West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Curcumin: a Polyphenol with Molecular Targets for Cancer Control2735273916296APJCP.2016.17.6.2735ENMuhammad ImranQadirInstitute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, PakistanSyeda Tahira QousainNaqviSyed AunMuhammadMuhammadQadirInstitute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, PakistanSyeda TahiraNaqviInstitute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, PakistanSyed AunMuhammadInstitute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, PakistanJournal Article19700101Curcumin, is a polyphenol from <em>Curcuma longa </em>(turmeric plant), is a polyphenol that belongs to the ginger family which has long been used in Ayurveda medicines to treat various diseases such as asthma, anorexia, coughing, hepatic diseases, diabetes, heart diseases, wound healing and Alzheimer’s. Various studies have shown that curcumin has anti-infectious, anti-inflammatory, anti-oxidant, hepatoprotective, thrombosuppressive, cardio protective, anti-arthritic, chemo preventive and anti-carcinogenic activities. It may suppress both initiation and progression stages of cancer. Anticancer activity of curcumin is due to negative regulation of inflammatory cytokines, transcription factors, protein kinases, reactive oxygen species (ROS) and oncogenes. This review f ocuses on the different targets of curcumin to treat cancer.https://journal.waocp.org/article_16296_a362663663e67cc5480e6df239532cf7.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Cancer Research Advances Regarding the CKLF-like MARVEL Transmembrane Domain Containing Family2741274416297APJCP.2016.17.6.2741ENJiaLuSchool of Basic Medical,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaQian-QianWuSchool of Stomatology,The Fourth Hospital of Hebei Medical University , Shijiazhuang, Hebei, ChinaYa-BoZhouSchool of Public Health,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaKai-HuaZhangSchool of Basic Medical,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaBing-XinPangSchool of Basic Medical,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaLiangLiSchool of Basic Medical,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaNanSunDepartment of Blood Transfusion,The Fourth Hospital of Hebei Medical University,Shijiazhuang, Hebei,ChinaHeng-ShuWangDepartment of Pathology, The Second Hospital of Hebei Medical University,Shijiazhuang, Hebei,ChinaSongZhangDepartment of Clinical
Laboratory, The Third Affiliated Hospital, Shijiazhuang, Hebei,ChinaWen-JianLiDepartment of Immunology,Hebei Medical UniversityKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, ChinaWeiZhengDepartment of Surgical Oncology, Chinese
PLA General Hospital, Beijing, ChinaWeiLiuDepartment of Immunology,Hebei Medical UniversityKey Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, ChinaJournal Article19700101The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products act between chemokines and the transmembrane-4 superfamily. Located in several human chromosomes, the CMTMs CKLF and CMTM1 to CMTM8 may be unregulated in tumors and act as potential tumor suppressor genes with important roles in the immune, male reproductive and hematopoietic systems. In-depth studies in recent years established a close relation between CMTMs and tumorigenesis and metastasis. The CMTM family has a significant clinical value in diagnosis and treatment of diseases linked to tumors and the immune system.https://journal.waocp.org/article_16297_8cb931526c1da7d0abc413043f363df7.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review)2741274423626ENJiaLuSchool of Basic Medical Hebei Medical University, Beijing, ChinaQian-QianWuYa-BoZhouKai-HuaZhangBing-XinPangLiangLiNanSunHeng-ShuWangSongZhangWen-JianLiWeiZhengWeiLiuJournal Article19700101CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products are between chemokines and the transmembrane-4 superfamily. Loaceted in several human chromosomes, CMTMs, which are unregulated in kinds of tumors, are potential tumor suppressor genes consisting of CKLF and CMTM1 to CMTM8. CMTMs play important roles in immune, male reproductive and hematopoietic systems. Also, it has been approved that CMTM family has strong connection with diseases of autoimmunity, haematopoietic system and haematopoietic system. The in-depth study in recent years found the close relation between CMTMs and umorigenesis, tumor development and metastasis. CMTM family has a significant clinical value in diagnosis and treatment to the diseases linking to tumor and immune system.West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Etiopathogenesis of Gastric Cancer2745275016298APJCP.2016.17.6.2745ENVedatGoralDepartment of Gastroenterology, Medical Faculty, Izmir University, Izmir, Turkey0000000221970466VedatGoralDepartment of Gastroenterology, Medical Faculty, Izmir University, Izmir, Turkey *For correspondence: vegoral@hotmail.comJournal Article19700101Gastric cancer is a multifactorial and complex malignant disease seen commonly worldwide. It is one of the few malignant conditions in which the etiology involves infectious agents (<em>Helicobacter pylori)</em>, but there are many other risk factors incuding high salt intake. Its pathogenesis generally involves interactions between environmental factors and genetic disposition. It is currently onsidered that stem cells may play a central role in gastric cancer development.https://journal.waocp.org/article_16298_923d7bbe3a1849ce6fb7a9c29e009242.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Melanoma in Iran: a Retrospective 10-Year Study2751275516301APJCP.2016.17.6.2751ENSamiraFerdosiGroup of Genetics, Cancer Research Center, Cancer Institute of Iran,Tehran University of Medical Sciences (TUMS), Tehran, IranMojtabaSaffariGroup of Genetics, Cancer Research Center, Cancer Institute of Iran,Tehran University of
Medical Sciences (TUMS), Tehran, IranDepartment of Genetics, Faculty
of Medicine, Tehran University of
Medical Sciences (TUMS), Tehran, IranShararehEskandariehBrain
and Spinal Cord Injury Research Center,Neuroscience Institute, Tehran University of Medical Sciences (TUMS), Tehran, IranMS Research Center, Neuroscience Institute, Tehran University of Medical Sciences (TUMS), Tehran, IranRaziyehAlishahiGroup of Genetics, Cancer Research Center, Cancer Institute of Iran,Tehran University of
Medical Sciences (TUMS), Tehran, IranMahsaGhaffari MoghaddamGroup of Genetics, Cancer Research Center, Cancer Institute of Iran,Tehran University of
Medical Sciences (TUMS), Tehran, IranAlirezaGhanadanDepartment of Dermatopathology, Razi Hospital, Tehran University of
Medical Sciences (TUMS), Tehran, IranRezaShirkoohiGroup of Genetics, Cancer Research Center, Cancer Institute of Iran,Tehran University of
Medical Sciences (TUMS), Tehran, IranJournal Article19700101<span style="text-decoration: underline;">Background</span>: Melanoma, the most life-threatening type of skin cancer, is a malignant tumor initiating in melanocytes that rapidly metastasizes and causes death.<br /> <span style="text-decoration: underline;">Materials and Methods</span>: In this retrospective study, samples were selected from patients’ information files in our Cancer Institute in Tehran with a designed checklist. A total of 322 files were found from 2003 until 2012. Then the raw data were transferred to Statistical Package for Social Sciences (SPSS) software version 16 and additional analysis was performed by Students t-test. The important variables were considered according to the available information from history of pathology including age, gender, occupation, stage and location of tumor.<br /> <span style="text-decoration: underline;">Results</span>: Our data showed that incidence of melanoma has been different in the studied 10-year period according to age. Also, incidence of melanoma was higher in men than women. It was more common in lower limbs. More commonly housewives among women and farmers among men were affected by melanoma.<br /> <span style="text-decoration: underline;">Conclusions</span>: Taken together the descriptive data clarified general aspects of this disease for further screening and interventions.https://journal.waocp.org/article_16301_927d243e0cbdc87a6e467620fbfe7a2f.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Hypermethylation Status of E-Cadherin Gene in Gastric Cancer Patients in a High Incidence Area2757276016302APJCP.2016.17.6.2757ENHaroonRashidDepartment of General and minimal invasive surgery, Sher-I- Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, IndiaHaroonRashidDepartment of General and Minimal Invasive Surgery,Soura, Srinagar, Kashmir, IndiaEqual contributorsKhursheedAlamDepartment of General and Minimal Invasive Surgery,Soura, Srinagar, Kashmir, IndiaEqual contributorsDilAfrozeDepartment of Immunology and Molecular Medicine, Soura, Srinagar, Kashmir, IndiaAdfarYousufDepartment of Immunology and Molecular Medicine, Soura, Srinagar, Kashmir, IndiaManzoorBandayDepartment of Medical Oncology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, IndiaFizalahKawoosaDepartment of Immunology and Molecular Medicine, Soura, Srinagar, Kashmir, IndiaJournal Article19700101Gastric cancer (GC) is the fourth most prevalant cancer and the second leading cause of cancer-related mortality worldwide. As in other cancers gastric carcinogenesis is multifactorial involving environmental, genetic and epigenetic components. Epigenetic silencing due to hypermethylation of tumour suppressor genes is one of the key events in gastric carcinogenesis. This study was aimed to analyse the hypermethylation status of the E-Cadherin (<em>CDH1</em>) gene promoter in GCs in the ethnic Kashmiri population. In this study a total of 80 GC patients were recruited. Hypermethylation in tumour tissue was detected by methylation specific PCR (MS-PCR). Hypermethylation of <em>CDH1 </em>promoter was observed in 52 (65%) of gastric carcinoma cases which was significantly much higher than adjacent normal tissue [p≤0.0001]. Further the frequency of <em>CDH1 </em>promoter methylation was significantly different with intestinal and diffuse types of gastric cancer [55.7% vs 82.1%; p<0.05]. Moreover females and cases with lymph node invasion had higher frequencies of <em>CDH1 </em>hypermethylation [P≤0.05]. Thus the current data indicate a vital role of epigenetic alteration of <em>CDH1 </em>in the causation and development of gastric cancer, particularly of diffuse type, in our population.https://journal.waocp.org/article_16302_835e680f24a3d5ea65a282cce99893c8.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Raw Fish Consuming Behavior Related to Liver Fluke Infection among Populations at Risk of Cholangiocarcinoma in Nakhon Ratchasima Province, Thailand2761276516303APJCP.2016.17.6.2761ENWasugreeChavengkunFaculty of Public Health, Institute of Medicine, Suranaree University, Nakhon Ratchasima0000-0002-2806-2129WasugreeChavengkunFaculty of Public Health, Vongchavalitkul University, Khon Kaen Univeristy, Khon Kaen, ThailandPontipKomporFaculty of Public Health, Vongchavalitkul University, Khon Kaen Univeristy, Khon Kaen, ThailandJunNorkaewFaculty of Public Health, Vongchavalitkul University, Khon Kaen Univeristy, Khon Kaen, ThailandJirawootKujapunFaculty of Public Health, Vongchavalitkul University, Khon Kaen Univeristy, Khon Kaen, ThailandMaliPothipimFaculty of Public Health, Vongchavalitkul University, Khon Kaen Univeristy, Khon Kaen, ThailandSukanyaPonphimaiFaculty of Public Health, Vongchavalitkul University, Khon Kaen Univeristy, Khon Kaen, ThailandSorayaKaewpitoonSchool of Family Medicine and Community Medicine Khon Kaen Univeristy, Khon Kaen, ThailandParasitic Disease Research Unit, Khon Kaen Univeristy, Khon Kaen, ThailandSuranaree University of Technology Hospital, Institute of Medicine, Suranaree University, Nakhon Ratchasima, Khon Kaen Univeristy, Khon Kaen, ThailandNatnapaPadchasuwanFaculty
