TY - JOUR ID - 89885 TI - The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Ozdemir, Yesim AU - Cag, Murat AU - Colak, Emel AU - Coskun, Nuriye AU - Basgoz, Neslihan AU - Sarici, Hakan AU - Kaan, Dilek AU - Dogan, Muhammet AU - Deniz, Kemal AU - Inanc, Mevlude AU - Ozkul, Yusuf AD - Uskudar University, Medical Faculty, Medical Genetics Department, Umraniye, 34768 Istanbul, Turkey. AD - Université de Strasbourg, Service de chirurgie vasculaire et de transplantation, Nouvel Hôpital Civil, Université de Strasbourg 1 Place de l’Hôpital 67000 Strasbourg, France. AD - Erciyes University , Medical Faculty, Medical Genetics Department, 38280, Kayseri, Turkey. AD - Yozgat City Hospital,66100, Yozgat, Turkey. AD - Betul- Ziya Eren Genome and Stem Cell Center, 38280, Kayseri, Turkey. AD - Erciyes University, Medical Faculty, Pathology Department, 38280, Kayseri, Turkey. AD - Erciyes University, Medical Faculty, Oncology Department,38280, Kayseri, Turkey. Y1 - 2021 PY - 2021 VL - 22 IS - 12 SP - 3839 EP - 3846 KW - Colon cancer KW - Metastasis KW - Gene Mutuation DO - 10.31557/APJCP.2021.22.12.3839 N2 - Objective: It is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers. Methods: A total of 50 patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 were included in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53, PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next generation sequencing method. The effect of gene mutations on metastasis and overall survival were evaluated. Results: The mean age of patients with colon cancer without distant metastasis was 48.64±14.72 years and for patients with distance metases was 56.68±11.65. The mean survival time of colon cancer patients with distant organ metastasis after the metastasis date was 104.36±58.59 weeks. The presence of APC, MUTYH, and TP53 genetic mutations was observed with a higher rate in metastatic colon cancer (p<0.05). Conclusion: We showed that APC, MUTYH, and TP53 mutations are associated with distant organ metastasis.  UR - https://journal.waocp.org/article_89885.html L1 - https://journal.waocp.org/article_89885_05305447f2f4847e94f6ec79f9369930.pdf ER -