TY - JOUR ID - 89253 TI - Increased Expression of Oct4, Nanog and CD24 Predicts Poor Response to Chemo-Radiotherapy and Unfavourable Prognosis in Locally Advanced Oral Squamous Cell Carcinoma JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Mishra, Sridhar AU - Tiwari, Vandna AU - Arora, Aditi AU - Gupta, Seema AU - Anand, Nidhi AU - Husain, Nuzhat AD - Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. AD - Department of Radiotherapy, King George Medical University, Lucknow, Uttar Pradesh, India. Y1 - 2020 PY - 2020 VL - 21 IS - 9 SP - 2539 EP - 2547 KW - oral squamous cell carcinoma KW - Oct4 KW - Nanog KW - CD24 KW - Cancer stem cells DO - 10.31557/APJCP.2020.21.9.2539 N2 - Background: Current study investigates the role of Oct4, Nanog and CD24 in locally-advanced oral squamous cell carcinoma (OSCC), to evaluate whether the expression of these markers can predict efficacy of neoadjuvant-chemo-radiotherapy and survival of patients. Methods: Biomarker expression was evaluated in 50 homogenously treated patients of locally-advanced OSCC. Results: Clinical response was complete in 30% (n=15), partial response in 46% (n=23), no response in 24% (n=12). Pathologically, 74% patents (n=37) were responders and 26% were non-responders (n=13). Biomarker-overexpression was seen in 46% cases for Oct4, 54% cases for Nanog and 58% cases for CD24. Oct4, Nanog and CD24 expression showed significant correlation with clinical and pathological response (p <0.05). Three year recurrence-free survival was 71%, overall survival was 66%. Post-treatment advanced pathological N (ypN), post treatment advanced pathological TNM (ypTNM) stage, clinical non-response, pathologic non-response, positive/high expression of all three biomarkers had a significant negative impact on recurrence-free and overall survival. Conclusions: Expressions of Oct4, Nanog and CD24 have significant association with treatment response and survival in patients with locally advanced OSCC treated with neoadjuvant chemo-radiation. Survival of these patients is significantly affected by ypN stage, ypTNM stage, expression of all three biomarkers, clinical and pathological response to neoadjuvant therapy.   UR - https://journal.waocp.org/article_89253.html L1 - https://journal.waocp.org/article_89253_acc6da3283237198c2754c68993285b2.pdf ER -