TY - JOUR ID - 90087 TI - Evaluation of the Anti-Cancer/Anti-Mutagenic Efficiency of Lavandula officinalis Essential Oil JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Fahmy, Maha A AU - Farghaly, Ayman A AU - Hassan, Entesar E AU - Hassan, Emad M AU - Hassan, Zeinab M AU - Mahmoud, Khaled AU - Omara, Enayat A AD - Department of Genetics and Cytology, National Research Centre (NRC), Dokki, Giza, Egypt. AD - Department of Medicinal and Aromatic Plants Research, National Research Centre (NRC), Dokki, Giza, Egypt. AD - Department of Natural Compounds Chemistry, National Research Centre (NRC), Dokki, Giza, Egypt. AD - Department of Pharmacognosy, National Research Centre (NRC), Dokki, Giza, Egypt. AD - Department of Pathology, National Research Centre (NRC), Dokki, Giza, Egypt. Y1 - 2022 PY - 2022 VL - 23 IS - 4 SP - 1215 EP - 1222 KW - Lavandula officinalis KW - cancer cell lines KW - Cyclophosphamide KW - genotoxicity KW - histopathology DO - 10.31557/APJCP.2022.23.4.1215 N2 - Objective: Lavender oil is of a great economic importance. It has many biological and pharmacological activities. The present study aimed to identify the chemical constituents of the essential oil of Lavandula officinalis (LAEO) by using GC/MS analysis. Its genotoxicity, anti-genotoxicity and histopathological activities against the chemotherapeutic drug cyclophosphamide (CP) was investigated. The study also evaluated its anticancer activities against six human cancer cell lines: hepatocellular carcinoma (HepG2), Prostate (PC3), Lung carcinoma (A549), Skin cancer (A431), Colon cancer (HCT116) and Breast cancer (MCF7). Methods: The genotoxicity was determined using: micronucleus, chromosomal aberration, and comet assays. The histopathological study included liver. The examined groups were control negative, control plant, control positive (CP), and 3 combined groups received LAEO at different concentrations plus CP. Results: GC/MS analysis recorded 16 components. The principals were: linalool and linalyl acetate. The results indicated the safety of LAEO. It also attenuates genotoxicity and deleterious histopathological effects of CP in a dose-dependent manner. LAEO has a highly cytotoxic effect on HepG2 and A549 cell lines with 100% death at 100µg/ ml with IC50 67.8 and 12 µg/ ml, respectively. Its activity on other cell lines was weak. Conclusion: The essential oil of Lavandula officinalis has anticancer and anti-mutagenic effect. UR - https://journal.waocp.org/article_90087.html L1 - https://journal.waocp.org/article_90087_10a378a65a66f4858826c64f18f447dd.pdf ER -