TY - JOUR ID - 90166 TI - Gynecologic Malignancy-Associated Venous Thromboembolism and Predictive Tool at Thammasat University Hospital JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Jayasakoon, Karit AU - Punyashthira, Awassada AU - Somboon, Banthisa AU - Pattaraarchachai, Junya AU - Suwannarurk, Komsun AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand. AD - Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand. Y1 - 2022 PY - 2022 VL - 23 IS - 6 SP - 2113 EP - 2118 KW - Gynecologic malignancy KW - Venous thromboembolism KW - Prevalence KW - prediction KW - Caprini DO - 10.31557/APJCP.2022.23.6.2113 N2 - Objectives: Aims were to investigate the prevalence and risk factors of venous thromboembolism (VTE) in gynecologic malignancy cases. Value of screening tool (Caprini) for prediction of VTE was also assessed. Study design: A retrospective study of gynecologic malignancy subjects who underwent major gynecological operation via exploratory laparotomy at Thammasat University Hospital, Pathum Thani, Thailand from January 2015 to December 2020. Participants were categorized into VTE and non-VTE groups. Caprini score, associated laboratory and clinical factors of both groups were evaluated. Results: A total of 392 subjects were recruited into the study. Prevalence of VTE was 7.4 (29/392) percent. VTE was diagnosed in subjects with endometrial, ovarian and cervical cancer at percentage of 7.8 (15/192), 7.9 (11/138) and 5.7 (3/53), respectively. Demographic characters of both groups were comparable. VTE group had significant more Caprini score, platelets count and platelet lymphocyte ratio (PLR) than non-VTE group. Modified Caprini score (2 multiply Caprini score plus 1 multiply PLR) was generated for better VTE prediction. Sensitivity and specificity of Caprini (≥5.5) and modified Caprini scores (≥22.8) were 72.4 vs 39.4, and 79.3 vs 52.1 percent, respectively. Conclusion: Prevalence of VTE among gynecologic malignancy cases was 7.4 percent. The modified Caprini score was an alternative VTE predictive tool. Cut-off point of modified Caprini score at equal or more than 22.8 was proposed. UR - https://journal.waocp.org/article_90166.html L1 - https://journal.waocp.org/article_90166_67258f360d62dc03eda6d803f3b5bab7.pdf ER -