of Public Health, Khon Kaen Univeristy, Khon Kaen, ThailandNatthawutKaewpitoonFaculty of Public Health, Vongchavalitkul University, Khon Kaen Univeristy, Khon Kaen, ThailandParasitic Disease Research Unit, Khon Kaen Univeristy, Khon Kaen, ThailandSuranaree University of Technology Hospital, Institute of Medicine, Suranaree University, Nakhon Ratchasima, Khon Kaen Univeristy, Khon Kaen, ThailandJournal Article19700101Opisthorchiasis is a health problem in rural communities of Thailand, particularly in the northeast and north regions. Therefore, this study aimed to investigate raw fish consuming behavior related to liver fluke infection among the population at risk for opisthorchiasis and cholangiocarcinoma (CCA). A cross-sectional descriptive study was conducted in Meuang Yang district, Nakhon Ratchasima province, northeast Thailand, between June and October 2015. Participants were screened for CCA, and samples who had a high score of CCA risk were purposively selected. A predesigned questionnaire was utilized to collect the data from all participants. X2-test was used for analysis of associations between demographic data and raw fish consumption. The results revealed that participants had past histories of stool examination (33.0%), liver fluke infection (21.0%), praziquantel use (24.0%), raw fish consumption (78.0%), relatives family consuming raw fish (73.0%), and relatives family with CCA (3.0%). Participants consumed several dished related to liver fluke infection, mainly raw fermented fish (13.0%), under smoked catfish (5.00%), raw pickled fish (4.00%), and raw spicy minced fish salad (3.00%). The most common types of cyprinoid fish were <em>Barbodes gonionotus </em>(39%), <em>Hampala dispar </em>(38%), <em>Puntius brevis </em>(37%), <em>Cyclocheilichthys armatus </em>(33%), <em>Puntioplites proctozysron </em>(32%), and <em>Luciosoma bleekeri </em>(30%), respectively. Participants had a low level of knowledge (mean=3.79, SD=0.74), moderate attitude (mean=7.31, SD=7.31) and practice (mean=38.64, SD=6.95) regarding liver fluke prevention and control. Demographic variables like age (>36 years old; X2-test=17.794, p-value=0.001), education (primary school; X2-test=18.952, p-value=0.001), marital status (married; X2-test=12.399, p-value=0.002), and income (<5,000 baht; X2-test=27.757, p-value=0.015) were significantly associated with raw fish consumption. This result indicates that the population had risk consumption for liver fluke infection particularly of various cyprinoid fishes that are 2nd intermediate hosts. Therefore, health education is required to improve their behavior.https://journal.waocp.org/article_16303_ce4c6d5b4959200918bffa3671e8d4cd.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Microglial Contribution to Glioma Progression: an Immunohistochemical Study in Eastern India2767277316306APJCP.2016.17.6.2767ENKrishnenduGhoshImmunobiology Lab, Department of Zoology, Panihati Mahavidyalaya, Barasat Road, Sodepur, Kolkata, West Bengal, IndiaAnirbanKrishnenduGhoshImmunobiology Lab, Department of Zoology, Panihati Mahavidyalaya, Sodepur, Kolkata, West Bengal, IndiaSamarendranathGhoshDepartment of Neurosurgery, Bangur Institute of Neurosciences, Kolkata, West Bengal, IndiaUttaraChatterjeeDepartment of Pathology, SSKM Hospital, IPGME&R, Kolkata, West Bengal, IndiaSwapnaChaudhuriDepartment of Experimental Medicine, School of Tropical
Medicine, Kolkata, West Bengal, IndiaAnirbanGhoshImmunobiology Lab, Department of Zoology, Panihati Mahavidyalaya, Sodepur, Kolkata, West Bengal, IndiaJournal Article19700101Human glioma, arising from glial cells of the central nervous system, accounts for almost 30%of all brain tumours , neoplasms with a poor prognosis and high mortality rates worldwide. In the present study we assessed tissue architectural modifications associated with macrophage lineage cells, controversial major immune effector cells within the brain, in human glioma tissue samples from eastern India. Ethically cleared post-operative human glioma samples from our collaborative neurosurgery unit with respective CT/MRI and patient history were collected from the Nodal Centre of Neurosciences in Kolkata, over 9 months. Along with conventional histopathology, samples were subjected to silver-gold staining and fluorescence tagged immunophenotyping for the detection of electron dense brain macrophage/microglia cells in glioma tissue, followed by immune-phenotyping of cells. With higher grades, CD11b+/Iba-1+ macrophage/microglia architecture with de-structured boundaries of glioma lesions indicated malfunction and invasive effector state. Present study documented a contribution of microglia to glioma progression in Eastern India.https://journal.waocp.org/article_16306_e2d7eac47a3502c344b0143d6f0ded67.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Diagnostic Performance of Whole-Body Diffusion-Weighted Imaging Compared to PET-CT Plus Brain MRI in Staging Clinically Resectable Lung Cancer2775278016311APJCP.2016.17.6.2775ENKatsuoUsudaDepartment of Thoracic Surgery, Kanazawa Medical University, Ishikawa, JapanTakuma Matsui MunetakaMatobaKatsuoUsudaDepartment of Thoracic Surgery, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanMotoyasuSagawaDepartment of Thoracic Surgery, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanSumikoMaedaDepartment of Thoracic Surgery, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanNozomuMotonoDepartment of Thoracic Surgery, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanMakotoTanakaDepartment of Thoracic Surgery, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanYuichiroMachidaDepartment of Thoracic Surgery, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanTakuma MatsuiMunetaka MatobaDepartment of Radiology,Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanNaotoWatanabeDepartment of Radiology,Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanHisaoTonamiDepartment of Radiology,Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanYoshimichiUedaDepartment of Pathophysiological and Experimental Pathology,
Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanHidetakaUramotoDepartment of Thoracic Surgery, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, JapanJournal Article19700101<span style="text-decoration: underline;">Background</span>: Precise staging of lung cancer is usually evaluated by PET-CT and brain MRI. Recently, however, whole-body diffusion-weighted magnetic resonance imaging (WB-DWI) has be applied. The aim of this study is to determine whether the diagnostic performance of lung cancer staging by WB-DWI is superior to that of PET-CT+brain MRI.
<span style="text-decoration: underline;">Materials and Methods</span>: PET-CT + brain MRI and WB-DWI were used for lung cancer staging before surgery with 59 adenocarcinomas, 16 squamous cell carcinomas and 6 other carcinomas.
<span style="text-decoration: underline;">Results</span>: PET-CT + brain MRI correctly identified the pathologic N staging in 67 patients (82.7%), with overstaging in 5 (6.2%) and understaging in 9 (11.1%), giving a staging accuracy of 0.827. WB-DWI correctly identified the pathologic N staging in 72 patients (88.9%), with overstaging in 1 (1.2%) and understaging in 8 patients (9.9%), giving a staging accuracy of 0.889. There were no significant differences in accuracies. PET-CT + brain MRI correctly identified the pathologic stages in 56 patients (69.1%), with overstaging in 7 (8.6%) and understaging in 18 (22.2%), giving a staging accuracy of 0.691. WB-DWI correctly identified the pathologic stages in 61 patients (75.3%), with overstaging in 4 (4.9%) and understagings in16(19.7%), giving a staging accuracy of 0.753. There were no significant difference in accuracies.
<span style="text-decoration: underline;">Conclusions</span>: Diagnostic efficacy of WB-DWI for lung cancer staging is equivalent to that of PET-CT + brain MRI.https://journal.waocp.org/article_16311_0377e1b8a0132e1a5d7d8324a016f8a2.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma2781278516313APJCP.2016.17.6.2781ENMaryamSedighiDivision of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, IranSeyed AmirAledavoodMaryamSedighiDivision of Human Genetics, Immunology Research Center, Avicenna Research Institute,
Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.Seyed AmirAledavoodDepartment of Radiotherapy and
Oncology, Omid Hospital, Mashhad University of Medical Sciences,Mashhad, IranMRAbbaszadeganDivision of Human Genetics, Immunology Research Center, Avicenna Research Institute,
Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.BahramMemarDepartment of Pathology, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.MehdiMontazerDepartment of Pathology, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.MajidRajabianHerbal biochemistry Department
,payamnoor university- Faculty of basic science- Biology Group, Tehran, Iran.MehranGholaminDivision of Human Genetics, Immunology Research Center, Avicenna Research Institute,
Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Matric metalloproteinase (MMP) 13 gene expression is increased in esophageal squamous cell carcinomas (ESCCs) and associated with increasing tumor invasion, lymph node involvement and decreased survival rates. Levels of the circulating enzyme may be elevated and used as a marker of tumor progression. In this study, clinical application of MMP-13 serum levels was evaluated for early detection, prediction of prognosis and survival time of ESCC patients.
<span style="text-decoration: underline;">Materials and Methods</span>: Serum levels of MMP13 were determined by ELISA in 66 ESCC patients prior of any treatment and 54 healthy controls for comparison with clinicopathological data through statistical analysis with Man Whitney U and Log-Rank tests. In addition, clinical value of MMP13 levels for diagnosis was evaluated by receiver operating characteristic (ROC) test.
