, Viet Nam. AD - Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Y1 - 2020 PY - 2020 VL - 21 IS - 8 SP - 2217 EP - 2223 KW - colorectal cancer KW - meat mutagens KW - Cooking method KW - Beef intake DO - 10.31557/APJCP.2020.21.8.2217 N2 - Objective: The aim was to examine the association between heterocyclic amines 2-amino-1-methyl-6-phenylimidazo pyridine (PhIP) and the risk of colorectal cancer (CRC) in Viet Nam. Methods: We performed a case-control study for 512 colorectal cancer patients with the histopathological confirmation and 1,096 hospital controls. We collected information on lifestyle, diet, and cooking methods from participants by trained interviewers using the validated questionnaires. We used data of PhIP concentration in cooked beef analyzed by the LC/MS/MS and cooking questionnaire to estimate the daily intake of PhIP. We divided the estimated amount of PhIP (ng/person/day) into three levels of non-intake (the reference), medium, and high to estimate the Odds ratio and 95% confidence interval (OR, 95%CI). Results: The median intake of PhIP (ng/person/day) was 18ng and 102.8ng for medium and high PhIP intake, respectively. There was a significant association between PhIP intake and the risk of colorectal cancer. The adjusted OR (95%C), high intake vs. non-intake, were 4.89 (3.03, 7.89), p_trend   UR - https://journal.waocp.org/article_89209.html L1 - https://journal.waocp.org/article_89209_aa19b1d3ab2124ff12dc60bf26625ba3.pdf ER -