TY - JOUR ID - 89402 TI - Do Protocadherins Show Prognostic Value in the Carcinogenesis of Human Malignant Neoplasms? Systematic Review and Meta-Analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Dutra, Thaís Torres Barros AU - Bezerra, Thâmara Manoela Marinho AU - Luna, Ealber Carvalho Macêdo AU - Carvalho, Francisco Samuel Rodrigues AU - Chaves, Filipe Nobre AU - Barros Silva, Paulo Goberlânio de AU - Costa, Fábio Wildson Gurgel AU - Pereira, Karuza Maria Alves AD - Department of Clinical Dentistry, Faculty of Pharmacy and Dentistry and Nursing, Federal University of Ceara, Fortaleza, Brazil. AD - School of Dentistry, Federal University of Ceara, Campus Sobral, Sobral, Brazil. AD - Departament of Morphology, School of Medicine, Federal University of Ceará, Brazil. Y1 - 2020 PY - 2020 VL - 21 IS - 12 SP - 3677 EP - 3688 KW - cancer biomarkers KW - carcinogenesis KW - Molecular biology DO - 10.31557/APJCP.2020.21.12.3677 N2 - Background: Protocadherins (PCDHs) have been reported as tumor suppressor genes, implying that these genes may be involved in tumor suppression in a variety of cancers. However, a thorough understanding of the functions and mechanisms of PCDHs remains limited. Our aim was to investigate the methylation profile of PCDHs in human malignant neoplasms. Methods: This systematic review has been recorded in PROSPERO (#42019117844) and conducted according to PRISMA’s checklist; search was conducted in LILACS, PubMed, Science Direct, Scopus, and Web of Science databases, manually, with search queries and without date or language restrictions. Results: We found 91 articles, of which 26 were used for this meta-analysis and categorized according to the origin of the neoplasia. In total, 3,377 cases were compiled, with PCDH10, PCDH17, and PCDH8 being the most studied; males were 2.22 times more affected than females. Studies have shown significant heterogeneity (p <0.001), with the odds ratio varying between cases and controls [2.20 (95% CI = 1.11– 4.35) to 209.05 (95% CI = 12.64– 2,457.18)], and the value of association between methylation and cancers studied was 26.08 (95% CI = 15.42–44.13). Conclusion: In this systematic review, we have demonstrated using meta-analysis that PCDHs could emerge as potential tumor suppressor genes and that a significant increase in methylation may be useful for early detection of different cancers. This work may help in the identification of new prognostic biomarkers in malignant neoplasms. UR - https://journal.waocp.org/article_89402.html L1 - https://journal.waocp.org/article_89402_ad50a1b6200898c001af519050588322.pdf ER -