<span style="text-decoration: underline;">Results</span>: The serum level of MMP-13 in patients (>250 pg/ml) was significantly higher than in the control group (Conclusions: These findings indicate a potential clinical significance of serum MMP13 measurement for early detection and prognostic assessment in ESCC patients.https://journal.waocp.org/article_16313_89b83dc7f2b616085749fce22cde83de.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Oncogenic Activation of Fibroblast Growth Factor Receptor-3 and RAS Genes as Non-Overlapping Mutual Exclusive Events in Urinary Bladder Cancer2787279316314APJCP.2016.17.6.2787ENArshad APandithAdvanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, IndiaArshadPandithAdvanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, J& K, India.AashaqHussainDepartment of Urology,Sher-I-Kashmir Institute of Medical Sciences, Srinagar, J& K, India.Mosin SKhanDepartments of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, J& K, India.Zafar AShahDepartments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, J& K, India.M SaleemWaniDepartments of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, J& K, India.MushtaqSiddiqiDepartments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, J& K, India.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Urinary bladder cancer is a common malignancy in the West and ranks as the 7th most common cancer in our region of Kashmir, India. <em>FGFR3 </em>mutations are frequent in superficial urothelial carcinoma (UC) differing from the <em>RAS </em>gene mutational pattern. The aim of this study was to analyze the frequency and association of <em>FGFR3 </em>and <em>RAS </em>gene mutations in UC cases.
<span style="text-decoration: underline;">Materials and Methods</span>: Paired tumor and adjacent normal tissue specimens of 65 consecutive UC patients were examined. DNA preparations were evaluated for the occurrence of <em>FGFR3 </em>and <em>RAS </em>gene mutations by PCR-SCCP and DNA sequencing.
<span style="text-decoration: underline;">Results</span>: Somatic point mutations of <em>FGFR3 </em>were identified in 32.3% (21 of 65). The pattern and distribution were significantly associated with low grade/stage (p<0.05). The overall mutations in exon 1 and 2 in all the forms of <em>RAS </em>genes aggregated to 21.5% and showed no association with any clinic-pathological parameters. In total, 53.8% (35 of 65) of the tumors studied had mutations in either a <em>RAS </em>or <em>FGFR3 </em>gene, but these were totally mutually exclusive in and none of the samples showed both the mutational events in mutually exclusive <em>RAS </em>and <em>FGFR3</em>.
<span style="text-decoration: underline;">Conclusions</span>: We conclude that <em>RAS </em>and <em>FGFR3 </em>mutations in UC are mutually exclusive and non-overlapping events which reflect activation of oncogenic pathways through different elements.https://journal.waocp.org/article_16314_cf82507cb1e15349ff19a8f6dc9cd10b.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Histomorphology and Immunohistochemistry of Gastrointestinal Stromal Tumors in a Malaysian Population2795279916315APJCP.2016.17.6.2795ENPurushothamKkrishnappaPathology, Medicine, International Medical University, Bukit Jalil, MalaysiaPurushothamKkrishnappaPathology, Medicine, International Medical University,Bukit Jalil, Malaysia.EuLohPathology, Medicine, International Medical University, Kuala Lumpur, Malaysia.Ibtisam BintiMohamadDepartment of Pathology, Hospital Tuanku Ja’afar, Seremban, Malaysia.Mahadevan DevaTataDepartment of Surgery, Hospital Tuanku Ja’afar, Seremban, Malaysia.MeenakshiAkhileshPathology, Medicine, International Medical University, Kuala Lumpur, Malaysia.KandasamiPalayanDepartment of Surgery, Hospital Tuanku Ja’afar, Seremban, Malaysia.Journal Article19700101<span style="text-decoration: underline;">Purpose</span>: To study histomorphological and immunohistochemical patterns of gastro-intestinal stromal tumours (GISTs) in Malaysia.
<span style="text-decoration: underline;">Materials and Methods</span>: A total of 29 GIST cases from Hospital Tuanku Ja’afar, Seremban ,were studied retrospectively over a period of 10 years from January 2002 to December 2011. Patient demographic data like age, sex and etnicity were collected. Tumour characteristics like site, maximum dimension and specimen type were analysed. Evaluation was according to established criteria into very low, low, intermediate and high-risk categories. Immunohistochemical characteristics were also analysed.
<span style="text-decoration: underline;">Results</span>: The mean age of patients was 59.7 years. Males (59%) were found to be more commonly affected than females (41%). The Chinese (45%) were commonly affected than Malays (41%), and Indians (10%). The most common symptom was pain in the abdomen (13.8%). More than half of the cases were seen in stomach (53%). The tumour size ranged from 1.5 cm to 17 cm with a mean of 6.94cm. Microscopic findings revealed that the spindle cell type was the most common (76%). It was observed that the majority of the cases (48%) were categorised in the intermediate risk group. Immunohistochemical staining showed positivity for CD117 (78.6%), CD34 (71.4%), vimentin (86.2%), S-100 (27.6%), SMA (35.7%), PKC THETA (46.4%) and PDGRFA (67.9%).https://journal.waocp.org/article_16315_c9387ceca3c587859a0b6967d201aae7.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701High Occurrence of Non-Clear Cell Renal Cell Carcinoma in Oman2801280416316APJCP.2016.17.6.2801ENAjitVenniyoorDepartment of Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, Sultanate of OmanAjitVenniyoorDepartment of Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, Sultanate of Oman.AbdulEssamDepartment of Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, Sultanate of Oman.FatmaRamadhanDepartment of Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, Sultanate of Oman.HeeranandKeswaniDepartment of Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, Sultanate of Oman.ItratMehdiDepartment of Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, Sultanate of Oman.Bassim AlBahraniDepartment of Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, Sultanate of Oman.Journal Article19700101It is conventionally accepted that renal cell carcinoma (RCC) occurs in older patients and the clear cell type is the most common histology. However, ethnic variations exist and this study was carried out to determine the epidemiological pattern of RCC in Oman. Ninety RCC patients who presented to a tertiary care center in the Sultanate of Oman from 2010 to 2014 were studied. The main findings were that the median age of presentation was low, more patients presented with localized stage, and there was a higher incidence of non-clear (especially papillary) histology. Data from other Gulf countries and possible reasons for the different profile are discussed.https://journal.waocp.org/article_16316_d0351864746c3a32a493c39d274448df.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Clinical Prognostic Score for Predicting Disease Remission with Differentiated Thyroid Cancers2805281016317APJCP.2016.17.6.2805ENCharoonsakSomboonpornDepartment of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCharoonsakSomboonpornDepartment of Radiology,Faculty of Medicine, Khon Kaen University, Khon
Kaen,Thailand.AmpicaMangklabruksDepartment of Internal Medicine, Faculty of Medicine,Chiang Mai University, Chiang Mai, Thailand.The Research Institute for Health Sciences, Chiang Mai University,
Chiang Mai, Thailand.AmmarinThakkinstianSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.PatravootVatanasaptDepartment of OtorhinolaryngologyFaculty of Medicine, Khon Kaen University, Khon
Kaen, Thailand.Cancer Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.SuwanneeNakaphunNuclear Medicine Division, Maharat Nakhon Ratchasima Hospital, Maharat Nakhon Ratchasima, Thailand.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Differentiated thyroid cancer is the most common endocrine malignancy with a generally good prognosis. Knowing long-term outcomes of each patient helps management planning. The study was conducted to develop and validate a clinical prognostic score for predicting disease remission in patients with differentiated thyroid cancer based on patient, tumor and treatment factors.
<span style="text-decoration: underline;">Materials and Methods</span>: A retrospective cohort study of 1,217 differentiated thyroid cancer patients from two tertiary-care hospitals in the Northeast of Thailand was performed. Associations between potential clinical prognostic factors and remission were tested by Cox proportional-hazards analysis in 852 patients (development cohort). The prediction score was created by summation of score points weighted from regression coefficients of independent prognostic factors. Risks of disease remission were estimated and the derived score was then validated in the remaining 365 patients (validation cohort).
<span style="text-decoration: underline;">Results</span>: During the median follow-up time of 58 months, 648 (76.1%) patients in the development cohort had disease remission. Five independent prognostic factors were identified with corresponding score points: duration from thyroid surgery to 131I treatment (0.721), distant metastasis at initial diagnosis (0.801), postoperative serum thyroglobulin level (0.535), anti-thyroglobulin antibodies positivity (0.546), and adequacy of serum TSH suppression (0.293). The total risk score for each patient was calculated and three categories of remission probability were proposed: ≤1.628 points (low risk, 83% remission), 1.629-1.816 points (intermediate risk, 87% remission), and ≥1.817 points (high risk, 93% remission). The concordance (C-index) was 0.761 (95% CI 0.754-0.767).
