TY - JOUR ID - 90440 TI - A Primary Epithelioid Angiosarcoma Arising in a Bilharzial Urinary Bladder: A Reappraisal and Case Report JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Elatreisy, Adel AU - Hussein, Mahmoud Rezk Abdelwahed AU - Shalkamy, Osama AU - Aljubran, Abdulkareem Moeed AU - Aboelnasr, Mahmoud AU - Safar, Omar AU - Shah, Sayed AU - Elhadad, Ahmed Yousef Kandeel AU - Alqahtani, Saad AU - Ahmad, Nazal AU - Al-Ayafi, Mahdi AU - Bosily, Mohanad Jebril AU - Alhadi, Ahmed AD - Department of Urology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. AD - Department of Pathology, Assiut University Hospitals, Assiut, Egypt. AD - Department of Urology, Armed Forces Hospital Southern Region, Khamis Mushait, KSA. AD - Department of Pathology, Armed Forces Hospital Southern Region, Khamis Mushait, KSA. AD - Department of Radiology, Faculty of Medicine, Mansoura University, Egypt. AD - Department of Radiology, Armed Forces Hospital Southern Region, Khamis Mushait, KSA. Y1 - 2023 PY - 2023 VL - 24 IS - 1 SP - 87 EP - 92 KW - Epithelioid KW - angiosarcoma KW - bilharzial KW - urinary bladder DO - 10.31557/APJCP.2023.24.1.87 N2 - Background: Angiosarcoma (AS) of the urinary bladder is a very rare and aggressive malignancy with a dismal outcome. Case report: Here, we report a primary epithelioid angiosarcoma (EAS) of the urinary bladder in a forty-nine-year-old male patient who presented with severe hematuria. Cystoscopic examination revealed hemorrhagic ulcerated bladder mucosa but no definite mass lesions. Intractable hematuria raised the initial clinical impression of idiopathic hemorrhagic cystitis. Analysis of the cystoscopic biopsy revealed features of old bilharzial cystitis, markedly atypical epithelioid endothelial cells arranged as primitive anastomosing vascular structures and expressing vascular markers. The diagnosis of EAS was established. The patient developed intractable severe hematuria, and a radical cystoprostatectomy was performed. The patient was started on chemotherapy but suddenly developed widespread distant metastasis (liver, lung, suprarenal glands, and lymph nodes) and succumbed to death two months after the surgery. Conclusion: To the best of these authors’ knowledge, we presented the first report of primary EAS arising in a bilharzial bladder. The relevant studies were discussed. UR - https://journal.waocp.org/article_90440.html L1 - https://journal.waocp.org/article_90440_b23e6a66f39bb7c9c97dd8a3873f2935.pdf ER -