2024-03-28T13:57:09Z
https://journal.waocp.org/?_action=export&rf=summon&issue=8484
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Precision in Oncology; a Future Prospect
Reza
Shirkoohi
It can be considered that cancer is a disease the prevalence of which has been increased with the world modernization. Many other diseases such as huge infectious pandemics and natural or unnatural disasters have already shorten the mean age of human beings and there has been little chance for neoplastic malignancies to come on sight among the population. Malignancies have various profiling based on the characteristics of the cell origin and tumor type. There are different alterations in genetic, epigenetic, protein function, microenvironment and other systematic interactions during disease progression. In some cases, using different types of drugs which are more compatible with the morphology of the majority of cells in a tumor can cause the other cells with different genetic and epigenetic profiling to proliferate which leads to treatment failure and progression of disease to more advance stages such as systemic metastasis. Personalizing therapeutic decision for advanced patients has been performed in recent years. There are different reports of improvement of quality of life or survival enhancement and even complete remission in some advanced cases as a result of managing tumor molecular information and cell signaling analysis. Personalized medicine is still in the beginning of its way and needs more investigation and infrastructural research. Finding new biomarkers and targets in cell signaling which is involved in different aspects of disease will be helpful to increase the percentage of sensitivity in decision making.
cancer
Molecular Genetics
Personalized Medicine
Metastasis
Biomarker
2018
07
01
1739
1740
https://journal.waocp.org/article_65357_cf96abfcc8bdb01fdfe2a27f2391e596.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Detection of HBV Genotype C in Hepatocellular Carcinoma Patients from North East India: a Brief Report
Manash P
Sarma
Minakshi
Bhattacharjee
Premashis
Kar
Subhash
Medhi
Background and Objectives: Newer genotypes of HBV have been reported from India. This study was aimed todetermine the circulating genotypes of HBV in hepatocellular carcinoma patients from three different geographicallocations of India. Methods: 141 HBV related HCC cases were included from three different hospitals across the country.Genotyping of HBV was performed by PCR using type specific primers specially designed in 70 cases. Samples ofinterest were confirmed by direct sequencing of the precore/core region of HBV genome. Results: Genotypes couldbe detected in 40 (57.14%) out of the 70 HBV DNA positive HCC cases by type specific primers. HBV genotype Dwas documented in 20 (50%), genotype A in 10 (25.0%) and genotype C in 10 (25.0%) of these HCC cases. GenotypeC of HBV was detected only in the samples from North East India. No significant difference was observed for thebiochemical profile. Conclusion: Although Genotype D is the major HBV genotype in India followed by A, detectionof HBV genotypes C in HCC patients indicates a changing epidemiology of the virus in India that may require regionbased management of the virus.
HBV
HCC
genotype C
North East India
South India and North India
2018
07
01
1741
1746
https://journal.waocp.org/article_64835_4f83e3a15752fe6184383286eae832bf.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Diagnostic Accuracy of Different Machine Learning Algorithms for Breast Cancer Risk Calculation: a Meta-Analysis
Ricvan Dana
Nindrea
Teguh
Aryandono
Lutfan
Lazuardi
Iwan
Dwiprahasto
Objective: The aim of this study was to determine the diagnostic accuracy of different machine learning algorithmsfor breast cancer risk calculation. Methods: A meta-analysis was conducted of published research articles on diagnostictest accuracy of different machine learning algorithms for breast cancer risk calculation published between January 2000and May 2018 in the online article databases of PubMed, ProQuest and EBSCO. Paired forest plots were employed forthe analysis. Numerical values for sensitivity and specificity were obtained from false negative (FN), false positive (FP),true negative (TN) and true positive (TP) rates, presented alongside graphical representations with boxes marking thevalues and horizontal lines showing the confidence intervals (CIs). Summary receiver operating characteristic (SROC)curves were applied to assess the performance of diagnostic tests. Data were processed using Review Manager 5.3(RevMan 5.3). Results: A total of 1,879 articles were reviewed, of which 11 were selected for systematic review andmeta-analysis. Fve algorithms for machine learning able to predict breast cancer risk were identified: Super VectorMachine (SVM); Artificial Neural Networks (ANN); Decision Tree (DT); Naive Bayes (NB); and K-Nearest Neighbor(KNN). With the SVM, the Area Under Curve (AUC) from the SROC was > 90%, therefore classified into the excellentcategory. Conclusion: The meta-analysis confirmed that the SVM algorithm is able to calculate breast cancer risk withbetter accuracy value than other machine learning algorithms.
Breast cancer risk
calculation
Machine Learning
algorithms
2018
07
01
1747
1752
https://journal.waocp.org/article_65369_3bb0837a34fec5a8fc794abdcbba7274.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
The Clinical Significance of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography in Patients with Occupational Cholangiocarcinoma
Masahiko
Kinoshita
Shigekazu
Takemura
Shogo
Tanaka
Hiroji
Shinkawa
Genya
Hamano
Tokuji
Ito
Masaki
Koda
Takanori
Aota
Yasuni
Nakanuma
Yasunori
Sato
Shoji
Nakamori
Akira
Arimoto
Takatsugu
Yamamoto
Hideyoshi
Toyokawa
Shoji
Kubo
Objective: The present study aimed to identify the clinical significance of fluorine-18 fluorodeoxyglucose positronemission tomography (FDG-PET) imaging in patients with occupational cholangiocarcinoma. Methods: This studyincluded 10 men with occupational cholangiocarcinoma who were former or current workers at a printing company inOsaka, Japan. Of the 10 patients, 2 had 2 main tumors and 1 had 3 main tumors. Twelve FDG-PET imaging findingsin the 10 patients could be analyzed. We evaluated the relationships between FDG-PET imaging parameters andclinicopathological findings of occupational cholangiocarcinoma. Results: Abnormal FDG uptake was observed in 8 ofthe 14 main tumors, with maximum standardized uptake values ranging from 2.9 to 11.0, and the sensitivity was 57.1%.Four patients had lymph node metastases, and abnormal marrow uptake was detected in all these patients. Althoughprecancerous lesions, such as biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bileduct (IPNB) without any invasion, were not detected, abnormal FDG uptake was demonstrated in 2 of 4 patients withIPNB having an associated invasive carcinoma.Conclusions: Although FDG-PET may be useful for assessing tumorprogression factors, such as lymph node metastasis, it cannot accurately detect precancerous lesions, such as BilINand IPNB without invasive carcinoma.
Occupational cholangiocarcinoma
Lymph node metastasis
Biliary intraepithelial neoplasia
Intraductal papillary neoplasm of the bile duct
Fluorine-18 fluorodeoxyglucose positron emission tomography
2018
07
01
1753
1759
https://journal.waocp.org/article_65365_b37127285f811454d22d4eb57959fc26.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
A Case-control Study Supporting the Use of Liquid Biopsy in the Targeted Therapy for Lung Cancer
Li-Jun
Dai
Chun
Wang
Zhen-Yu
Ding
Backgrounds: Targeted therapy for lung cancer depends on the genetic testing. Liquid biopsy provides a valuablesource for the genetic testing. However, direct evidence was lacking for whether liquid biopsy could guide the targetedtherapy. Methods: In this retrospective study, the admitted patients from Jan 2015 to Feb 2016 were screened througha pre-established database. Patients with metastatic, pathologically-confirmed, and treatment naïve non-small celllung cancer who were prescribed with epithelial growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) fromthe guidance of liquid biopsy were enrolled (Liquid group). The mutation status in tumors was not mandatory. Duringthe same period, patients medicated with TKI based on tumor samples were included in the Control group. They wereenrolled in an age-, gender-, performance-, smoking-, and histology-matched manner. Results: We screened 536 patientsand enrolled 26 patients in the Liquid group. Another 26 patients were enrolled in a 1:1 ratio in the Control group.In the Liquid group, a high consistence (84.6%) in EGFR mutation status between liquid and tumor was observed.The best response was partial response in 19 patients (73.1 %), and followed by stable disease in 6 patients (23.1 %).The median progression-free survival was 10.0 months (95%CI: 4.2-15.8 months). In the Control group, a similar diseasecontrol rate (88.4%, P=0.603) and comparable PFS (8.6 months, 95% CI: 7.6-10.4 months, P=0.714, HR=0.657, 95%CI: 0.309-1.396) was found. In the Liquid group, 3 of 4 patients with discordant results between tumor and liquid biopsyshowed treatment responses favoring the liquid biopsy. Conclusion: This study provided direct evidence supportingthe liquid biopsy for guiding the targeted therapy for lung cancer.
epithelial growth factor receptor (EGFR)
iquid biopsy-lung cancer (NSCLC)
progression-free survival (PFS)
2018
07
01
1761
1766
https://journal.waocp.org/article_64946_e079d93718673de74d6b0b473d3cec42.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Relationships between Reproductive Risk Factors for Breast Cancer and Tumor Molecular Subtypes
Nahid
Nafissi
Maryam
Faraji
Mostafa
Hosseini
Leyla
Shojaee
Fatane
Ziaee
Mohamad Esmaiel
Akbari
Seyed Hamzeh
Mousavie
Background: Due to wide clinical differences in the various pathological types of breast cancer and also closeassociations between disease prognosis and molecular subtypes, relationships of the latter with traditional risk factorshave been suggested. Hence, the present study aimed to assess any associations. Methods: This bi-center cross-sectionalstudy was performed on 800 consecutive women with known breast cancer referred to two Comprehensive Cancer Centersin Tehran between 2006 and 2016. Baseline information related to reproductive risk profiles as well as pathologicaltumor diagnosis and molecular subtypes determined using immunohistochemical analysis by immune-staining forER, PR, and HER2 molecules were collected by reviewing hospital records. Results: Of 800 samples included forimmunohistochemical analysis, 314 (39.3%) were diagnosed as of Luminal A subtype, 107 (13.4%) as Luminal Bsubtype, 153 (19.1%) as HER-2 over-expressing, and 226 (28.3%) as triple negative. Among all reproductive riskfactors initially assessed, young age was associated with HER-2 over-expression, greater tumor size and a history ofabortion with the luminal B subtype, lower age at pregnancy with the luminal A subtype, and lower gravidity anda shorter duration of breastfeeding with the triple negative subtype. Conclusion: Each molecular subtype of breastcancer in our population may be associated with specific reproductive risk factors.
