TY - JOUR ID - 90080 TI - The Immunohistochemical Expression of SOX-10 in Urothelial Carcinoma and the Non Neoplastic Urothelium; and a Correlation with the Tumor Features JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Amer, Samar AU - Ibrahim, Heba AU - Elkordy, Miran AD - Department of Pathology, Kasr-Al-Ainy, Cairo University, Cairo, Egypt. AD - Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt. Y1 - 2022 PY - 2022 VL - 23 IS - 4 SP - 1425 EP - 1432 KW - Keywords: Urothelial carcinoma KW - Normal urothelium KW - SOX-10 DO - 10.31557/APJCP.2022.23.4.1425 N2 - Objective: Evaluation of SOX-10 expression in malignant urothelial cells, comparing it with the phenotypically non neoplastic urothelium, and correlating it with the various clinicopathological variables, with a focus on the invasive pattern. Methods: Eighty paraffin blocks of urothelial carcinoma were stained by H&E. Histopathological features were evaluated and then immunostained with SOX-10 to evaluate its expression. Results: The evaluation of SOX-10 expression in urothelial carcinoma, revealed a high grade of SOX-10 expression in the malignant urothelium (43\80 cases; 53.7%), while the adjacent the non neoplastic urothelium expressed high SOX-10 in (12\42 case; 28.6%). Correlation of SOX-10 score with the various variables revealed a statistically significant correlation with the gross shape (P value=0.002), the tumor grade ((P value=0.009), the muscle invasion by the tumor ((P value=0.004), the tumor T stage, (P-value <0.001), N stage (P value=0.003), associated Schistoma hematobium infestation (P-value =0.016), and the presence of vascular tumor emboli (P-value =0.009). It was statistically insignificant with the gender, the anatomical site, and the perineural tumor invasion. Correlating the mean of SOX-10 score with some tumor features revealed a statistically significant correlation with the muscle invasion by the tumor, Tumor grade, T stage, and  non neoplastic urothelium; P-value <0.001 each and N stage P value=0.006. Conclusion: SOX-10 is overexpressed in urothelial carcinoma and it was also detected in a significant part of the surrounding non neoplastic urothelium, which may contribute to understanding its role in multistep urothelial carcinogenesis as transcription or tumor-promoting factor, thus it could be used in future trials for specific targeted therapy.  UR - https://journal.waocp.org/article_90080.html L1 - https://journal.waocp.org/article_90080_280367447b9c106d2f16572eaff3df38.pdf ER -