TY - JOUR ID - 89923 TI - Association between VDR Gene Polymorphisms and Melanoma Susceptibility in a Colombian Population JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Aristizabal-Pachon, Andres Felipe AU - Gonzalez-Giraldo, Yeimy AU - Garcia, Angela Yazmin AU - Suarez, Dalia Xiomara AU - Rodriguez, Angela AU - Gonzalez-Santos, Janneth AD - Department of Nutrition and Biochemistry, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá DC, Colombia. AD - University of Cundinamarca, Colombia. AD - Pedagogical and Technological University of Colombia. Y1 - 2022 PY - 2022 VL - 23 IS - 1 SP - 79 EP - 85 KW - cancer KW - Fok1 and Taq1 polymorphisms KW - PCR-RFLPs KW - rs2228570 KW - rs731236 DO - 10.31557/APJCP.2022.23.1.79 N2 - Background: The vitamin D receptor (VDR) is responsible for mediating the effects of vitamin D through regulation of other gene transcriptions. There are several polymorphisms that alter the gene expression or the function of this protein. We aimed to analyze the association between two SNPs  of VDR gene and melanoma cancer in Colombian patients. Methods: We included 120 healthy individual as controls and 120 melanoma cancer patients as cases . Patients in both groups were matched in terms of gender and age. The genotyping of rs731236 and rs2228570 polymorphisms was performed using PCR-RFLP. The SNPStats program was used to carry out the statistical analysis through a logistic regression model. Results: Under dominant model, we found that rs2228570 polymorphism was associated with melanoma cancer risk (C/C vs C/T-T/T, OR: 5.10, 95% CI: 2.85-9.14), whereas rs731236 polymorphism was associated with a protective effect against this cancer (T/T vs T/C, OR: 0.27, 95% CI: 0.14-0.53). Conclusion: Our results suggested that both polymorphisms were involved in the development of melanoma cancer, increasing or decreasing this risk.  UR - https://journal.waocp.org/article_89923.html L1 - https://journal.waocp.org/article_89923_278b45d76bbe6a163fed1dbb62cd254a.pdf ER -