Reproductive
breast cancer
Tumor marker
HER2
tumor molecular subtypes
2018
07
01
1767
1770
https://journal.waocp.org/article_63508_2969dfb9f29b33f9bdbb5b54abcc65b3.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Knowledge and Perception Towards Cervical Cancer among Female Debre Berhan University Students
Kalayu Birhane
Mruts
Tesfay Birhane
Gebremariam
Background: Cervical cancer is a global public health problem with around five hundred thirty thousand new casesand two hundred sixty five thousand deaths annually in 2015. Risky behaviors, lack of knowledge and preventativemeasures in young women, increase the risks of cervical cancer later in life. Up to date, there is scarcity of study onlevel of knowledge and perception towards cervical cancer among young women in Ethiopia. So, this study was aimed todetermine the level of knowledge and perception toward cervical cancer among female regular undergraduate DebreBerhan University students. Methods: A facility based cross-sectional study was conducted using self-administeredquestionnaire among female regular DBU students from May to June, 2015. Two stage cluster sampling technique wasused for the study. Data was entered and cleaned in Epi info and imported to SPSS for analysis. Binary logistic regressionwas carried out to determine factors of good knowledge on cervical cancer. P-value less than 0.05 was considered forstatistical significance. Results: Eighty-four (14.5%) of the study participants were sexually active. Of the participants,232(40.5%) had heard of cervical cancer but only 195 (35.6%) had good knowledge towards cervical cancer and ofthe study participants, only 185 (33.2%) perceived as they are susceptible for cervical cancer. Using radio and TV assource of information [AOR= 1.918 (95% CI: 1.223, 3.010)], having information about sexually transmitted infections(STI) [AOR =3.030 (95% CI: 1.665, 5.514)] were significantly and independently associated with good knowledge oncervical cancer. Conclusions: The level of knowledge towards cervical cancer and perception of acquiring the diseasewas poor. Health education interventions are needed to improve the awareness and health seeking behavior in youthwomen thereby preventing cervical cancer related morbidity and mortality.
Cervical cancer
Knowledge
Perception
Debre Berhan
Ethiopia
2018
07
01
1771
1777
https://journal.waocp.org/article_63651_3bd08f2e0a64576c3924acd81156fcc3.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Immunohistochemical Evaluation of GLUT-3 and GLUT-4 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma
Sthefane Gomes
Feitosa
Khalil Fernandes
Viana
Ealber Carvalho Macedo
Luna
Fábio Wildson Gurgel
Costa
Roberta Barroso
Cavalcante
Filipe Nobre
Chaves
Hellíada Vasconcelos
Chaves
Karuza Maria Alves
Pereira
Objectives: To evaluate immunohistochemically the expression of GLUT-3 and GLUT-4 in oral epithelial dysplasia(OED) and the oral squamous cell carcinoma (OSCC) and assess possible involvement in the malignant transformation oforal lesions. Methods: Tissue samples of 15 cases of OSCC and 15 of OED were subjected to immunohistochemistrywith anti-GLUT-3 and anti-GLUT-4 antibodies. Five fields of each case were analyzed, to provide percentages ofpositive cells at 400X magnification. Result: GLUT-3 and GLUT-4 were positive in 100% of the analyzed samples,the percentage immunolabeling for GLUT-3 ranging from 19% to 73% in the OED group and 10% to 89% in the OSCCgroup. Positive immunolabeling for GLUT-4 ranged from 15.2% to 79.9% in the OSCC group and 27.1% to 92.6% inthe OED group. Statistical analysis with the Mann-Whitney test revealed that there was a higher expression of GLUT-4 inthe OED group than in the OSCC group (p=0.04) without any significant difference in the GLUT-3 expression (p=0.852).Conclusion: GLUT-4 expression may indicate some role in oncogenic mechanisms which can determine a malignantphenotype. Thus, it is suggested that further studies on the role of GLUT-3 in oral carcinogenesis be conducted.
oral epithelial dysplasia
oral squamous cell carcinoma
GLUT proteins
immunohistochemistry
2018
07
01
1779
1783
https://journal.waocp.org/article_63642_666c3143d6fbdc93fc224a166fd34f64.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Selenium Influences Trace Elements Homeostasis, Cancer Biomarkers in Squamous Cell Carcinoma Patients Administered with Cancerocidal Radiotherapy
Sonaa
Elango
Shila
Samuel
Zenith
Khashim
Usha
Subbiah
In the perspective of selenium as an antioxidant and anti-carcinogen, so far no strong intervention trials withselenium over radiation-treated oral squamous cell carcinoma cases have been conducted, to examine the response ofthe disease and the subsequent biochemical alterations. In the present study, untreated oral cancer cases (Gp II) werecompared with radiation-treated groups with and without selenium (Gp IIa, IIb), forward to find the trace elementsand cancer biomarkers status, at a follow-up of 6 months. Severe alteration in the trace elements levels of Se, Cu,Fe, Zn, Na, K, Ca, Cl, were noticed in Gp II. Though Gp IIa showed slight improvement, administration of selenium(Gp IIb) improved the level of all these elements to a greater extent (p<0.001). GpII and IIa showed increased level ofbio markers 5’-nucleotidase, PschE, LAP, γ-GTP, LDH, SGOT, SGPT, ACP, ALP, CPK, TNF, CEA, AFP, Scc-Ag.The greater extent of restitution to near normalcy was observed in patients given selenium (Gp IIb) (p<0.001). Owing tothe fact that selenium scavengers oxidants and hence decelerate carcinogenesis by eliminating tumors, so the tumorreleased constituents into the systemic circulation declined significantly. Therefore, the outcome of the study suggestsselenium as a valuable therapeutic measure as adjuvant for oral cancer patients undergoing cancerocidal radiotherapy.
trace elements
cancer biomarkers
selenium
oral cancer
oxidative stress
2018
07
01
1785
1792
https://journal.waocp.org/article_64830_dd1b745651e1079aca0e2d9847f11da4.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Molecular Grading of Oral Squamous Cell Carcinomas Infected with EBV
Theresia Indah
Budhy
Background: Squamous Cell Carcinoma (SCC) is a type of cancer that is often found in oral cavity and areas ofthe head and neck. Viruses are major etiological factors through production of factors that can disturb proliferationand apoptosis regulators such as p53i, c-myc and bcl-2. This study aimed to determine the molecular grading of oralsquamous cell carcinoma (OSCCs) infected with the Epstein-Barr Virus (EBV). Methods: Twenty-seven OSCC patientsunderwent biopsy to detect EBV infection through in situ hybridization for RNA EBV (EBER) and immunohistochemicalanalysis of latent membrane protein-1 (LMP-1) and EBV nuclear antigen-1 (EBNA-1). To assess molecular grades, cellproliferation and apoptosis regulator expression i.e. inactive p53 (p53i), c-myc and bcl-2, were immunohistochemicallyanalysed. Results: The cases were divided into two groups; infected and non-infected by EBV. Regression analysisshowed that only EBNA-1 expression could affect p53i expression. Based on regression equations molecular grading ofOSCCs infected by EBV was divided into three: Grade I (low), EBNA-1 expression was 7.60, and p53i expressionwas 9.74-17.5; Grade II (medium), EBNA-1 expression was 7.61-19.7, and p53i 17.5-30.1; Grade III (high), EBNA-1expression was 19.71, and p53i ≥ 30.1. Conclusion: In OSCC infected with EBV, only EBNA-1 expression caninfluence p53i expression.
Bcl-2
EBER
EBNA-1
OSCC
p53i
2018
07
01
1793
1796
https://journal.waocp.org/article_65158_93453e3ea136fbfcdad017657ea7f2ff.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Elective Neck Dissection for Management of Early-stage Oral Tongue Cancer
Zeiad S
Gad
Osama A
El-Malt
Mostafa A T
El-Sakkary
Mohamed M
Abdal Aziz
Background: The occult neck metastasis rate is very high with tongue cancers. The aim of this study was to assessthe current role of elective neck dissection (END) in management of early-stage oral tongue cancer with a focus onlymph node metastasis. In addition, effects of END on regional or systemic disease recurrence and survival wereinvestigated. Methods: This retrospective study included patients with stage I and II tongue cancer recruited fromour National Cancer Institute (NCI) over a time period of six years (2007-2013). The collected data were analyzed fordisease free survival (DFS) and recurrence rate. Results: A total of 144 patients presented to our NCI with oral tonguecancer but only 88 were staged clinically and radiologically as early stage (stage I, stage II). Some 53% were smokers.Most lesions were dealt with by surgery, either by wide local excision (22%) or hemiglossectomy (78%). Treatment ofneck lesions was either by neck dissection (85.2%) or “wait and see” (14.8%). The rates for local and nodal recurrencewere 7.9% and 20.4%, respectively. Analysis of associations between DFS and different factors revealed significancefor adoption of adjuvant therapy and the dissected lymph node status. Conclusion: Controversy still exists regardingneck management.