<span style="text-decoration: underline;">Conclusions</span>: The clinical prognostic scoring model developed to quantify the probability of disease remission can serve as a useful tool in personalized decision making regarding treatment in differentiated thyroid cancer patients.https://journal.waocp.org/article_16317_4aee49d7c97e311cc164e2a4700b9afa.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Polymorphisms of XRCC1 and XRCC2 DNA Repair Genes and Interaction with Environmental Factors Influence the Risk of Nasopharyngeal Carcinoma in Northeast India2811281916318APJCP.2016.17.6.2811ENSeram AnilSinghDepartment of Biotechnology, Assam University Silchar, Pin, Assam, IndiaSankar KumarGhoshDepartment of Biotechnology, Assam University Silchar, Pin, Assam, IndiaJournal Article19700101Multiple genetic and environmental factors have been reported to play key role in the development of nasopharyngeal carcinoma (NPC). Here, we investigated interactions of <em>XRCC1 </em>Arg399Gln and <em>XRCC2 </em>Arg188His polymorphisms and environmental factors in modulating susceptibility to NPC in Northeast India. One-hundred NPC patients, 90 first-degree relatives of patients and 120 controls were enrolled in the study. <em>XRCC1 </em>Arg399Gln and <em>XRCC2 </em>Arg188His polymorphisms were determined using PCR-RFLP, and the results were confirmed by DNA sequencing. Logistic regression (LR) and multifactor dimensionality reduction (MDR) approaches were applied for statistical analysis. The <em>XRCC1 </em>Gln/Gln genotype showed increased risk (OR=2.76; P<0.024) of NPC. However, individuals with both <em>XRCC1 </em>and <em>XRCC2 </em>polymorphic variants had 3.2 fold elevated risk (P<0.041). An enhanced risk of NPC was also observed in smoked meat (OR=4.07; P=0.004) and fermented fish consumers (OR=4.34, P=0.001), and tobacco-betel quid chewers (OR=7.00; P=0.0001) carrying <em>XRCC1 </em>polymorphic variants. However, smokers carrying defective <em>XRCC1 </em>gene showed the highest risk (OR = 7.47; P<0.0001). On MDR analysis, the best model for NPC risk was the five-factor model combination of <em>XRCC1 </em>variant genotype, fermented fish, smoked meat, smoking and chewing (CVC=10/10; TBA=0.636; P<0.0001); whereas in interaction entropy graphs, smoked meat and tobacco chewing showed synergistic interactions with <em>XRCC1</em>. These findings suggest that interaction of genetic and environmental factors might increase susceptibility to NPC in Northeast Indian populations.https://journal.waocp.org/article_16318_e02f7b77fca8c9a97d121f4dc263c2f0.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Polymorphisms of XRCC1 and XRCC2 DNA Repair genes and Interaction with Environmental Factors Influence the Risk of Nasopharyngeal Carcinoma in Northeast India2811281923627ENSeram AnilSinghDepartment of Biotechnology, Assam University Silchar, Pin, Assam, IndiaSankar KumarGhoshJournal Article19700101Multiple genetic and environmental factors have been reported to play key role in the development of nasopharyngeal carcinoma (NPC). Here, we investigated interactions of XRCC1 Arg399Gln and XRCC2 Arg188His polymorphisms and environmental factors in modulating susceptibility to NPC in Northeast India. One-hundred NPC patients, 90 first-degree relatives of patients and 120 controls were enrolled in the study. XRCC1 Arg399Gln and XRCC2 Arg188His polymorphisms were determined using PCR-RFLP, and the results were confirmed by DNA sequencing. Logistic regression (LR) and multifactor dimensionality reduction (MDR) approaches were applied for statistical analysis. The XRCC1 Gln/Gln genotype showed increased risk (OR2.76; <0.024) of NPC. However, individuals with both XRCC1 and XRCC2 polymorphic variants had 3.2 fold elevated risk (<0.041). An enhanced risk of NPC was also observed in smoked meat (OR4.07; P0.004) and fermented fish consumers (OR4.34, P0.001), and tobacco-betel quid chewers (OR7.00; P0.0001) carrying XRCC1 polymorphic variants. However, smokers carrying defective XRCC1 gene showed the highest risk (OR 7.47; <0.0001). On MDR analysis, the best model for NPC risk was the five-factor model combination of XRCC1 variant genotype, fermented fish, smoked meat, smoking and chewing (CVC10/10; TBA0.636; <0.0001); whereas in interaction entropy graphs, smoked meat and tobacco chewing showed synergistic interactions with XRCC1. These findings suggest that interaction of genetic and environmental factors might increase susceptibility to NPC in Northeast Indian populations.West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Adoption and Implementation of Tobacco Control Policies in Schools in India: Results of the Bihar School Teachers Study2821282616319APJCP.2016.17.6.2821ENNMathurHealis Sekhsaria Institute for Public Health, Navi Mumbai, IndiaNMathurHealis Sekhsaria Institute for Public Health, Navi Mumbai, Patna, IndiaMSPednekarHealis Sekhsaria Institute for Public Health, Navi Mumbai, Patna, IndiaGSSorensenCenter for Community-Based Research, Dana Farber Cancer Institute; and Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, Massachusetts, USAEMNaglerCenter for Community-Based Research, Dana Farber Cancer Institute; and Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, Massachusetts, USAAMStoddardNew England Research Institutes, Watertown, MA, USAHALandoDivision of Epidemiology and Community
Health, University of Minnesota, Minneapolis, USAMBAghiHealis Sekhsaria Institute for Public Health, Navi Mumbai, Patna, IndiaDNSinhaSchool of Preventive Oncology, Patna, IndiaPCGuptaHealis Sekhsaria Institute for Public Health, Navi Mumbai, Patna, IndiaJournal Article19700101Implementation of no tobacco policies in schools is associated with lower tobacco use among teachers and students. In this study we assessed the extent that a school-based intervention for teachers resulted in adoption and implementation of tobacco control policies. From a random sample of government schools (8th-10th), 72 were randomized into intervention and control conditions. Intervention included health education programs for teachers and support for tobacco control policy implementation. Adoption and implementation of policies were assessed at baseline and immediately after intervention. All 36 intervention and one control school adopted a tobacco-control policy. Higher enforcement of tobacco-control policy was at post intervention (OR=3.26; CI: 2.35, 4.54) compared to baseline in intervention schools. Some 64% of intervention and 28% control schools showed “improvement” in policy implementation. Adoption and implementation of no tobacco policies was positively impacted by intervention. This study provides support for scaling up of school-based tobacco control interventions to promote school tobacco control policies.https://journal.waocp.org/article_16319_9af473338c545d6adc835357380f1c7f.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Mortality Attributable to Second Hand Smoking in Morocco: 2012 Results of a National Prevalence Based Study2827283216320APJCP.2016.17.6.2827ENNabilTachfoutiLaboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy, University Sidi Mohammed ben Abdallah Fez MoroccoNabilTachfoutiLaboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy. University Sidi
Mohammed ben Abdallah, TangierAdilNajdiFaculty of Medicine and Pharmacy, University Abdelmalek Saadi, TangierBadiaaLyoussiLaboratory of Physiology- Pharmacology-Environmental Health, Faculty of Sciences Dhar Mahraz,
Fez,TangierChakibNejjariUniversity Mohammed VI of Health Sciences
Casablanca, MoroccoJournal Article19700101<span style="text-decoration: underline;">Purpose</span>: To estimate the number of deaths attributable to second hand smoking (SHS) in Morocco in 2012.
<span style="text-decoration: underline;">Materials and Methods</span>: prevalence based study focusing on mortality from ischaemic heart disease (IHD) and lung cancer among non-smokers aged 35 and over. Prevalence of SHS among never smokers was gathered from a national cross sectional survey on tobacco and population attributable risk (PAR) was calculated by applying PARs to mortality. The analyses were stratified by sex, age and area of exposure.
<span style="text-decoration: underline;">Results</span>: Rates for exposure to SHS among men aged 35-64 years ranged from 20.0% at home to 57.4% at work. Among non-smoking Moroccans aged 35 and over, 233 (IC: 147 - 246) deaths were attributable to exposure to SHS; 156 (IC: 100 - 221) in women and 77 (IC: 44 -125) in men. A total of 173 (122 - 222) deaths were estimated to have been caused by exposure only at home, 34 (9 - 76) by exposure only at the work place and 26 (15 - 58) by exposure both at home and work places. Exposure to SHS could be responsible for 182 (128 - 237) deaths from IHD and 51 (19 - 109) from lung cancer.
<span style="text-decoration: underline;">Conclusions</span>: These data confirm that SHS needs urgent attention in Morocco.https://journal.waocp.org/article_16320_acee629e6dc98edf94457f37aa1483ce.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Risk Perception and Correlates of Tobacco Use among Young People Outside of Formal School Settings in Lagos State, Nigeria2833283916321APJCP.2016.17.6.2833ENOOOdukoyaDepartment of Community Health and Primary Care, College of Medicine, University of Lagos, Idi-Araba, Lagos State, NigeriaDepartment of Community Health, Lagos University Teaching Hospital, Idi-Araba, Lagos state, NigeriaMRDadaDepartment of Community Health and Primary Care, College of Medicine, University of Lagos, Idi-Araba, Lagos State, NigeriaTOlubodunDepartment of Community Health, Lagos University Teaching Hospital, Idi-Araba, Lagos state, NigeriaUIgwiloDepartment of Community Health, Lagos University Teaching Hospital, Idi-Araba, Lagos state, NigeriaOAAyo-YusufSefako Makgatho Health Sciences University, Limpopo, South AfricaJournal Article19700101<span style="text-decoration: underline;">Background</span>: Tobacco use among youth is a major public health problem. Youth outside of formal school settings are often understudied but may be at increased risk. <span style="text-decoration: underline;">Materials and Methods</span>: A descriptive cross-sectional study was carried out among 326 young people aged 15-24 years in four randomly selected motor parks in Lagos state. Interviewer-administered questionnaires were used to collect data. <span style="text-decoration: underline;">Results</span>: The mean age of the respondents was 21.0±2.3yrs. Many 252 (77.3%) dropped out before the end of the third year of secondary schooling. The majority were aware that active (78.2%), and passive smoking (77.3%) are harmful to health. Nearly two-thirds of the respondents disagreed with an outright ban of cigarettes (63.2%) and restriction of cigarette sales to persons below 18 years (67.9%) while 254 (66.8%) supported a ban on tobacco smoking in enclosed public places. One hundred and fifty (46.0%) respondents had experimented with smoking of which 106 (32.5%) had progressed to become current smokers. Half of the current smokers, 54 (50.9%), felt the need for a cigarette first thing in the morning. A multivariate analysis for smoking initiation, showed that for every increasing year of age, respondents were 1.08 times more likely to have initiated cigarette smoking; males and respondents who lived alone or with peers were 2.34 times and 1.77 times more likely to have initiated smoking respectively; those who consume alcohol and marijuana were 7.27 and 1.89 times respectively more likely to have initiated smoking while those who consumed alcohol were 6.17 times more likely to be current smokershttps://journal.waocp.org/article_16321_bd262a2b62cc594de06975dc4d889184.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Evaluation of Delhi Population Based Cancer Registry and Trends of Tobacco Related Cancers2841284616322APJCP.2016.17.6.2841ENRajeshYadavNational Centre for Disease Control, New Delhi, IndiaRajeshYadavNational Centre for Disease Control, World Health Organization, All India Institute of Medical Sciences, New DelhiRenuGargRegional Office for South-East Asia, World Health Organization, All India Institute of Medical Sciences, New DelhiNManoharanDelhi Cancer Registry,
All India Institute of Medical Sciences, New DelhiLSwasticharanNational Tobacco Control
Programme, Directorate General of Health Services, Ministry of Health and Family Welfare, New DelhiPKJulkaDelhi Cancer Registry,
All India Institute of Medical Sciences, New DelhiGKRathDirectors Office, B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New DelhiJournal Article19700101<span style="text-decoration: underline;">Background</span>: Tobacco use is the single most important preventable risk factor for cancer. Surveillance of tobacco-related cancers (TRC) is critical for monitoring trends and evaluating tobacco control programmes. We analysed the trends of TRC and evaluated the population-based cancer registry (PBCR) in Delhi for simplicity, comparability, validity, timeliness and representativeness.
