TY - JOUR ID - 89363 TI - Karnofsky Performance Scale and Neurological Assessment of Neuro-Oncology Scale as Early Predictor in Glioma JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Gunawan, Pricilla Yani AU - Islam, Andi Asadul AU - July, Julius AU - Patellongi, Ilhamjaya AU - Nasrum, Muhammad AU - Aninditha, Tiara AD - Department of Neurology, Faculty of Medicine, Universitas Pelita Harapan, Jl. M.H.Thamrin Boulevard 1100, Lippo Village, Tangerang 15811, Indonesia. AD - Department of Neurosurgery, Faculty of Medicine, Universitas Hasanuddin, Jl.Perintis Kemerdekaan KM 10, Makassar, Indonesia. AD - Department of Neurosurgery, Faculty of Medicine, Universitas Pelita Harapan, Jl. M.H.Thamrin Boulevard 1100, Lippo Village, Tangerang 15811, Indonesia. AD - Department of Physiology, Faculty of Medicine, Universitas Hasanuddin, Jl.Perintis Kemerdekaan KM 10, Makassar, Indonesia. AD - Molecular Biology and Immunology Laboratory, Faculty of Medicine, Universitas Hasanuddin, Jl.Perintis Kemerdekaan KM 10, Makassar, Indonesia. AD - Department of Neurology, Faculty of Medicine, Universitas Indonesia. Jl. Diponegoro No.71, Jakarta, Indonesia. Y1 - 2020 PY - 2020 VL - 21 IS - 11 SP - 3387 EP - 3392 KW - Functional Scale KW - KPS KW - NANO Scale KW - Glioma DO - 10.31557/APJCP.2020.21.11.3387 N2 - Objective: Glioma is one of the most frequent and disabling primary brain tumour. Patients are not only dealing with survival, but also quality of life, which remains another major concern. Karnofsky Performance Scale (KPS) is one of the most commonly used scale to assess patients’ quality of life. A recent scale, known as Neurological Assessment of Neuro-Oncology Scale, has surfaced to examine neurological disability caused by brain tumour. Previous study showed this scale to be superior to KPS in predicting survival. However, these scales have never been used to foresee functional scale improvement during disease progression. We sought to determine whether initial KPS and NANO Scale can predict functional scale improvement 2 months after surgery. Methods: Patients with glioma grade II-IV were included in the study. IDH mutation and MGMT methylation were tested. KPS and NANO scale were examined before surgery and 2 months after surgery. Favorable outcome (FO) was defined as improvement in functional scale 2 months after surgery. Patients initial functional scales were analyzed towards favorable outcome. Results: Glioma WHO grade II, III and IV was found in 17 patients (36.2%), 3 patients (6.4%) and 27 patients (57.4%) respectively. Median KPS before and 2 months after surgery were 50 (30-80) and 60 (0-100), whereas median NANO scale before and 2 months after surgery were 5 (0-12) and 3 (0-12). Favorable outcome was found in 63.8% (KPS) and 78.7% (NANO Scale). Patients initial functional scales were significantly related to FO. Conclusion: Good initial functional scales are 4 to 5 times likely of having a favorable outcome 2 months after surgery. UR - https://journal.waocp.org/article_89363.html L1 - https://journal.waocp.org/article_89363_53edb4016ab79709aaf1251e47cd2614.pdf ER -