Elective neck dissection
Occult metastasis
Squamous Cell Carcinoma
2018
07
01
1797
1803
https://journal.waocp.org/article_65187_cfc0d230a5f30253dc05f81b60483dfe.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Immunohistochemically Detection of Angiogenesis in Oral Pre-Cancerous Lesions Compared with Oral Invasive Carcinomas
Neda
Kargahi
Nakisa
Torabinia
Seyed Mohammad
Razavi
Dana
Tahririan
Hasan
Kamani
Masoud
Nazari
Background: Angiogenic activity is an important event in oral carcinogenesis. During transition of normaloral mucosa to different grades of dysplasia and to invasive carcinoma, significant increase of vascularity occurs.Angiogenesis can be determined by immunohistochemical assessment of several endothelial cell markers likeEndogelin (CD 105), expressed in activated endothelial cells and associated with neovasculature, and the vascularendothelial growth factor (VEGF). This study was conducted to evaluate angiogenic activity in oral precancerous lesionscompared with oral invasive carcinomas by immunohistochemical staining of VEGF and CD 105 proteins. Methods:In the present cross-sectional study, 20 normal, 20 pre-cancerous mucosa and 20 oral invasive carcinoma sampleswere immunohistochemically stained. Positive cells were counted in each section and micro vessel density (MVD)was determined. The data were statistically analyzed by Mann-Whitney and Kruskal-Wallis tests, with a P-value ≤0.05considered significant. Results: The mean expression value for VEGF was 24.6 in oral invasive carcinoma, 16.4 inprecancerous mucosa and 15.5 in normal mucosa, with no significant differences between the latter two. Endoglinwas negative in all normal mucosa samples, but had scores of 7.58 for precancerous mucosa and 19.4 in oral invasivecarcinoma specimens. MVD was significantly higher in SCC than in dysplastic mucosa. Conclusion: Oral invasivecarcinoma has more angiogenic activity in comparison with pre-cancerous lesions and normal mucosa. Given the highexpression of CD105 positive vessels in malignant lesions, we can argue that determination of mean vessel density (MVD)by application of the CD105 marker could be a useful parameter to differentiate cancerous from pre-cancerous lesions.
angiogenic activity
immunohistochemistry
precancerous lesions
Squamous Cell Carcinoma
2018
07
01
1805
1808
https://journal.waocp.org/article_63648_88e0263caa0ec89a125720f638207d12.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Changes in Health- Related Quality of Life and Psychosocial Well-being of Breast Cancer Survivors: Findings from a Group- Based Intervention Program in Malaysia
Nisha Angela
Dominic
Valliammai Jayanthi
Thirunavuk Arasoo
Nevein Philip
Botross
Amgad
Riad
Cindy
Biding
Amutha
Ramadas
Background: There is a lack of evidence on the effectiveness of multifaceted group-based interventions toimprove psychological well-being and health-related quality of life (HRQOL) of breast cancer (BCa) survivors inMalaysia. This study is aimed at assessing the effectiveness of such intervention program among the BCa survivors.Materials and Methods: This was a group-based intervention program with pre- and post-test design, carried outamong BCa survivors (n=37) who were members of Breast Cancer Support Group Centre, Johor Bahru. A validatedself-administered questionnaire was used to assess the impact of the program on psychosocial well-being and HRQOL ofthe participants. Results: The mean age of BCa survivors was 58.1 years (SD=9.7), with mean age at diagnosis of49.9 years (SD=9.6). Majority of them were of Chinese ethnicity, married and had secondary level education, butwere unemployed. More than 86% of them were diagnosed to have early BCa diagnosis and have since completedthe treatment. There were significant decreases in median depression (p=0.001), anxiety (p<0.001) and stress (p<0.001)scores at post-intervention. More than 85% of the participants rated themselves to have a good or very good QOLat post-intervention, as opposed to 75.9% at pre-intervention. Significant improvements in several HR-QOL domainscores were seen, with psychological score improving the most (p<0.001), followed by social relationship (p=0.002)and physical health (p=0.004). Conclusions: Group-based multifaceted intervention can be a viable solution to improvepsychosocial well-being of BCa survivors.
Breast cancer survivors
psychosocial
Health-related quality of life
multi-faceted intervention
2018
07
01
1809
1815
https://journal.waocp.org/article_65372_7f8ae4dd656a66f5e131fb0933261a74.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Estimating Willingness to Pay for an Improved Service Delivery to Patients Referring Namazi Hospital Chemical Therapy Ward in Iran Using Contingent Valuation
Zahra
Kavosi
Abdosaleh
Jafari
Vida
Keshtkaran
Elahe
Pourahmadi
Objective: The aim of this study was to estimate patients’ willingness to pay (WTP) for improving the quality ofnon-medical aspect in Namazi hospital patients chemotherapy an assessment using the contingent valuation method(CVM). Patients and Methods: This was an applied, cross-sectional and analytical-descriptive study carried out inIran, Shiraz in 2013. A sample of 185 patients was determined using random sampling. Multiple choice questions andfollow-up open-ended questions were employed to elicit patients’ WTP. The question asked patients would have topay for this improving their own pocket. linear regression were used to Econometrically estimate the maximum WTPusing STATA 11 software. Results: The results of this study indicated that 31% were male and 69% were female andthe adjusted mean WTP was PPPUS$15 for pat maximum amount of willing to pay was for to get the same qualityservice in own city respondents (PPPUS$16) and minimum amount of willing to pay was to get advice of experiencednurse(PPPUS$10) Patients were willing to pay more if their satisfaction with two attributes of care were increased.The cancer type and income taking care of you are significant factors influencing a patient’s WTP. Conclusions: In theworst socio-economic conditions of the people were willing to pay to improve the reducing wait times in receiving adrug and get the same quality service in own city respondents. In Future efforts Health policymakers should considerthe ability to pay when making their decision.
quality improvement
Willingness to pay
Chemotherapy
2018
07
01
1817
1823
https://journal.waocp.org/article_64789_d25447a26e063aec6ccf1a6cd678ea73.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
The Frequency of SF3B1 Mutations in Thai Patients with Myelodysplastic Syndrome
Punchita
Rujirachaivej
Teerapong
Siriboonpiputtana
Budsaba
Rerkamnuaychoke
Suthada
Magmuang
Takol
Chareonsirisuthigul
Paisarn
Boonsakan
Sawang
Petvises
Tanasan
Sirirat
Pimjai
Niparuck
Suporn
Chuncharunee
Genetic mutations in genes encoding critical component of RNA splicing machinery including SF3B1 are frequentlyidentified and recognized as the pathogenesis in the development of myelodysplatic syndrome (MDS). In this study,PCR sequencings specific for SF3B1 exon 13, 14, 15, and 16 were performed to analyse genomic DNA isolated frombone marrow samples of 72 newly diagnosed MDS patients. We found that 10 of 72 (14%) patients harbor SF3B1missense mutations including E622D (1/72), R625C/G (2/72), H662Q (1/72), K666T (1/72), K700E (4/72) and G740E(1/72), respectively. Mutations were predominantly located on exon 14 and 15 of SF3B1 coding sequence. Interestingly,patients with SF3B1 mutations exhibited higher platelet counts (195×109/L VS. 140×109/L, p-value = 0.025) as well aslower hemoglobin levels (81 g/L VS. 92 g/L, p-value = 0.009) and associated with ring sideroblast phenotype (p-value< 0.001) when compared with patients without the SF3B1 mutation. In summary, we reported the frequency of SF3B1mutations in Thai patients with different subtypes of MDS. SF3B1 mutations were predominantly occurred in MDS-RSand considered as favourable prognosis value. This study further highlighted the clinical important of SF3B1 mutationsanalysis for the classification of MDS.
Myelodysplastic syndrome
RNA splicing machinery
SF3B1 mutation
2018
07
01
1825
1831
https://journal.waocp.org/article_64833_6610760fa1ba82f5dc546030c3b01326.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Awareness of Risk Factors, Symptoms and Time to Seek Medical Help of Ovarian Cancer amongst Omani Women Attending Teaching Hospital in Muscat Governorate, Oman
Mohammed
Al-Azri
Maytha
Al-Saidi
Eman
AL-Mutair
Sathiya Murthi
Panchatcharam
Background: Ovarian cancer has been regarded as most deadly gynaecological cancer in the world. In Oman,ovarian cancer is the third most prevalent gynaecological cancer affecting Omani women. The awareness of risk factors,symptoms and seeking early medical care play a role in the improvement of survival rates. The aim of this study is toexplore knowledge, risk factors, symptoms and the time taken to seek early medical help for ovarian cancer amongOmani women attended Sultan Qaboos University Hospital. Methods: The ovarian Cancer Awareness and Measure(CAM) questionnaire (translated into Arabic) was used to collect data. Results: A total of 499 women participated.The most recognised risk factors were having ovarian cysts (71.3%), smoking (67.5%) and having close relative withovarian cancer (63.5%); the least recognised were having in vitro fertilization (25.5%), having children (26.3%) andusing talcum powder in the genital area (31.5%). The most recognised symptoms were persistent pain in the pelvis(67.7%), persistent pain in the abdomen (60.3%) and extreme fatigue (56.5%); the least recognised were feeling fullpersistently (22.8%), passing more urine than usual (31.1%) and changes in bowel habits (32.1%). Multinomial logisticregression showed recognition of risk factors and symptoms were associated with a higher level of education, a higherincome, increased age, higher number of pregnancies, a longer duration of marriage and having a family history ofovarian cancer. Most of the barriers to seeking medical help were for several emotional, practical and healthcare servicereasons. Conclusion: The overall level of recognition of risk factors and symptoms of ovarian cancer among Omaniwomen were low with several emotional, practical and service barriers preventing them from seeking early medicalhelp. More measures to raise national cancer awareness levels are needed, and support for women to overcome thesebarriers to minimized delays in the presentation.