<span style="text-decoration: underline;">Materials and Methods</span>: We interviewed key informants, observed registry processes and analysed the PBCR dataset for the period 1988-2009 using the 2009 TRC definition of the International Agency for Research on Cancer. We calculated the percentages of morphologically verified cancers, death certificate-only (DCO) cases, missing values of key variables and the time between cancer diagnosis and registration or publication for the year 2009.
<span style="text-decoration: underline;">Results</span>: The number of new cancer cases increased from 5,854 to 15,244 (160%) during 1988-2009. TRC constituted 58% of all cancers among men and 47% among women in 2009. The age-adjusted incidence rates of TRC per 100,000 population increased from 64.2 to 97.3 among men, and from 66.2 to 69.2 among women during 1988-2009. Data on all cancer cases presenting at all major government and private health facilities are actively collected by the PBCR staff using standard paper-based forms. Data abstraction and coding is conducted manually following ICD-10 classifications. Eighty per cent of cases were morphologically verified and 1% were identified by death certificate only. Less than 1% of key variables had missing values. The median time to registration and publishing was 13 and 32 months, respectively.
<span style="text-decoration: underline;">Conclusions</span>: The burden of TRC in Delhi is high and increasing. The Delhi PBCR is well organized and generates high-quality, representative data. However, data could be published earlier if p aper-based data are replaced by electronic data abstraction.<strong>.</strong>https://journal.waocp.org/article_16322_3e70e523e5d178d513e596c0646bdc66.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Past Trends and Future Estimation of Annual Breast Cancer Incidence in Osaka, Japan2847285216323APJCP.2016.17.6.2847ENYasuhiroToyodaDepartment of Surgery, Saiseikai Senri Hospital, Suita-shi, Osaka, JapanYasuhiroToyodaDepartment of Surgery, Saiseikai Senri Hospital, Suita, JapanDepartment of Cancer Control and Statistics, Osaka Medical Center for
Cancer and Cardiovascular Diseases, Osaka, JapanTakahiroTabuchiDepartment of Cancer Control and Statistics, Osaka Medical Center for
Cancer and Cardiovascular Diseases, Osaka, JapanTomioNakayamaDepartment of Cancer Control and Statistics, Osaka Medical Center for
Cancer and Cardiovascular Diseases, Osaka, JapanShigeyukiHojoDepartment of Surgery, Saiseikai Senri Hospital, Suita, JapanSetsukoYoshiokaDepartment of Surgery, Saiseikai Senri Hospital, Suita, JapanYoshiichiMaeuraDepartment of Surgery, Saiseikai Senri Hospital, Suita, JapanJournal Article19700101<span style="text-decoration: underline;">Background</span>: Although the breast cancer incidence rate in Japan is lower than in western countries, the age-specific rates have markedly increased in recent years, along with the problems of declining birth rate and an aging population.
<span style="text-decoration: underline;">Materials and Methods</span>: We examined past trends of age-specific breast cancer incidence using data from the Osaka Cancer Registry from 1976 to 2010, and estimated future trends until 2025 based on the changes observed and population dynamics using a log linear regression model.
<span style="text-decoration: underline;">Results</span>: The age-specific breast cancer incidence rate has increased consistently from the 1970s, and the rates have caught up with those of Japanese-Americans in the US. Assuming the increasing tendency of age-specific breast cancer incidence to be constant, the average annual incidence of breast cancer will increase 1.7-fold from 2006-2010 to 2021-2025. Furthermore, the number of patients aged 80 years should increase 3.4-fold.
<span style="text-decoration: underline;">Conclusions</span>: The medical demand for breast cancer care in Japan may increase explosively in the future, particularly among the elderly. We need to prepare for such a future increase in demand for care, although careful monitoring is needed to confirm these results. https://journal.waocp.org/article_16323_565d4f4842063f7e01c4c6b12bd814e8.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Limited Impact of Music Therapy on Patient Anxiety with the Large Loop Excision of Transformation Zone Procedure - a Randomized Controlled Trial2853285616324APJCP.2016.17.6.2853ENChompunootKongsawatvorakulDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandChompunootKongsawatvorakulDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.ChuenkamonCharakornDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.KrissadaPaiwattananupantDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.NavamolLekskulDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.SasivimolRattanasiriSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.Arb-AroonLertkhachonsukDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Many studies have pointed to strategies to cope with patient anxiety in colposcopy. Evidence shows that patients experienced considerable distress with the large loop excision of transformation zone (LLETZ) procedure and suitable interventions should be introduced to reduce anxiety. This study aimed to investigate the effects of music therapy in patients undergoing LLETZ.
<span style="text-decoration: underline;">Materials and Methods</span>: A randomized controlled trial was conducted with patients undergoing LLETZ performed under local anesthesia in an out patient setting at Ramathibodi Hospital, Bangkok, Thailand, from February 2015 to January 2016. After informed consent and demographic data were obtained, we assessed the anxiety level using State Anxiety Inventory pre and post procedures. Music group patients listened to classical songs through headphones, while the control group received the standard care. Pain score was evaluated with a visual analog scale (VAS). Statistical analysis was conducted using Pearson Chi-square, Fisher’s Exact test and T-Test and p-values less than 0.05 were considered statistically significant.
<span style="text-decoration: underline;">Results</span>: A total of 73 patients were enrolled and randomized, resulting in 36 women in the music group and 37 women in the non-music control group. The preoperative mean anxiety score was higher in the music group (46.8 VS 45.8 points). The postoperative mean anxiety scores in the music and the non-music groups were 38.7 and 41.3 points, respectively. VAS was lower in music group (2.55 VS 3.33). The percent change of anxiety was greater in the music group, although there was no significant difference between two groups.
<span style="text-decoration: underline;">Conclusions</span>: Music therapy did not significantly reduce anxiety in patients undergoing the LLETZ procedure. However, different interventions should be developed to ease the patients’ apprehension during this procedure.https://journal.waocp.org/article_16324_a8729a3be14dc0f24532050e84910956.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701High Prevalence of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection in Thailand2857286016325APJCP.2016.17.6.2857ENNattawatWanichDepartment of Medicine, Thammasat University Hospital, Pathumthani, Thailand0000-0003-4298-9331NattawatWanichDepartment of Medicine, Thammasat University Hospital, Pathumthani, Thailand.Ratha-KornVilaichoneDepartment of Medicine, Thammasat University Hospital, Pathumthani, Thailand.PeranartChotivitayatarakornDepartment of Medicine, Thammasat University Hospital, Pathumthani, Thailand.SithSiramolpiwatDepartment of Medicine, Thammasat University Hospital, Pathumthani, Thailand.Journal Article19700101
<span style="text-decoration: underline;">Background</span>: Chronic hepatitis B (CHB) infection is one of the important causes of hepatocellular carcinoma (HCC) in Thailand, involved in the pathogenesis and leading to a development of HCC with or without cirrhotic changes of the liver. This study was aimed to investigate the predictive factors for HCC among CHB patients in a tertiary care center in Thailand. <span style="text-decoration: underline;">Materials and Methods</span>: We conducted a retrospective study of CHB patients with or without HCC during the period of January 2009 and December 2014 at Thammasat University Hospital, Pathumthani, Thailand. Data on clinical characteristics, biochemical tests and radiologic findings were collected from review of medical records. <span style="text-decoration: underline;">Results</span>: A total of 266 patients were diagnosed with CHB in Thammasat university hospital during the study period. However, clinical information of only 164/266 CHB patients (98 males, 66 females with mean age of 49.4 years) could be completely retrieved in this study. The prevalence of HCC in CHB infection in this study was 38/164 (23.2%). CHB patients with HCC had a mean age older than those without HCC (59.5 vs 47 years, P-value = 0.01). Furthermore, history of upper GI bleeding, tattooing, blood transfusion, and chronic alcoholism were significantly more common in CHB patients with HCC than patients without HCC (13.2% vs 3.2% P-value 0.03, OR = 4.6, 95%CI = 1.2-18.1, 20% vs 3.9%, P-value = 0.01, OR= 6.1, 95% CI= 1.6-23.6, 20% vs 6.3%, P-value = 0.03, OR = 3.8, 95%CI =1.1-12.7, 62.2% vs 30.3%, P-value <0.0001, OR = 3.7, 95%CI= 1.7-8.1 respectively). Interestingly, more CHB patients with HCC had evidence of cirrhosis than those without HCC (78.9% vs 20.4%, P-value <0.0001, OR = 14.6, 95%CI = 5.8-36.7). In CHB patients with HCC, surgical therapy provided longer survival than radiofrequency ablation (RFA) (72 vs 46.5 months, P-value= 0.04). The mean survival time after HCC diagnosis was 17.2 months. <span style="text-decoration: underline;">Conclusions</span>: HCC remains a major problem among patients with CHB infection in Thailand. Possible risk factors are male gender, history of upper GI bleeding, chronic alcoholism, tattooing, blood transfusion and evidence of cirrhosis. For early stage HCC patients, surgical treatment provided longer survival time than RFA. Most HCC patients presented with advanced disease and had a grave prognosis. Appropriate screening of CHB patients at risk for HCC might be an appropriate approach for early detection and improvement of long-term outcomes.https://journal.waocp.org/article_16325_389b5b2f18999c5831b045af69ca28db.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701No Association of Cytochrome P450-1B1 Gene Polymorphisms with Risk of Breast Cancer: an Egyptian Study2861286616326APJCP.2016.17.6.2861ENMona HIbrahimDepartment of Clinical and Chemical Pathology, National Research Center,Cairo University, Cairo, Egypt.RehamRashedDepartment of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.NaglaaHassanDepartment of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.NevinAl-azharyBiochemistry and Molecular
