TY - JOUR ID - 90491 TI - Cytotoxic Activity of the Ethyl Acetate Extract of Iraqi Carica papaya Leaves in Breast and Lung Cancer Cell Lines JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Basim, Sura AU - Kasim, Ali A AD - Department of Pharmacognosy, College of Pharmacy, University of Baghdad, Baghdad, Iraq. AD - Department of Pharmacognosy and Medicinal Plants, Department of Pharmacognosy, College of Pharmacy, University of Baghdad, Iraq. Y1 - 2023 PY - 2023 VL - 24 IS - 2 SP - 581 EP - 586 KW - Anticancer KW - A549 KW - breast cancer KW - Carica papaya KW - MCF-7 DO - 10.31557/APJCP.2023.24.2.581 N2 - The aim of this study was to evaluate the cytotoxic effect of the ethyl acetate fraction of Iraqi Carica papaya (C. papaya) in breast and lung cancer cell lines, MCF-7 and A549, respectively. Methods: The ethyl acetate extract of Iraqi C. papaya leaves was prepared and tested for its phytochemical constitution.  The  3-(4,5-dimethylthiazoline-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed in breast (MCF-7) and lung (A549) cells lines that were treated with different concentrations of ethyl acetate extract (3.125,6.25,12.5, 25, 50, and 100μg/ml). After 72 hrs of treatment, cell viability was evaluated. Results: The ethyl acetate extract of C. papaya showed considerable cytotoxic activity in the MCF-7 and A549 cell lines. The activity was dose-dependent; The half-maximum inhibitory concentration (IC50) values were 22.74μg/ml and 8.674 μg/ml in the MCF-7 and A549 cell lines, respectively. Conclusion : The  ethyl acetate fraction of Iraqi C. papaya leaves has potential anticancer activity in lung and breast cancer. UR - https://journal.waocp.org/article_90491.html L1 - https://journal.waocp.org/article_90491_069ec139d0cf2453463bed3e9ce4929f.pdf ER -