Ovarian Cancer
Symptoms
awareness
Barriers
Oman
2018
07
01
1833
1843
https://journal.waocp.org/article_64827_407580a1185560e791e6fa06cd811eb3.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Estimating the Burden of Cancer and Treatment Cost Related to Alcohol Consumption in Indonesia: a Descriptive Study
Susi Ari
Kristina
Dwi
Endarti
Chairun
Wiedyaningsih
Agustina Nila
Yuliawati
Suzan
Astyamalia
Background: Alcohol consumption has become one of the most common cancer risk factors after smoking.Nowadays, estimation of the burden of disease attributable to alcohol has become standard in documenting the impactof health problems, but it has been rarely performed in Indonesia. The aim of this study was to estimate treatmentcost of cancer related to alcohol consumption among the Indonesian population. Methods: This research design wasdescriptive with a prevalence-based approach using secondary data. Proportions of cancers were calculated using analcohol-attributable fractions (AAF) formula. Treatment costs for eight types of cancer were assessed according toaverage treatment cost per patient from the national universal health coverage database for 2016. Result: The topthree AAFs for males were cancers of the pharynx, esophagus and larynx (17.5%, 15.3% and 7.98%, respectively),while in females they were cancers of the esophagus, pharynx and stomach (2.15%; 1.39%; 0.83%). Among the eighttypes of cancer studied, the highest incidence in males was noted for liver cancer (132 cases) while colorectal cancerwas the most common among females (31 cases). Treatment cost for cancers related to alcohol consumption werehighest for colorectak cancer followed by laryngeal and liver cancer (116,083, 98,325 and 93,253 USD, respectively.Conclusion: The expenditure for treatment of cancers related to alcohol consumption accounts for about 1.71% oftotal cancer treatment cost. Since cancers related to alcohol consumption can be considered having an economicimpact in Indonesia, it becomes important for the government to control alcohol consumption so that related healthcareexpenditure can be minimized.
alcohol
cancer
treatment cost
Indonesia
2018
07
01
1845
1849
https://journal.waocp.org/article_65184_2ac3ce5b15b197437b14a60f3276dadf.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Clinical and Socio- Demographic Risk Factors for Acquisition of Helicobacter pylori Infection in Nigeria
Stella
Smith
Tolu
Jolaiya
Muinah
Fowora
Pia
Palamides
Favour
Ngoka
Moses
Bamidele
Olufunmilayo
Lesi
Charles
Onyekwere
Rose
Ugiagbe
Ifeanyi
Agbo
Dennis
Ndububa
Olusegun
Adekanle
Abimbola
Adedeji
Isaac
Adeleye
Ute
Harrison
Background: The aim of the study was to assess clinical and socio-demographic characteristics as well as priordrug usage as risk factors for Helicobacter pylori (H. pylori) infection in Nigeria. Methods: A total of 347 respondentswere surveyed by assessing their clinical and socio-demographic characteristics in comparison with the non-invasivegold standard for H. pylori diagnosis, the urea breath test (UBT). Chi-square test and odds ratio analyses wereconducted in order to assess if variables such as socio-demographic factors, drug intake, and history of ulcer/gastritis/gastric cancer within the family significantly predicted test results. Results: A total of 130 (37.5%) respondents werepositive for H. pylori by the UBT. Living with more than three people in an apartment and a history of ulcer/gastritiswithin the family were significantly associated with H. pylori (p ≤0.05), as well as current antibiotic intake (p ≤0.05).Nationality, stay outside Nigeria, level of education, main occupation, smoking and drinking habits, sources of drinkingwater, number of children and history of gastric cancer had no significant association with H. pylori infection (p ≥ 0.05).Conclusion: The results of the questionnaire revealed that most socio-demographic characteristics of the respondentshad no significant association with H. pylori. Overcrowding, having siblings/parents with history of ulcer/gastritis aswell as prior antibiotic usage had a significant association.
Helicobacter pylori
risk
factors
acquisition
Nigeria
2018
07
01
1851
1857
https://journal.waocp.org/article_65190_14f14c752899557d15ebbd095ff2f009.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Psychometric Evaluation of the Brunei-Malay SF-36 version 2 Health Survey
Mohammed M
Alhaji
Nur Hanisah
Johan
Shahrima
Sharbini
Mas RW
Abdul Hamid
Muhammad A
M Khalil
Jackson
Tan
Lin
Naing
Nik A
A Tuah
Objectives: To culturally adapt the Short Form Health-36 version 2 (SF-36v2) into the Brunei-Malay context anddetermine its reliability and validity for measuring health-related quality of life (HRQOL) in healthy individuals andpatients with chronic kidney disease in Brunei Darussalam. Methods: An iterative multistep strategy involving setting upa bilingual expert panel, pretesting, text revision and back translation was used to prepare the Brunei-Malay SF-36v2 asan adaptation from the Malaysian-Malay SF-36v2. The Brunei-Malay SF-36v2 was then self-administered to a sample ofhealthy individuals (n=95) and predialysis chronic kidney disease outpatients (n=95) resident in Brunei. The mean(SD) age of the participants was 46.6 (17.8) years. Results: Data completion rate was 100% with minimal floor effects(≤0.21) in all the 8 domains and >15% ceiling effects in 3 of the 8 domain scales. Cronbach’s alpha was >0.70 for allthe 8 domain scales. Scaling success was 100% for convergent validity, with 100% item discriminant validity for alldomain scales except Social Functioning (94%), Mental Health (85%) and General Health (85%). Principal componentanalysis of the two-factor dimension explained 68% overall variance and accounted for 81% reliable variance, but theexact SF-36 two-factor summary constructs in the standard algorithm were not replicated in the Bruneian population.Conclusions: The Brunei-Malay SF-36v2 is a valid and reliable instrument for measuring HRQOL in healthy individualsand patients with chronic kidney disease in Brunei. The summary scales should, however, be interpreted with caution.Further studies should be carried out to assess additional psychometric properties of the Brunei-Malay SF-36v2.
HRQOL
SF-36
Validity
Reliability
Asia
2018
07
01
1859
1865
https://journal.waocp.org/article_64831_4ce3f31bdea247ad23d57b3c15c1268b.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Identifying the Social Determinants of Breast Health Behavior: a Qualitative Content Analysis
Salah Eddin
Karimi
Hassan
Rafiey
Homaira
Sajjadi
Farhad
Nosrati Nejad
Background: Prevention, early diagnosis and reduction of mortality caused by breast cancer are the priorities ofthe world health systems. The aim of this study was to identify the social factors that affect the women’s breast healthbehavior based on the social determinants model of the World Health Organization (WHO). Materials and Method:This qualitative study was conducted and analyzed using content analysis approach. The data were collected from32 participants by semi-structured interviews and focused group discussion. The participants comprised of breastsurgeons, radiologists, health care providers and women over 35 years of age in Tehran who were selected throughpurposeful sampling. The interviews continued until data saturation was reached. Results: Based on the experiences ofthe participants, three themes were obtained from the data that shaped the women’s breast health behavior, including1) the context of health policy, 2) socioeconomic status, and 3) cultural, psychological, and behavioral factors.Conclusion: A better understanding of social determinants related to breast health behavior can be effective in designingand applying of appropriate theories and models of education and intervention, so that, by early diagnosis of breastcancer and timely treatment of patients, the disease complications and mortality would be reduced.
Social Determinants of Health
breast cancer
Health behavior
Breast health behavior
Qualitative Content Analysis
2018
07
01
1867
1877
https://journal.waocp.org/article_64791_e746afccb86e61244e49773ff4fcd5a9.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
p53 Overexpression in Oral Mucosa in Relation to Shisha Smoking in Syria and Lebanon
khaled
Zaid
Elie
Azar-Maalouf
Charif
Barakat
Mansour
Chantiri
Introduction: Shisha (waterpipe) smoking is becoming a very prevalent form of tobacco consumption in the Middleeast and use is growing over the world. Smoking-related malignancies have a high genome-wide burden of mutations,including examples in the gene encoding p53. Aims: To investigate alterations in p53 immunohistochemical expressionin the normal, pre-malignant, malignant oral mucosa in relation to Shisha smoking habits. Materials and Methods:A total of 105 paraffin embedded tissue sections of OSCCs (52 smokers,53 non-smokers), 96 of premalignant lesions(48 smokers,48 non-smokers) and 60 normal oral mucosa. Some 30 patients with a history of Shisha smoking dailyfor more than 5 years were also investigated for mutant expression of p53. Tissue samples were considered positivefor p53 staining when any positive cells of epithelial origin could be detected. Results: The majority (74.3%) of oralsquamous cell carcinomas showed positive staining for p53 expression (83.1% and 65.5% with Shisha smokers andnon-smokers, respectively). In the 96 premalignant lesions, about 23% from non-smokers and 41.7% from smokersshowed p53 positivity. In normal epithelium, P53 positive cells were noted in 6.6% of non-smokers and 16.6% ofsmokers. Positive correlations with Shisha smoking were evident for the following groups: WDOSCC, MDOSCC,mild dysplasia G1, moderate dysplasia G2 and in normal mucosa using Student’s t- test, P valueThese results strongly suggest that p53 mutations are associated with Shisha smoking in OSCC, pre-malignant lesionsand normal mucosa of the oral cavity.