Medicine Department, College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaDepartment of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.Asmaa ISalamaDepartment of Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.Marwa NMostafaDepartment of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.Journal Article19700101It is thought that population characteristics of breast cancer may be due to a variation in the frequency of different alleles of genes such as <em>CYP1B1</em>. We aimed to determine the association of <em>CYP1B1 </em>polymorphisms in 200 breast cancer cases and 40 controls by PCR-RFLP. Frequencies were assessed with clinical and risk factors in Egyptian patients. The genotype LV and the Leu allele frequencies for patients and controls were 42.9% and 50%, and 52.9% and 53.3%, respectively), with no significant differences observed (P values = 0.8 and 0.6, respectively). There was also no significant association between genotypes and any risk factors for cases (P>0.05) except laterality and metastasis of the tumor (P values=0.006 and 0.06, respectively). The <em>CYP1B1 </em>polymorphism Val432Leu was not associated with breast cancer in Egypt, but may provide clues for future studies into early detection of the disease.https://journal.waocp.org/article_16326_3035b2a80bd796cdeb9f10339bffcf66.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701ssociation of Cytochrome P450-1B1 Gene Polymorphisms with Risk of Breast Cancer: an Egyptian Study2861286623628ENMona HIbrahimDepartment of Clinical and Chemical Pathology, National Research Center, Cairo University, Cairo, EgyptReham ARashedNaglaa MHassanNevin MAl-azharyAsmaa ISalamaMarwa NMostafaJournal Article19700101It is thought that population characteristics of breast cancer may be due to a variation in the frequency of different alleles of genes such as CYP1B1. We aimed to determine the association of CYP1B1 polymorphisms in 200 breast cancer cases and 40 controls by PCR-RFLP. Frequencies were assessed with clinical and risk factors in Egyptian patients. The genotype LV and the Leu allele frequencies for patients and controls were 42.9% and 50%, and 52.9% and 53.3%, respectively), with no significant differences observed (P values 0.8 and 0.6, respectively). There was also no significant association between genotypes and any risk factors for cases (>0.05) except laterality and metastasis of the tumor (P values0.006 and 0.06, respectively). The CYP1B1 polymorphism Val432Leu was not associated with breast cancer in Egypt, but may provide clues for future studies into early detection of the disease.West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Endometrial Cancer in Hospital Universiti Sains Malaysia2867287016327APJCP.2016.17.6.2867ENWan AdnanWan-Nor-AsyikeenUnit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia0000-0002-8212-9849Nur Asyilla CheJalilAnani Aila MatZainWan AdnanWan-Nor-AsyikeenUnit of Biostatistics and Research Methodology,School of Medical Sciences, Universiti Sains Malaysia,
Kubang Kerian, Kelantan, Malaysia.AbSiti-AzrinUnit of Biostatistics and Research Methodology,School of Medical Sciences, Universiti Sains Malaysia,
Kubang Kerian, Kelantan, Malaysia.NurChe JalilDepartment of Pathology, School of Medical Sciences, Universiti Sains Malaysia,Kubang Kerian, Kelantan, Malaysia.NorOthmanDepartment of Pathology, School of Medical Sciences, Universiti Sains Malaysia,Kubang Kerian, Kelantan, Malaysia.AnaniMat ZainDepartment of Pathology, School of Medical Sciences, Universiti Sains Malaysia,Kubang Kerian, Kelantan, Malaysia.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Endometrial cancer is the most common gynecological malignancy among females worldwide, approximately 320,000 women being diagnosed with the disease each year and 76,000 dying. To date, there is limited knowledge of endometrial cancer in Malaysia.
<span style="text-decoration: underline;">Objectives</span>: To identify the epidemiological profile and prognostic factors of survival.
<span style="text-decoration: underline;">Materials and Methods</span>: A list of endometrial cancer patients in 2000-2011 was obtained from the hospital Record Department. Only cases confirmed by histopathology examination were included. We excluded those with incomplete medical records or referral cases. Simple and multiple Cox regression approaches were used for data analysis.
<span style="text-decoration: underline;">Results</span>: Only 108 cases were included with a mean (SD) age of 62.7 (12.3) years, with 87.0% Malay ethnicity. Grade of cancer was: 29.1% grade 1, 43.7% grade 2 and 27.2% grade 3. The majority of patients had non-endometrioid type (60.2%), with myometrial invasion (82.2%) and lymphovascular invasion (57.3%). The significant prognostic factors were age (HR 1.05; 95% CI: 1.02, 1.08, p=0.002) and having lymphovascular invasion (HR 2.15; 95% CI: 1.08, 4.29; p=0.030).
<span style="text-decoration: underline;">Conclusions</span>: Endometrial cancer patients should be diagnosed earlier to reduce the risk of mortality. The public should be given education on the signs and symptoms of the disease.https://journal.waocp.org/article_16327_4bb7a6c661372ee5db7acf011f56fdcf.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Effects of Group Training Based on the Health Belief Model on Knowledge and Behavior Regarding the Pap Smear Test in Iranian Women: a Quasi-Experimental Study2871287616328APJCP.2016.17.6.2871ENFatemehShobeiriMother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, IranFatemehShobeiriMother and Child Care Research Center,School of Public Health, Hamadan University of Medical
Sciences, Hamadan, IR Iran.MasoumehJavadM.Sc. of Counseling in Midwifery, Student Research Center, School of Nursing and Midwifery,Hamadan University of Medical Sciences, Hamadan, IR Iran.ParisaParsaChronic Disease Research Center,School of Public Health, Hamadan University of Medical
Sciences, Hamadan, IR Iran.GhodratollahRoshanaeiDepartment of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, IR Iran.Journal Article19700101The Pap smear test is recommended for early diagnosis of cervical cancer. The aim of this study was to assess knowledge and behavior regarding the Pap smear test based on the Health Belief Model (HBM) in women referred to premarital counseling classes, Hamadan, Iran. This quasi-experimental study was conducted on 330 women, who were allocated randomly to two case and control groups (n=165). Two educational session classes were performed in the case group. Two stages in before and after intervention groups were evaluated. Analysis of data was performed by SPSS/16.0, using t-test, x2, and McNemar’s test. P-valueshttps://journal.waocp.org/article_16328_771870dffce5e6de9c0f02d8aa102e9e.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Risk Factors for Lung Cancer Mortality in a Referral Center2877288116329APJCP.2016.17.6.2877ENHJamaatiChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IranHJamaatiChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranPBaghaeiClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical
Sciences, Tehran, Iran.MSharifianfardChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranHEmamiTobacco Prevention
and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical
Sciences, Tehran, Iran.KNajmiChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSSeifiChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBSalimiChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMPourabdollahChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranAKianiChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMHashemianChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranAKhosraviChronic Respiratory Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranJournal Article19700101<span style="text-decoration: underline;">Background</span>: Lung cancer is one of the most common causes of death that is rising in many countries including Iran. This study aimed to determine the impact of factors on survival of lung cancer patients at a referral center of lung diseases in Tehran, Iran. <span style="text-decoration: underline;">Materials and Methods</span>: A retrospective study was conducted on adult lung cancer cases admitted to a referral center for lung diseases from 2011 to 2015. Multivariate analysis was performed to determine the risk factors for all-cause mortality. <span style="text-decoration: underline;">Results</span>: Of a total 933 patients with lung cancer, 53.4% died, 49.3% of them at the hospital. Overall median follow-up time was 7 months. The most common histological type of cancer was adenocarcinoma with a 13 month median survival time. Age ≥55 and smoking remained significant for all-cause mortality on Cox analysis, whereas gender was not. <span style="text-decoration: underline;">Conclusions</span>: The survival of lung cancer patients is poor and the patients with history of smoking and age≥55 are at increased risk of death. Having a large hospital-based registry provides a good measurement of prognostic statistics for lung cancer. Further investigations are necessary to establish reasons for mortality.https://journal.waocp.org/article_16329_53c46fd3e7f58f1f6594c0ce576352cb.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study2883288816330APJCP.2016.17.6.2883ENNabarunRoyDistributed Information Centre, Kerala Agricultural University, Kerala, IndiaNabarunRoyDistributed Information Centre,Thrissur, Kerala, India.SangeethaDavisDistributed Information Centre,Thrissur, Kerala, India.ArunaksharanNarayanankuttyAmala Cancer Research Centre, Thrissur, Kerala, India.PANazeemDistributed Information Centre,Thrissur, Kerala, India.TDBabuAmala Cancer Research Centre, Thrissur, Kerala, India.PSAbidaCentre for Plant Biotechnology and Molecular Biology, Kerala Agricultural University,Thrissur, Kerala, India.PAValsalaCentre for Plant Biotechnology and Molecular Biology, Kerala Agricultural University,Thrissur, Kerala, India.AchuthanRaghavamenonAmala Cancer Research Centre, Thrissur, Kerala, India.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with anti-cancer potential but selection must be made on the basis of no adverse side effects. This study is focused on finding of compounds from a plant source garlic.
<span style="text-decoration: underline;">Materials and Methods</span>: Twenty compounds from garlic and five targets considered involved in BC were retrieved from Pubchem database and Protein Data Bank respectively. They were docked using Accelrys Discovery Studio (DS) 4.0. The compounds which showed interaction were checked for drug likeliness.
<span style="text-decoration: underline;">Results</span>: Docking studies and ADMET evaluation revealed twelve compounds to be active against the targets. All the compounds displayed highly negative dock scores which indicated good interactions.
