TY - JOUR ID - 89622 TI - Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work? JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Gul, Aylin Ege AU - Keser, Sevinc Hallac AU - Barisik, Nagehan Ozdemir AU - Gurbuz, Yesim Saliha AU - Sensu, Sibel AU - Erdogan, Nusret AD - Health Sciences University, Kartal Lutfi Kirdar Research&Traning Hospital, Pathology Clinic, Istanbul, Turkey. AD - Pathology, Istınye University Medical Faculty, Turkey. Y1 - 2021 PY - 2021 VL - 22 IS - 6 SP - 1721 EP - 1729 KW - Pheochromocytoma KW - paraganglioma KW - SDHB KW - immunohistochemistry DO - 10.31557/APJCP.2021.22.6.1721 N2 - Background: In this study, we aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. Methods: A total 114 PPGL cases (73 HNPGL, 15 TAPPGL and 27 Pheo belonging to 112 cases) are included. Immunohistochemically, SDHB and Ki-67 are investigated and malignancy risks are determined by PASS classification. Results are assessed statistically with chi-square test and p <0,01 is considered significant.Results: SDHB mutations are observed in 20 of 114 (17.54 %) PPGL cases, 3 (11,12%) of which is Pheo, 12 (16,44) is HNPGL, and 5 (35,71%) is TAPPGL (P <0,02). While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to PASS classification, 5/32 (15,63%) cases has (p=0,73). TAPPGL, HNPGL and Pheo sub-groups have a significant difference between SDHB expression (p <0,02), malignancy potential according to PASS classification (p <0,0001) and Ki-67 proliferation index (p <0,0001). Conclusion: To identify patients for molecular pathological examination, routine application of SDHB immunohistochemistry to PPGL tumors are suggested especially in HNPGLs. UR - https://journal.waocp.org/article_89622.html L1 - https://journal.waocp.org/article_89622_95a1d33377c370b0ca4f413c8fcf253e.pdf ER -