Shisha
Malignancy
oral mucosa
p53
2018
07
01
1879
1882
https://journal.waocp.org/article_65366_aff5b4bca15838e56a6301d144992ee1.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
The Endoscopic and Clinicopathological Characteristics of Early-onset Gastric Cancer in Vietnamese Patients
Duc Trong
Quach
Den Van
Ha
Toru
Hiyama
Aim: To assess the endoscopic and clinicopathological features of early-onset gastric cancer (EOGC) in Vietnamese,a population with intermediate risk of gastric cancer. Patients and methods: Consecutive patients diagnosed withgastric adenocarcinoma were prospectively recruited. The demographic, clinical data in each patient were collected.The location and macroscopic type of all gastric lesions suspected to be malignant were reported according to theJapanese classification. The histologic tumor type of gastric cancer (GC) was classified according to the Laurenclassification. Helicobacter pylori (H. pylori) infection were diagnosed by rapid urease test and urinary H. pyloriantibody test. The infection was diagnosed when at least one of the two tests was positive. Results: The rate of EOGC(i.e. ≤ 40 years of age) was 16.3% (23/141). The median age of patients with EOGC was 35 (range 28 – 40) years andthe male-to-female was 1:1.09. Compared to the older group (i.e. ≥ 50 years of age), the rates of positive family history,H. pylori infection and alarm features in the EOGC group were not significantly different (0.0% vs. 5.4%, p = 0.581;73.9% vs. 66.3%, p = 0.620; and 60.8% vs. 79.3%, p = 0.100; respectively). The EOGC group had significantly higherrate of tumor extending to entire stomach (21.7% vs. 3.4%, p = 0.003); but the rate of diffuse-type GC between the twogroups were not significantly different (87.0% vs. 71.7%, p = 0.181). Conclusions: Vietnamese patients with EOGC hadhigher rate of tumor extending to entire stomach compared to the older group. But the family history of GC, H. pyloriinfection and the pathological characteristics were not significantly different between the two groups. Environmentalfactors which play important roles in the development of EOGC in Vietnam should be investigated in future study.
Early-onset
Gastric cancer
Carcinoma
Vietnam
Helicobacter pylori
2018
07
01
1883
1886
https://journal.waocp.org/article_63505_2dfafc4b2daa63705dd3aee333041794.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Methylation Profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese Women with Breast Cancer
Trang Lan
Vu
Trang Thu
Nguyen
Van Thi Hong
Doan
Lan Thi Thuong
Vo
Objective: This study investigated the DNA promoter methylation profiles of BRCA1, RASSF1A and GSTP1 genes,both individually and in an integrative manner in order to clarify their correlation with clinicopathological parameters ofbreast cancer from Vietnamese patients, and establish new potential integrative methylation biomarkers for breast cancerdetection. Material and methods: The methylation frequencies of BRCA1, RASSF1A and GSTP1 were analyzed bymethylation specific polymerase chain reaction (MSP) in 70 specimens of breast carcinomas and 79 pairs of tumor andmatched adjacent normal tissues from breast cancer patients. Results: All the three analyzed genes showed a concordanceconcerning their promoter methylation in tumor and adjacent normal tissue. The methylation of BRCA1, RASSF1Aand GSTP1 was found in 58.23 %, 74.68 % and 59.49 % of tumor tissues and 51.90 %, 63.29 % and 35.44 % ofcorresponding adjacent tissues, respectively. When each gene was assessed individually, only the methylation ofGSTP1 was significantly associated with tumor tissues (p=0.003). However, the methylation frequency of at least one ofthe three genes and the methylation frequency of all the three genes both showed significant association with tumor(p=0.008 and p=0.04, respectively). The methylation of BRCA1 was found to be significantly associated with tumorgrade (p=0.01). Conclusion: This study emphasized that the panel of the three genes BRCA1, RASSF1A and GSTP1can be further developed as potential biomarkers in diagnosis and classification of breast cancer in Vietnamese women.
Breast cancer 1 (BRCA1)
RAS-association domain family member 1 (RASSF1A), Glutation S-transferase P1 (GSTP1), Methylation Specific Polymerase chain reaction (MSP)
2018
07
01
1887
1893
https://journal.waocp.org/article_63506_84b43913f307bd4de010ebe15d11baf7.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Mesenchymal Stromal Stem Cell-Derived Microvesicles Enhance Tumor Lysate Pulsed Dendritic Cell Stimulated Autologous T lymphocyte Cytotoxicity
Nasim
Rahmani Kukia
Reza
Alipanah-Moghadam
Nowruz
Delirezh
Mohammad
Mazani
Background: Immunotherapy is one promising therapeutic strategy against glioma, an aggressive form of braincancer. Previous studies have demonstrated that multiple tumor antigens exist and can be used to induce tumor specificT cell responses. Furthermore, recently it was shown that TLR4-primed mesenchymal stem cells (MSCs), also knownas MSC1, mostly elaborate pro-inflammatory mediators. Compared to MSCs, MSC-derived microvesicles (MVs) haveadvantageous properties that present them as stable, long lasting effectors with no risk of immune rejection. Therefore,peripheral blood monocyte derived dendritic cells (MoDCs) have been used to load tumor antigens and stimulate Tcell mediated responses in the presence of MSC1-derived MVs in vitro. Methods: The B92 tumor cell line was heatedto 43°C for 90 min prior to preparation of tumor cell lysates. MVs were purified by differential ultracentrifugationafter isolation, stimulation of proliferation and treatment of MSCs. Autologous T cells isolated from non-adherentcells were harvested during the procedure to generate MoDCs and then incubated with heat stressed tumor cell lysatepulsed DCs in the presence of MSC1-derived MVs. T cells were then co-cultured with tumor cells in 96-well plates ata final volume of 200 μl CM at an effector: target ratio of 100:1 to determine their specific cytotoxic activity. Results:Flow cytometric analysis, T cell mediated cytotoxicity showed that heat stressed tumor antigen pulsed MoDCs andMSC1-derived MVs primed T cells elicited non-significantly enhanced cytotoxic activity toward B92 tumor cells(P≥0.05). Conclusion: These findings may offer new insights into tumor antigen presenting technology involvingdendritic cells and MSC1-derived MVs. Further exploration of the potential of such nanoscale particles in immunotherapyand in novel cancer vaccine settings appears warranted.
Glial cells
Tumor cell lysate
Dendritic Cells
MSC1-derived MVs
cancer immunotherapy
2018
07
01
1895
1902
https://journal.waocp.org/article_65367_a7231c8a732b0bd27a47bde4c6565ee9.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Distribution of Chromosomal Abnormalities Commonly Observed in Adult Acute Myeloid Leukemia in Pakistan as Predictors of Prognosis
Muhammad Shariq
Shaikh
Zeeshan Ansar
Ahmed
Mohammad Usman
Shaikh
Salman Naseem
Adil
Mohammad
Khurshid
Tariq
Moatter
Anila
Rashid
Farheen
Karim
Ahmed
Raheem
Natasha
Ali
Objectives: The heterogenous response to treatment in acute myeloid leukemia (AML) can be attributed largely tothe difference in cytogenetic features identified in between cases. Cytogenetic analysis in acute leukemia is nowroutinely used to assist patient management, particularly in terms of diagnosis, disease monitoring, prognosis and riskstratification. Knowing about cytogenetic profile at the time of diagnosis is important in order to take critical decisionsin management of these patients. The study was conducted to determine the distribution of cytogenetic abnormalities inPakistani adult patients with AML in order to have insights regarding behavior of the disease. Methods: A retrospectiveanalysis of all the cases of AML (≥15years old) diagnosed at Aga Khan University from January 2011 to December 2016was performed. Cytogenetic analysis was made for all cases using the trypsin-Giemsa banding technique. Karyotypeswere interpreted using the International System for Human Cytogenetic Nomenclature (ISCN) criteria. Results:A total of 321 patients were diagnosed with AML during the study period, of which 288 samples successfully yieldedmetaphase chromosomes. The male to female ratio was 1.7:1. A normal karyotype was present in 61% (n=176) ofthe cases whereas, 39% (n=112) had an abnormal karyotype. Of the abnormal cases, t (8;21) (q22;q22) and t (15;17)(q22;q12) were identified in 8.3% and 4.9% cases respectively. Adverse prognostic cytogenetic subgroups includingcomplex karyotype, monosomy 7 and t(6;9)(p23;q34) were identified in 9%, 1% and 0.7% patients respectively.Conclusions: This largest cytogenetic data in adult AML from Pakistan showed comparable prevalence of favorableprognostic karyotype to international data. The prevalence of specific adverse prognostic karyotype was low.
AML
cytogenetics
adult
Pakistan
2018
07
01
1903
1906
https://journal.waocp.org/article_63507_2e5da6a3e3a17611922b458161507f7c.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Site of Metastases as Prognostic Factors in Unselected Population of Stage IV Non-Small Cell Lung Cancer
Ahmed
Ashour Badawy
Gehan
Khedr
Abbas
Omar
Sejong
Bae
Waleed
Arafat
Stefan
Grant
Background: Advanced stage non-small cell lung cancer (NSCLC) is a heterogenous disease, yet, with the exception oftargeted therapies, most guidelines recommended uniform treatment irrespective of tumor burden or sites of metastasesand this may explain, in part, the wide range of responses to same lines of therapy. Aim of work: In this work wetried to explore the effect of metastatic sites in on overall survival (OS), in an unselected group of Non-small cell lungcancer patients who received different treatments line. Methods: A retrospective analysis was performed on patientswith stage IV NSCLC who received systemic treatment at UAB Cancer Center (NCI designated comprehensive cancercenter) between 2002 to 2012. The details of sites of metastases, systemic therapy and overall survival were recordedfor each patient. Result: In 409 patients who received systemic treatment, there was statistically significant lower OSin those presenting with liver metastases (p<0.001), adrenal metastases (p=0.011) and metastases to abdominal lymphnodes (p=0.014). There was no statistically significance difference in OS in patient presenting with pleural metastasesor effusion (p=0.908), metastases to heart or pericardium (p=0.654), metastases to bone (p=0.281), brain (p=0.717) orskin and subcutaneous tissue (p=0.642). Conclusion: Intra-abdominal metastases confer a particularly poor prognosisin stage IV NSCLC treated with systemic therapy and may identify patients in whom aggressive treatment beyond firstline therapy is not appropriate.