<span style="text-decoration: underline;">Conclusions</span>: The results of this study should help researchers and scientists in the pharmaceutical field to identify drugs based on garlic.https://journal.waocp.org/article_16330_8a75fac75c7a997088cd4f55e943ab24.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Behavioral Modification Regarding Liver Fluke and Cholangiocarcinoma with a Health Belief Model Using Integrated Learning2889289416332APJCP.2016.17.6.2889ENPanidaPhatisenaPublic Health Program, Faculty of Public Health, Nakhon Ratchasima Rajabhat University, Nakhon Ratchasima, Thailand0000-0002-2806-2129PanidaPhatisenaPublic Health Program, Faculty of Public Health, Nakhon Ratchasima Rajabhat University,Khon Kaen, Thailand.TawatchaiEaksantiPublic Health Program, Faculty of Public Health, Nakhon Ratchasima Rajabhat University,Khon Kaen, Thailand.PitsaneeWichantukPublic Health Program, Faculty of Public Health, Nakhon Ratchasima Rajabhat University,Khon Kaen, Thailand.JaruwanTritipsombutPublic Health Program, Faculty of Public Health, Nakhon Ratchasima Rajabhat University,Khon Kaen, Thailand.SorayaKaewpitoonParasitic Disease Research
Unit, Suranaree University of Technology, Khon Kaen, Thailand.Suranaree University of Technology Hospital, Khon Kaen, Thailand.School of Family Medicine and Community Medicine Khon Kaen, Thailand.RatanaRujirakulParasitic Disease Research
Unit, Suranaree University of Technology, Khon Kaen, Thailand.ParichartWakkhuwattapongParasitic Disease Research
Unit, Suranaree University of Technology, Khon Kaen, Thailand.TaweesakTongtaweeSuranaree University of Technology Hospital, Khon Kaen, Thailand.School of Surgery, Institute of Medicine, Khon Kaen University, Khon Kaen, Thailand.LikitMatrakoolSuranaree University of Technology Hospital, Khon Kaen, Thailand.School of Surgery, Institute of Medicine, Khon Kaen University, Khon Kaen, Thailand.SukijPanpimanmasSuranaree University of Technology Hospital, Khon Kaen, Thailand.School of Surgery, Institute of Medicine, Khon Kaen University, Khon Kaen, Thailand.JunNorkaewFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen, Thailand.JirawootKujapunFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen, Thailand.WasugreeChavengkunFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen, Thailand.PorntipKomporFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen, Thailand.MaliPothipimFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen, Thailand.SukanyaPonphimaiFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen, Thailand.NatnapaPadchasuwanFaculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.NatthawutKaewpitoonParasitic Disease Research
Unit, Suranaree University of Technology, Khon Kaen, Thailand.Suranaree University of Technology Hospital, Khon Kaen, Thailand.Faculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen, Thailand.Journal Article19700101This study aimed to modify behavior regarding liver fluke and cholangiocarcinoma prevention in Chumphuang district, Nakhon Ratchasima province, Thailand through integrated learning. A total of 180 participants were included through purposive selection of high-risk scores on verbal screening. Participants attended the health education program which applied the health belief model included family based, knowledge station based, academic merit based and community based learning. Data were collected using a questionnaire composed of 4 parts: 1) personal information, 2) knowledge, 3) perceived susceptibility, severity, benefits, and barriers, 4) practice regarding liver fluke and cholangiocarcinoma prevention. The result revealed that the majority were female (79.9%), age ≥ 60 years old (33.2%), primary school educational level (76.1%), and agricultural occupation (70.1%). The mean scores of knowledge, perception, and practice to liver fluke and cholangiocarcinoma prevention, before participated the integrative learning were low, moderate, and low, respectively. Meanwhile, the mean score of knowledge, perceived susceptibility, severity, benefits, and barriers, and practice regarding liver fluke and cholangiocarcinoma prevention, were higher with statistical significance after participation in the integrated learning. This finding indicates that health education programs may successfully modify health behavior in the rural communities. Therefore they may useful for further work behavior modification in other epidemic areas.https://journal.waocp.org/article_16332_2f348e9405a6a0bcac6c37a516fd252d.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Temporal Trends and Future Prediction of Breast Cancer Incidence Across Age Groups in Trivandrum, South India2895289916333APJCP.2016.17.6.2895ENAleyammaMathewDivisions of Cancer Epidemiology and Bio-statistics, Trivandrum, Kerala, IndiaAleyammaMathewDivisions of Cancer Epidemiology & Bio-statistics, Trivandrum, Kerala, India.PreethiGeorgeDivisions of Cancer Epidemiology & Bio-statistics, Trivandrum, Kerala, India.AshaArjunanRadiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.PaulAugustineSurgical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.MCKalavathyDivisions of Cancer Epidemiology & Bio-statistics, Trivandrum, Kerala, India.GPadmakumariDivisions of Cancer Epidemiology & Bio-statistics, Trivandrum, Kerala, India.BeelaMathewRadiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005- 2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum.
<span style="text-decoration: underline;">Materials and Methods</span>: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates.
<span style="text-decoration: underline;">Results</span>: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are 60 years and overall CR is 80 (ASR: 57) for 2019- 20.
<span style="text-decoration: underline;">Conclusions</span>: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.https://journal.waocp.org/article_16333_aa05a4f1e68d4a4a60d9936cac9a2ad2.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701What Do Korean Women Know and Want to Know about Thyroid Cancer? A Qualitative Study2901290716342APJCP.2016.17.6.2901ENBomyeeLeeNational Cancer Control Institute, Goyang-si, Gyeonggi- do, Republic of KoreaBomyeeLeeNational Cancer Control Institute, Seoul, Republic of Korea.JaeParkGraduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggido, Seoul, Republic of Korea.HyeShinNational Cancer Control Institute, Seoul, Republic of Korea.Sang HeeParkGraduate School of Communication, Sogang University, Seoul, Republic of Korea.Eun-BiChoiNational Cancer Control Institute, Seoul, Republic of Korea.JisuYooNational Cancer Control Institute, Seoul, Republic of Korea.Kui SonChoiGraduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggido, Seoul, Republic of Korea.JaeJunNational Cancer Control Institute, Seoul, Republic of Korea.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Despite increasing debate about overdiagnosis and overtreatment of thyroid cancer in Korea, information to guide decisions on whether or not to undergo screening for and treatment of abnormal lesions of the thyroid is lacking. Moreover, studies have yet to outline what lay people know and want to know about thyroid cancer. The primary aim of this study was to explore general awareness of thyroid cancer among Korean women, their sources of information, and their satisfaction with the information they are provided. The secondary aim was to investigate information needs about thyroid cancer.
<span style="text-decoration: underline;">Materials and Methods</span>: A qualitative study using focus group interviews was conducted. Twenty-nine women were divided into four groups: (1) participants who had never undergone thyroid ultrasound screening; (2) those who had undergone screening, (3) those who continued to undergo regular check-ups with ultrasonography for benign nodules of the thyroid; and (4) participants who had undergone surgery for thyroid cancer.
<span style="text-decoration: underline;">Results</span>: A widespread lack of awareness of information on thyroid cancer was noted among participants in groups 1 and 2 who were not well aware of thyroid cancer and generally recognized it as a ‘good cancer’. Surprisingly, instead of doctors and medical personnel, most participants reported obtaining information from acquaintances and media outlets. Moreover, most participants described dissatisfaction with their experience with screening and a lack of explanation on treatment and test results from medical personnel.
<span style="text-decoration: underline;">Conclusions</span>: Women in Korea seek reliable information on thyroid cancer that could help them to better understand the disease and make informed decisions regarding screening and treatment. More effort is needed from medical personnel to communicate the implications of thyroid cancer, screening results, and treatments thereof to lay people.https://journal.waocp.org/article_16342_66f79fafa50f0120345f06c329bd4be0.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Application of Immunophenotyping and Heteroduplex Polymerase Chain Reaction (hPARR) for Diagnosis of Canine Lymphomas2909291616347APJCP.2016.17.6.2909ENSirintraSirivisootDepartment of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok,Thailand.SompornTechangamsuwanDepartment of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok,Thailand.SirikachornTangkawattanaDepartment of Veterinary
Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand.AnudepRungsipipatDepartment of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok,Thailand.Journal Article19700101<span style="text-decoration: underline;">Background</span>: Canine malignant lymphoma is classified into B- or T-cell origin, as in the human case. Due to differences in prognosis, a suitable method needs to be developed for lineage identification.
<span style="text-decoration: underline;">Aims</span>: To determine the accuracy of immunophenotypic and molecular information between three methods: immunocytochemistry (ICC), immunohistochemistry (IHC) and heteroduplex polymerase chain reaction for antigen receptor rearrangements (hPARR) in spontaneous canine lymphomas.
<span style="text-decoration: underline;">Materials and Methods</span>: Peripheral blood, fine needle aspiration and tissue biopsies from enlarged peripheral lymph nodes prior to treatment of 28 multicentric lymphoma patients were collected. Cytopathology and histopathology were examined and classified using the updated Kiel and WHO classifications, respectively. Anti-Pax5 and anti-CD3 antibodies as B- and T-cell markers were applied for immunophenotyping by ICC and IHC. Neoplastic lymphocytes from lymph node and white blood cell pellets from peripheral blood were evaluated by hPARR.
<span style="text-decoration: underline;">Results</span>: In this study, low grade B-cell lymphoma accounted for 25% (7/28), high grade B-cell lymphoma for 64.3% (18/28) and high grade T-cell lymphoma for 10.7% (3/28). According to the WHO classification, 50% of all cases were classified as diffuse large B-cell lymphoma. In addition, ICC showed concordant results with IHC; all B-cell lymphomas showed Pax5+/CD3, and all T-cell lymphomas exhibited Pax5-/CD3+. In contrast to hPARR, 12 B-cell lymphomas featured the IgH gene; seven presented the TCRγ gene; five cases showed both IgH and TCRγ genes, and one case were indeterminate. Three T-cell lymphomas showed the TCRγ gene. The percentage agreement between hPARR and ICC/IHC was 60%.
<span style="text-decoration: underline;">Conclusions</span>: Immunophenotyping should not rely on a single method. ICC or IHC with hPARR should be used concurrently for immunophenotypic diagnosis in canine lymphomas.https://journal.waocp.org/article_16347_d109ee22a39d06214f3065b3ed3b7d2b.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Breast Conserving Therapy and Quality of Life in Thai Females: a Mixed Methods Study2917292116350APJCP.2016.17.6.2917ENThanarpanPeerawongDepartment of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand0000-0003-1725-6355ThanarpanPeerawongDepartment of Radiology, Rajamangala University of Technology Suvarnabhumi, Supanburi, Thailand.TharinPhenwanWalailak University School of Medicine, Nakhon Si Thammarat, Supanburi, Thailand.SojiratSupanitwatthanaFaculty of Liberal Arts, Rajamangala University of Technology Suvarnabhumi, Supanburi, Thailand.SomritMahattanobonDepartment of Surgery, Faculty
of Medicine, Prince of Songkla University, Songkhla,Thailand.ChanonKongkamolResearch Unit of Holistic Health and Safety Management in Community, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.Journal Article19700101<span style="text-decoration: underline;">Background</span>: To explore factors that influence quality of life (QOL) in patients receiving breast conserving therapy (BCT).