Lung cancer
Metastases
Prognosis
2018
07
01
1907
1910
https://journal.waocp.org/article_65363_a774bd5543449368d4288c481ec8e6b4.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control Study
Yasuo
Tsuchiya
Kumudesh
Mishra
Vinay K
Kapoor
Ruchira
Vishwakarma
Anu
Behari
Toshikazu
Ikoma
Takao
Asai
Kazuo
Endoh
Kazutoshi
Nakamura
Objective: Gallbladder cancer is the commonest gastrointestinal cancer in northern Indian women. Some studieshave examined the association between Helicobacter pylori infection and gallbladder cancer risk, but findings have beeninconsistent. We aimed to examine the association between H. pylori infection and gallbladder cancer in Indian people.Materials and Methods: We conducted a hospital-based case-control study including 100 gallbladder cancer patientswith gallstones who were 32 to 79 years old (cases; 72 women and 28 men), and 100 cholelithiasis patients aged 14 to75 years (controls; 65 women and 35 men). All patients had a diagnosis of gallbladder cancer or cholelithiasis at theSanjay Gandhi Post Graduate Institute of Medical Sciences in Lucknow having a high gallbladder cancer incidencein northern India, from May 2014 through July 2017. Plasma samples were collected from all patients before surgicaltreatment. Plasma H. pylori antibody titer was measured by the latex agglutination method and an autoanalyzer. H.pylori infection was defined as antibody titer ≥10 U/mL. Plasma antibody titers and H. pylori infection positivity rateswere compared between cases and controls. Results: Mean plasma antibody titers (standard deviation, range) were11.1 U/mL (11.6, 0–78) in cases and 13.6 U/mL (23.0, 1–164) in controls. H. pylori infection positivity rates were41% and 42% in cases and controls, respectively. No significant differences in antibody titers or H. pylori infectionpositivity rates were found between cases and controls. Conclusions: We found no evidence of H. pylori infection asan important risk factor for gallbladder cancer in Indian people.
autoanalyzer
gallbladder cancer
Helicobacter pylori
latex agglutination assay
2018
07
01
1911
1915
https://journal.waocp.org/article_65186_15be0f04d5227d1e6fce2374125e49ec.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Potential of Aucklandia Lappa Decne Ethanolic Extract to Trigger Apoptosis of Human T47D and Hela Cells
S S
Hasson
A S
H Al-Shubi
J Z
Al-Busaidi
M S
Al-Balushi
F L
Hakkim
L
Rashan
G M
Aleemallah
A A
Al-Jabri
Breast and cervical cancers are global health concerns and major cause of deaths among women. Current treatmentssuch as chemotherapy are associated with several drawbacks that limit their effectiveness. Several anticancer remedieshave been found with natural products in the past and the search continues for more examples. Cytotoxic naturalcompounds may have considerable benefits for cancer therapy either in potentiating the impact of chemotherapy orcurtailment of harmful effects. Therefore, discovery and identification of new drugs for breast and cervical cancertreatment are of high priority. The present study addressed the potential role of the ALD (Aucklandia lappa Decne) insuppressing proliferation of T-47D, HeLa and HEp-2 cells in comparison with the non-cancer HCC1937 BL cell line.Treatment with an ALD extract of T-47D, HeLa, and HEp-2 cells resulted in reduction in cell viability in MMT assays.Furthermore, lyophilized ALD principally suppressed cancer cell line growth and proliferation through induction ofeither intrinsic or extrinsic apoptotic pathways as demonstrated by significantly suppressed release of LDH, and NOproduction in a dose-dependent manner, and activation of death receptors in T-47D and HeLa cells but not the HEp-2cell line. Interestingly, lyophilized ALD significantly (p<0.005) repressed the growth of HEp-2 and T-47D cells aftertreatment for 48hrs while 24hrs treatment significantly suppressed T-47D and HeLa cells. We report for the first timethat lyophilized ALD selectively influences apoptosis through alternative apoptotic pathways in both breast and cervicalhuman cancer cells.
breast cancer
Cervical cancer
anticancer activity
Oman
2018
07
01
1917
1925
https://journal.waocp.org/article_65208_404e424b2af9de85567495e72c1f39f7.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Levels of Pro and Anti-inflammatory Citokynes and C-Reactive Protein in Patients with Chronic Periodontitis Submitted to Nonsurgical Periodontal Treatment
Gustavo Fatureto
Escobar
Douglas Reis
Abdalla
Marcela
Beghini
Valeria Bisinoto
Gotti
Virmondes
Rodrigues Junior
Marcelo Henrique
Napimoga
Betania Maria
Ribeiro
Denise Bertulucci Rocha
Rodrigues
Ruchele Dias
Nogueira
Sanivia Aparecida de Lima
Pereira
Aim: to compare the levels of IFN-γ, TGF-β and C-reactive protein (CRP) in healthy patients (HP) and chronicperiodontitis patients (CP) before and seven days after the last session of Non-Surgical Periodontal Treatment (NSPT).Materials and Methods: 40 subjects were divided into two groups: healthy (n= 20), and with chronic periodontitis(n = 20). Serum and gingival crevicular fluid (GCF) were collected from each patient and quantified for IFN-γ,TGF-β and CRP using the enzyme-linked immunosorbent assay (ELISA). Results: IFN-γ was found to be higher inthe GCF of the CP group before NSPT in relation to the HP group (p<0.05), and it had significant higher levels afterseven days of NSPT (p<0.05). The levels of TGF-β in the GCF of CP patients before NSPT were significantly higherwhen compared to HP (p<0.05), but they decreased after seven days of NSPT (p>0.05). Serum CRP levels did not showstatistical difference between CP and HP before or after NSPT. Conclusion: Therefore, our results demonstrated forthe first time that NSPT causes early exacerbation of the immune response at the local level represented by increasedlevels of IFN-γ and decreased levels of TGF-β in the gingival crevicular fluid after seven days of treatment.
C-reactive protein
Cytokines
immune system
Inflammation
Periodontitis
2018
07
01
1927
1933
https://journal.waocp.org/article_64808_60cf942f3519f765423f649b7f5d8b3a.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Distribution based Fuzzy Estimate Spectral Clustering for Cancer Detection with Protein Sequence and Structural Motifs
Thenmozhi
K
Karthikeyani Visalakshi
N
Shanthi
S
Objective: In biological data analysis, protein sequence and structural motifs are an amino-acid sequence patternsthat are widespread and used as tools for detecting the cancer at an earlier stage. To improve the cancer detection withminimum space and time complexity, Distribution based Fuzzy Estimate Spectral Clustering (DFESC) technique isdeveloped. Methods: Initially, the protein sequence motifs are taken from dataset to form the cluster. The Distributionbased spectral clustering is applied to group the protein sequence by measuring the generalized jaccard similaritybetween each protein sequences. To develop the clustering accuracy, soft computing technique namely fuzzy logic isapplied to calculate membership value of each sequence motifs. Results: The outcome showed that the presented DFESCtechnique effectively identifies the cancer in terms of clustering accuracy, false positive rate, and cancer detection timeand space complexity. Conclusion: Based on the observations, evaluation of DFESC technique provides improvedresult for premature detection of cancer using protein sequence and structural motifs.
Protein Sequence Motifs
Cancer Detection
Distribution Based Spectral Clustering
Generalized Jaccard Similarity
Soft Computing
2018
07
01
1935
1940
https://journal.waocp.org/article_63535_5e889264c6ff1acd771db74b7e654938.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Health Damaged Context: Barriers to Breast Cancer Screening from Viewpoint of Iranian Health Volunteers
Hossein
Safizade
Sara
Hafezpour
Parvin
Mangolian Shahrbabaki
Background: Breast cancer is common among cancer diseases and the second leading cause of death among womenworldwide. The breast cancer-caused death is directly associated with diagnosis time of the disease. Screening is one ofthe major methods for health promotion in human societies. However, many women still refuse to do the periodicscreening. The present study is aimed to analyze the experiences of health volunteers in order to understand the barriers tobreast cancer screening among women at southeast of Iran. Methods: Data collection was performed through focusgroups. Using the purposive sampling method, 24 participants were selected and then were allocated to 6-membergroups. The data were analysed using Lundman and Graneheim qualitative content analysis. Results: The main theme of“Health Damage Context” was extracted with four main categories, including: family barriers, cultural and social barriers,personal barriers and organizational barriers. Conclusion: Based on the results of the present study, there are numerousbarriers to regular breast cancer screening, and for the same reasons, the willingness to screening is sometimes notsatisfactory. Therefore, in case of the women’s referral to health centers, nurses and other health-care professionalsshould inform them about the role of different screening methods in early diagnosis and rapid treatment of breast cancer.
breast cancer
Screening
barrier
health volunteers
Prevention
2018
07
01
1941
1949
https://journal.waocp.org/article_64824_378315f1d9b1130573ae229c787bd003.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
National Burden of Cancers Attributable to Secondhand Smoking in Indonesia
Ni Putu Ayu Linda
Permitasari
Satibi
Satibi
Susi Ari
Kristina
Background: The high prevalence of smokers in Indonesia is also increase the number of people as secondhandsmokers. Secondhand smoke causes many health problems, including cancer. Thus, Indonesia will bear large numbercancer burden of disease, but research on cancer related to secondhand smoking in Indonesia still does not exist.Therefore, this study aimed to determine the number of secondhand smoke attributable fractions (SAFs) of six cancers(lung, bladder, colorectal, stomach, pancreas and larynx) and burden of cancer caused by secondhand smoking inIndonesia using Disability Adjusted Life Years (DALYs) indicator. Material and Methods: This research was usingdescriptive epidemiological prevalence-based research design, with cancers prevalence data gained from Indonesianhealth assurance system database in 2016. The SAFs is calculated by combining both data of secondhand smokingprevalence and relative risk and the DALY indicator is calculated as the sum of years of life lost due to prematuremortality (YLL) and the equivalent healthy years lost due to disability (YLD). Results: Based on SAFs proportion,the highest SAFs among men were in pancreas cancer (80.20%), stomach cancer (79.54%) and laryngeal cancer(69.61%), whereas in women, pancreas cancer (78.95%), stomach cancer (78.26%) and bladder cancer (63.30%).Meanwhile, burden priorities for Indonesian men and woman were lung cancer (110,491), colorectal (68,131), andbladder cancer (39,140). Conclusions: In total, DALYs 6 cancer diseases due to secondhand smoke analyzed in thisstudy were 283,360 DALYs. Thus, the results of the research can be used as a basis for further policies making onnational cigarette prevention and control in Indonesia.
burden of disease
secondhand smoke
cancer
DALYs
Indonesia
2018
07
01
1951
1955
https://journal.waocp.org/article_64832_fe5c641cb1f16f56c1b7a85c09ec1e62.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Exopolysaccharide from Marine Bacillus velezensis MHM3 Induces Apoptosis of Human Breast Cancer MCF-7 Cells through a Mitochondrial Pathway
Mahgoub M
Ahmed
Manal G
Mahmoud
Manal S
Selim
Mohamed E
EL Awady
Objective: The production of new natural pharmaceutical agents that increase the efficiency of chemotherapywithout affecting the normal cells is the goal of all researchers. Therefore, the present study expects to evaluatethe antioxidant and anticancer studies against MCF-7 cell lines of EPS produced by novel Egyptian marine bacterialstrain. Methods: Marine bacterium was isolated, purified and identified by 16S rRNA gene amplification and sequenceanalyses. MHMEPS (the produced EPS) was analyzed by Fourier Transform Infra-red (FTIR), monosugars identificationby HPLC, molecular weight estimation and sulfur content were determined. While, in-vitro antioxidants characterswas determined using various methods and anticancer studies against MCF-7 cell lines. Results: Bacillus velezensisMHM3 produced 5.8 g/L of MHMEPS. The chemical analysis of MHMEPS showed 24% uronic acid and 18.19%sulfate and monosugars glucuronic acid, glucose, fructose and rhamnose with molar ratio of 4.00: 2.00: 1.00: 0.13,correspondingly, with an overall weight average molecular weight Mw of 1.145×104 g/mol and the number average ofmolecular weights Mn of 5.155 ×103 g/mol. The FTIR analysis and periodate oxidation indicate the existence ofα-(1–4) linkage acidic polysaccharide. MHMEPS showed antioxidant scavenging activity against DPPH•, H2O2 andMetal chelating activity, respectively. So, reducing power method give high activity at 500 μg/ml. MHMEPS hinderthe proliferation of MCF-7 cells at 5-80 μg/ml compared to the control group. Moreover, induced apoptosis wasassociated with activation of caspase-3. Also increased cytochrome C levels significantly in a dose-dependent mannercompared with the control. The Caspase-3 activity was raised in MHMEPS treated MCF-7 cells compared withthe control (p<0.05) in a dose-dependent manner. Therefore, the result of DNA fragmentation was confirmed by DNAladder assay. We presume that MHMEPS has high potential at its low concentration, as a novel restorative agent forthe treatment of MCF-7 cells, with no cytotoxicity against normal cells.
Exopolysaccharides
Bacillus velezensis MHM3
Apoptosis
MCF-7 Cells
2018
07
01
1957
1963
https://journal.waocp.org/article_64825_593bd060e2c076c1c0ec82a5086e2b7e.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Proliferative Activity of Myoepithelial Cells in Normal Salivary Glands and Adenoid Cystic Carcinomas Based on Double Immunohistochemical Labeling
Faisal
Alali
Nabil
Kochaji
Objective: To investigate the proliferative activity of myoepithelial cells (MEC) in normal salivary glands (NSG)and adenoid cystic carcinomas (ACC)) Study design. Twenty -three salivary gland specimens (13 ACC, 10 NSG)were studied using double immunohistochemical labeling for α smooth muscle actin (a-SMA) and proliferative cellnuclear antigen (PCNA)). Results: There was a significant difference in PCNA reactivity in normal samples betweenmyoepithelial cells of the parotid glands and of the submandibular glands, rates being higher in the latter. Neoplasticmyoepithelial cells exhibited higher expression than neoplastic epithelial cells. In addition, myoepithelial cells of thecribriform type of ACC showed PCNA reactivity lower than those of the tubular type, whereas there was no statisticallysignificant difference in epithelial cell rates. We could not identify myoepithelial cells in solid pattern due to α-SMAnegativity; although high PCNA reactivity was evident. Conclusion: These data suggest that the myoepithelial cell has akey role in ACC oncogenesis, more so than its epithelial cell counterparts. Moreover, the data provide a histopathologicalinterpretation for aggressive clinical features of submandibular ACC, as the myoepithelial cells were less differentiatedas compared to those of parotid glands.
myoepithelial cell
adenoid cystic carcinoma
PCNA
α-SMA
double immunohistochemical labeling
2018
07
01
1965
1970
https://journal.waocp.org/article_65368_6d7af8c67ccc8000b05848efc436143a.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters
Ranjana
Solanki
Natasha
Agrawal
Maryem
Ansari
Shashank
Jain
Arpita
Jindal
Objective: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma deaths inwomen. Its etiology is multifactorial, implicating reproductive factors, hormonal imbalances and genetic predispositions.Studies have shown that Cycloxygenase-2 (COX-2) plays an important role in the carcinogenesis and increased expressionhas been regarded as a poor prognostic factor. The objective of our study is 1. To study COX-2 expression in normalbreast tissue, DCIS and invasive breast cancer. 2. To determine COX-2 expression with clinicopathological prognosticparameters. Methods: Radical mastectomy specimens were studied for COX-2 expression by immunohistochemistryin 50 patients diagnosed as breast carcinoma. COX-2 expression is quantified as IHS Score and separately calculatedfor normal breast epithelium near the tumor, DCIS and invasive areas. Relationship between COX-2 expression withvarious clinicopathological parameters was evaluated. Result: The results of our study suggest an association of theexpression of COX-2 to the factors associated with poor prognosis in breast cancer, such as larger tumor size, positivelymph node status, higher T stage and N stage and lymphovascular invasion. There was a higher COX-2 expressionin the DCIS component as compared to the invasive ductal carcinoma component and the adjoining breast epithelium.Conclusion: Our study established the role of COX-2 in carcinogenesis and its association with adverse prognosticfactors.
COX-2
IDC
DCIS
2018
07
01
1971
1975
https://journal.waocp.org/article_64823_2a8fbd2864efd2e4b3d1569875985c2f.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Evaluation of Therapeutic Potential of Eugenol-A Natural Derivative of Syzygium aromaticum on Cervical Cancer
Arunava
Das
Harshadha
K
Dhinesh Kannan
S K
Hari Raj
K
Bindhu
Jayaprakash
Background: The intendment of this study is to determine the pursuance in – vitro anticancer activity andcytotoxicity of Syzygium aromaticum against the human cervical cancer cell line (HeLa) compared to the normal celllines. Apoptogenic properties of DCM extract of Eugenol was determined in this entire study. Materials and Methods:HeLa cell lines were cultured in DMEM medium and incubated with different concentration of DCM – Eugenolextract. MTT assay brought out the way to determine the cell viability and quantification was done with the opticalabsorbance at 570 nm and 620 nm as reference. Apoptotic cells were affirmed by dual staining using acridine orangebromide. Besides, the morphology of the nucleus was also confirmed by dual staining. Eugenol inhibited 50% growth(IC50) of HeLa cell lines at 200 mg/ml of extract concentration. Results: Inhibitory efficacy of eugenol isolated fromSyzyzgyium aromaticum showed the cell – viability in time and dose dependent manner with consistent morphologicalchanges. Flow cytometer determined the apoptosis confirming the cytotoxicity value for MTT at IC50 with 81.85% cellviability. Dual staining firmly enacts the damaged cells due to AO indicating apoptosis confirmation by dual staining.Morphological analysis also clearly states that nil apoptosis has been seen in control and similarly in eugenol treatedwhen compared to cancerous HeLa cell – line. Conclusion: Evaluation of cytotoxicity effect of eugenol isolated fromSyzygium aromaticum showed it can be unrivalled dormant source of prodigious changes in HeLa cell line indicating(revealing) that chemotherapeutic agent.
Syzygium aromaticum
HeLa Cell Line
MTT
HPLC
Eugenol
2018
07
01
1977
1985
https://journal.waocp.org/article_64826_f598cf196893c478291ce0debede93b9.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Toxoplasmosis an Overlooked Disease: Seroprevalence in Cancer Patients
Raafat
Abdel-Malek
Rita
Wassef
Enas
Rizk
Hoda
Sabry
Nevine
Tadros
Abdallah
Boghdady
Background: Toxoplasmosis is one of the most important cosmopolitan life-threatening diseases in immunecompromisedpatients. It is caused by an intracellular protozoon: Toxoplasma gondii (T. gondii). The parasite can causepneumonia, encephalitis or disseminated disease in immune-deficient patients and dangerous congenital anomaliesin infants born to mothers infected during early pregnancies. The present study aims to evaluate the prevalence oftoxoplasmosis in Egyptian cancer patients and to correlate the prevalence with type of malignancy and the differentcancer treatment modalities. Materials and Methods: Blood samples from 150 cancer patients and 50 control subjectshave been examined for presence of anti-toxoplasma antibodies using a lateral flow chromatographic immunoassay.Results: Among cancer patients included in this study, the prevalence of anti- T.gondii antibodies was 20% for IgGand 4% for IgM, while in the control group it was 8% and 2% in the same order. This difference was statisticallysignificant for IgG (P =0.003) but not for IgM (P = 0.44). Patients with solid organ tumors treated with chemotherapyhad the highest prevalence rate of toxoplasmosis (28%). It was also found higher in males (26%) than females (10%)and higher among urban (18%) than rural dwellers (16%). Conclusion: Cancer patients showed a significantly higherrate of infection with T. gondii than their cross-matched control. For that reason, we recommend the inclusion of ascreening test for toxoplasmosis in their routine workup.
cancer
Chemotherapy
Prevalence
Radiation
Toxoplasma gondii
2018
07
01
1987
1991
https://journal.waocp.org/article_65364_17091e779d409855fa486ca2b0f41018.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Investigating the Effect of Mindfulness-Based Training on Psychological Status and Quality of Life in Patients with Breast Cancer
Somye
Pouy
Fatemeh
Attari Peikani
Hassan
Nourmohammadi
Parisa
Sanei
Asma
Tarjoman
Milad
Borji
Cancer poses substantial challenges to both physical and mental health of patients. On the other hand, breast canceris one of the most common cancers among Iranian women. Therefore, the present study was conducted to investigatethe effect of mindfulness-based training on psychological status and quality of life (QoL) of patients with breast cancerliving in Ilam, Iran. This quasi-experimental study was performed on 66 patients diagnosed with breast cancer. Thepatients assigned into two groups of experimental and control. Experimental group received mindfulness-based grouptraining through eight 90-min sessions. Sessions were conducted twice a week and were completed within 1 month.The research tools included a QoL questionnaire (WHOQOL-BREF), Schneider’s life expectancy questionnaire, andthe depression anxiety stress scale (DASS-21). The questionnaires were completed before and during the interviewswith the patients 2 months after intervention. Data were analyzed using SPSS (version 16) and running descriptive andanalytical statistics. Before the intervention, there was no significant difference between he experimental and controlgroups considering QoL, life expectancy, depression, anxiety, and stress (p>0.05). However, after the intervention, thepatients in the experimental group reported higher QoL and life expectancy and less severe depression, anxiety, andstress (p < 0.05). Considering the positive effect of mindfulness-based training on the psychological status and QoLof patients with breast cancer, we recommend health nurses conduct mindfulness-based training for patients receivingclinical care services.
Keywords: Cancer
Mindfulness-basedTraining
Quality of Life
Psychological Problems
2018
07
01
1993
1998
https://journal.waocp.org/article_64829_d17bf34e3958d5b8369ef4eb0b8d2fd1.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Dietary Inflammatory Index and Odds of Colorectal Cancer in a Case- Control Study from Iran
Nitin
Shivappa
James
R Hebert
Susan
E Steck
Akram
Safari
Fatemeh
Sedaghat
Bahram
Rashidkhani
Background: In Iran, colorectal cancer (CRC) is the third and fourth leading cause of cancer incidence among menand women, respectively. Diet and inflammation have been suggested as important risk factors for CRC. We examinedthe association between dietary inflammatory index (DII) scores and CRC in a case-control study conducted in Iran.Methods: This study included 71 CRC cases and 142 controls hospitalized for acute non-neoplastic diseases. DIIscores were computed from dietary intake assessed by a previously validated food frequency questionnaire. Logisticregression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) adjusted for age, sex,education, energy intake, exercise, body mass index (BMI), smoking, family history of cancer, and history of aspirin,acetaminophen, and multivitamin use. Results: Subjects with higher DII scores (i.e., indicating a more pro-inflammatorydiet) had a higher odds of CRC with the DII being used as both a continuous variable (OR continuous = 2.20, 95% CI:1.22-3.87) and as a categorical variable (OR tertile 3 vs tertile1 = 2.47, 95%CI: 1.10-5.55). Conclusion: These resultsindicate that a pro-inflammatory diet is associated with increased odds of CRC in this Iranian population.
Dietary Inflammatory Index
colorectal cancer
Case-control
2018
07
01
1999
2006
https://journal.waocp.org/article_64806_1c8978db548e6afeb97c3d7103d2f9da.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Preoperative Evaluation of Tumor Adhesion to Adjacent Brain Tissue in Patients with Meningioma with BSMI Method and Its Comparison with the Width of Edema Around Tumor
Sonia
Rezaei
Fariborz
Faeghi
Mohammad
Samadian
Babak
Shekarchi
Background: This study aims to investigate the ability of BSMI, to preoperative evaluation of tumor adhesion toadjacent brain tissue in patients with meningioma and comparing this method to the width of edema around tumor, usingsurgery findings as the reference standard. Methods: Thirty patients with meningioma brain tumor who underwentsurgery at Loghman hospital were selected for the study between November 2016 and January 2018. The level ofedema according to the classification of Ide et al., (u1995) was compared with the surgical findings with blinded results,and neurosurgeons made a qualitative assessment of tumor adhesion at the time of resection. The ability of BSMI andlevel of edema to predict the surgical assessment of adhesion was tested using the Fisher Exact Test. Results: BSMImethod was conducted on patients with meningioma brain tumor, which judged 22 (73.3%) patients as adhesion (+)and 8 (26.66%) patients as adhesion (-). In this case, there was a significant relationship between BSMI judgment andsurgical findings (p-value<0.0001). The sensitivity, specificity, precision and accuracy was high, at 91.30%, 85.71%,95.45% and 90%, respectively. Using T2-Weighted SPACE sequence, of the 30 patients, 13 (43.3%) were judged asadhesion (+) and 17 (56.7%) as adhesion (-) from edema, whereas surgical findings evaluated 23 (76.7%) as adhesion(+) and 7 (23.3%) as adhesion (-).The sensitivity was moderate but the specificity was high, at 52.17% and 85.71%,respectively. Other criteria such as precision and accuracy were 62.31% and 60%, respectively. Conclusions: BSMIevaluated adhesion of the tumor to the adjacent brain tissue with high-accuracy prior to surgery. This method was moreeffective than Edema method in evaluating adhesion between meningioma and the brain.
meningioma
Adhesion
Magnetic resonance imaging
2018
07
01
2007
2012
https://journal.waocp.org/article_65159_1aa31c5678f59f88300eeefae61efbca.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Detection of Risk Groups for Carcinogenic Liver Fluke Infection by Verbal Screening Questionnaire Using a Mobile Application
Natthawut
Kaewpitoon
Soraya J
Kaewpitoon
Thirayu
Meererksom
Siwawich
Chan-Aran
Wararat
Sangwalee
Jirawoot
Kujapan
Jun
Norkaew
Jirayut
Chuatanam
Sukanya
Ponphimai
Mali
Pothipim
Natnapa
Padchasuwan
Taweesak
Tongtawee
Likit
Matrakool
Sukij
Panpimanmas
Ryan A
Loyd
Parichart
Wakkhuwattapong
The carcinogenic liver fluke, Opisthorchis viverrini, is a serious health problem in Southeast Asia where infectionis associated with cholangiocarcinoma, a major cause of death in Thailand. This cross-sectional study aimed to screenfor O. viverrini infection among a Thai rural population of 560 individuals from Nakhon Ratchasima, Khonkaen, andChaiyaphum provinces with a verbal screening test with a mobile application (OvApp). Faecal samples were alsoprocessed with a mini-parasep sf parasite faecal concentrator. The infection rate of O. viverrini was found to be 2.86%.The majority of infections were detected in males aged 41–50, with primary school being their highest education level, andwho were engaged in agricultural occupations. In screening for O. viverrini infection, the OvApp had a high sensitivity(87.5%), specificity (94.6%), negative predictive value (98.9%), and accuracy (98.6%). The positive predictive valuewas 70.0% for the OvApp. The observed agreement was substantial for this application (k-value = 0.64) indicated thatit is a potentially useful tool for decreasing the cost of large-scale O. viverrini screening.
Opisthorchis viverrini
OvApp
Verbal screening questionnaire
Thailand
Mobile Application
2018
07
01
2013
2019
https://journal.waocp.org/article_65160_8fd4d08971593480a12fdd1cb31b7002.pdf
Asian Pacific Journal of Cancer Prevention
Asian Pac J Cancer Prev
1513-7368
1513-7368
2018
19
7
Access to Health Care, Beliefs, and Behaviors about Colorectal Cancer Screening among Korean Americans
Shin Young
Lee
Eunice E
Lee
Background: Colorectal cancer (CRC) is one of the most common cancers among Korean Americans (KAs) andtheir CRC screening rates are low. To raise the rates of CRC screening among KAs, it is necessary to improve ourunderstanding of factors that influence their CRC screening behaviors. This study examined socio-demographics,access to health care, health and cultural beliefs, and behaviors about the fecal occult blood test (FOBT) for CRCscreening among KAs aged 50 and older. Methods: Based on the health belief model, the cultural assessment modelfor health, and the Powe fatalism model, this study measured socio-demographics (age, gender, years in the U.S.,marital status, education, employment, income, and acculturation), health care access (health insurance, having aregular doctor, physician recommendation, and trust in doctor), health beliefs (susceptibility, severity, benefits, barriers,and self-efficacy), and cultural beliefs (physical space, health temporal orientation, personal control, and fatalism)and FOBT. A cross-sectional survey (n=202) was conducted. Data analysis was conducted using descriptive analysis,Pearson correlation, and multivariate logistic regression. Results: This study found that physician recommendationwas the strongest factor in lifetime FOBT utilization in KAs. The results also revealed a positive association amonghealth temporal orientation, health fatalism, and lifetime FOBT among KAs, while previous research found a negativeassociation between fatalism and cancer screening. Years in the U.S., employment, and having a regular doctor weresignificantly associated with having had a FOBT in the previous year. Conclusion: Study results suggested the need forpublic education programs to increase physician recommendation among KAs. Furthermore, the positive relationshipsamong health temporal orientation, health fatalism, and FOBT utilization in KAs suggests that KAs have a desire tomaintain health and find cancer early despite their fatalistic view on health.
colorectal cancer
beliefs
Screening
Korean Americans
2018
07
01
2021
2027
https://journal.waocp.org/article_65361_355d1c2bb2141d5bafb31a70d72c7240.pdf