<span style="text-decoration: underline;">Materials and Methods</span>: In this sequential mixed methods study, 118 women from Songklanagarind Hospital were included. We used participants’ characteristics, Body Image Scale (BIS), and Functional Assessment of Cancer Therapy with the Breast Cancer Subscale (FACT-B) for analysis. The BIS transformed into presence of body image disturbance (BID). Factors that influenced QOL were determined by stepwise multiple linear regression. Forty-one participants were selected for qualitative analysis. Our female researcher performed the semi-structured interviews with questions based on the symbolic interaction theory. Final codes were analysed using thematic analysis along with investigator triangulation methods.
<span style="text-decoration: underline;">Results</span>: Ninety percent had early stage breast cancer with post-completed BCT, for an average of 2.7 years. The median BIS score and FACT-B score were 2 (IQR=10) and 130 (IQR=39). In the regression analysis, an age of more than 50 years and BID were significant factors. As for the value of conserved breasts, two themes emerged: a conserved breast is an essential part of a participant’s life and also the representation of her womanhood; the importance of a breast is related to age.
<span style="text-decoration: underline;">Conclusions</span>: Body image influenced QOL in post BCT participants. The conserved breasts also lead to positive and better impact on their body image as an essential part of their life.https://journal.waocp.org/article_16350_a3362244679f913812d9ee487b73fdb1.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Mate and Tea Intake, Dietary Antioxidants and Risk of Breast Cancer: a Case-Control Study2923293316351APJCP.2016.17.6.2923ENAlvaro LRoncoUnit of Oncology and Radiotherapy, Pereira Rossell Women's Hospital, Montevideo, UruguayAlvaroVazquezAlvaroRoncoUnit of Oncology and Radiotherapy, Pereira Rossell Women’s Hospital, Montevideo, Uruguay.IUCLAEH School of Medicine,Pereira Rossell Women’s Hospital, Montevideo, Uruguay.Biomedical Sciences Center, University of Montevideo, Uruguay.Eduardo DeStefaniPathology Department,Pereira Rossell Women’s Hospital, Montevideo, Uruguay.BeatrizMendozaEndocrinology and Metabolism Department, Clinical Hospital, UDELAR State University, Montevideo, Uruguay.AlvaroVazquez3Biomedical Sciences Center, University of Montevideo, Uruguay.EstelaAbbonaNutrition Department, Pereira Rossell Women’s Hospital, Montevideo, Uruguay.GustavoSanchezEndocrinology and Metabolism Department, Clinical Hospital, UDELAR State University, Montevideo, Uruguay.AlejandroRosaUnit of Oncology and Radiotherapy, Pereira Rossell Women’s Hospital, Montevideo, Uruguay.Journal Article19700101Recently, we reported an inverse association between high ‘mate’ intake (infusion of <em>Ilex paraguariensis </em>herb, a staple beverage in temperate South America) and breast cancer (BC) risk. Stronger inverse associations were found in high strata of tea, vegetable, fruit and energy intakes, and in overweight/obese women, suggesting possible roles for ‘mate’ mainly from its antioxidant contribution. The present study attempted to thoroughly explore possible associations among ‘mate’ and tea intake, dietary antioxidants and BC risk. Combining two databases of previous studies, 572 BC incident cases and 889 controls were interviewed with a specific questionnaire featuring socio-demographic, reproductive and lifestyle variables, and a food frequency questionnaire (64 items), focusing on ‘mate’ intake (consumer status, daily intake, age at start, age at quit, duration of habit). Food-derived nutrients were calculated from available databases. Odds ratios (OR) and their 95% confidence intervals were calculated through unconditional logistic regression, adjusting for relevant potential confounders. The highest ‘mate’ intake was significantly inversely associated with BC risk for both low and high carotenoids (OR=0.40 <em>vs. </em>0.41), vitamin C (OR=0.33 <em>vs. </em>0.50), vitamin E (OR=0.37 <em>vs. </em>0.45), flavonols (OR=0.38 <em>vs. </em>0.48) and reduced glutathione (OR=0.48 <em>vs. </em>0.46) strata. High tea intake showed significant inverse risk associations only with high carotenoids (OR=0.41), vitamin E (OR=0.48) and reduced glutathione (OR=0.43) strata. In conclusion, a strong and inverse association for ‘mate’ intake and BC was found, independent of dietary antioxidant levels. Also strong inverse associations with tea intake were more evident only at high levels of certain dietary antioxidants.https://journal.waocp.org/article_16351_da8193d567e82ee595f20d9c350f2939.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Association of Estrogen Receptor Alpha and Interleukin 6 Polymorphisms with Lymphovascular Invasion, Extranodal Extension, and Lower Disease-Free Survival in Thai Breast Cancer Patients2935294016352APJCP.2016.17.6.2935ENDoonyapatSa-NguanraksaDivision of Head, Neck and Breast Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDoonyapatSa-NguanraksaDivision of Head, Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.MonthiraSuntiparpluachaDivision of Head, Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.AnchaleeKulpromDivision of Head, Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.TanawanKummalueDepartments of Clinical Pathology, Faculty of Medicine, Siriraj Hospital,
Mahidol University, Bangkok, Thailand.TuenjaiChuangsuwanichDepartments of Pathology,Faculty of Medicine, Siriraj Hospital,
Mahidol University, Bangkok, Thailand.PanissadeeAvirutnanDivision of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine, Siriraj Hospital,
Mahidol University, Bangkok, Thailand.PornchaiO-CharoenratDivision of Head, Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.Journal Article19700101Breast cancer is the most frequent type of cancer diagnosed among women worldwide and also in Thailand. Estrogen and estrogen receptors exert important roles in its genesis and progression. Several cytokines have been reported to be involved in the microenvironment that promotes distant metastasis via modulation of immune and inflammatory responses to tumor cells. Estrogen receptor genetic polymorphisms and several cytokines have been reported to be associated with breast cancer susceptibility and aggressiveness. To investigate roles of genetic polymorphisms in estrogen receptor alpha (<em>ESR1</em>) and interleukin 6 (IL6), breast cancer patients and control subjects were recruited from the Division of Head, Neck and Breast Surgery (Siriraj Hospital, Bangkok, Thailand). Polymorphisms in <em>ESR1 </em>(rs3798577) and IL6 (rs1800795 and rs1800797) were evaluated by real-time PCR in 391 breast cancer patients and 79 healthy controls. Associations between genetic polymorphisms and clinicopathological data were determined. There was no association between genetic polymorphisms and breast cancer susceptibility. However the <em>ESR1 </em>rs3798577 CT genotype was associated with presence of lymphovascular invasion (OR=2.07, 95%CI 1.20-3.56, p=0.009) when compared to the TT genotype. <em>IL6 </em>rs1800795 CC genotype was associated with presence of extranodal extension (OR= 2.30, 95%CI 1.23-4.31, p=0.009) when compared to the GG genotype. Survival analysis showed that <em>IL6 </em>rs1800797 AG or AA genotypes were associated with lower disease-free survival. These findings indicate that polymorphisms in <em>ESR1 </em>and <em>IL6 </em>contribute to aggressiveness of breast cancer and may be used to identify high risk patients.https://journal.waocp.org/article_16352_4fcda5235d7ee9cae8922a1a2850d524.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Head to Head Comparison of the Chun Nomogram, Percentage Free PSA and Primary Circulating Prostate Cells to Predict the Presence of Prostate Cancer at Repeat Biopsy2941294616363APJCP.2016.17.6.2941ENNigel PMurrayHospital Carabineros of Chile, Nunoa, Santiago, Chile0000-0001-8154-8550NigelMurrayHospital Carabineros of Chile, Nunoa, Santiago, Chile.Faculty of Medicine, University Finis Terrae, Providencia Diego Portales University, Manuel Rodrıguez Sur, Santiago, Chile.EduardoReyesHospital Carabineros of Chile, Nunoa, Santiago, Chile.Faculty of Medicine, Diego Portales University, Manuel Rodrıguez Sur, Santiago, Chile.NelsonOrellanaHospital Carabineros of Chile, Nunoa, Santiago, Chile.CynthiaFuentealbaHospital Carabineros of Chile, Nunoa, Santiago, Chile.OmarJacobHospital Carabineros of Chile, Nunoa, Santiago, Chile.Journal Article19700101<span style="text-decoration: underline;">Background</span>: The limitations of total serum PSA values remain problematic, especially after an initial negative prostate biopsy. In this prospective study of Chilean men with a continued suspicion of prostate cancer due to a persistently elevated total serum PSA, abnormal digital rectal examination and initial negative prostate biopsy were compared with the use of the on-line Chun nomagram, detection of primary malignant circulating prostate cells (CPCs) and free percent PSA to predict a positive second prostate biopsy. We hypothesized that men negative for circulating prostate cells have a small risk of clinically significant prostate cancer and thus may be conservatively observed. Men positive for circulating prostate cells should undergo biopsy to confirm prostate cancer.
<span style="text-decoration: underline;">Materials and Methods</span>: Consecutive men with a continued suspicion of prostate cancer underwent 12 core TRUS prostate biopsy; age, total serum PSA and percentage free PSA and Chun nomagram scores were registered. Immediately before biopsy an 8ml blood simple was taken to detect primary mCPCs. Mononuclear cells were obtained by differential gel centrifugation and identified using double immunostaining with anti-PSA and anti-P504S. Biopsies were classifed as cancer/no-cancer, mCPC detecton test as negative/positive and the total number of cells/8ml registered. Areas under the curve (AUC) for percentage free PSA, Chun score and CPCs were calculated and compared. Diagnostic yields were calculated with reference to the number of possible biopsies that could be avoided and the number of clinically significant cancers that would be missed.
<span style="text-decoration: underline;">Results</span>: A total of 164 men underwent a second biopsy; 41 (25%) had cancer; the AUCs were 0.65 for free PSA, 0.76 for the Chun score and 0.87 for CPC detection, the last having a significantly superior prediction value (p=0.01). Using cut off values of free PSA <10%, Chun score >50% and ≥1 CPC detected, CPC detection had a higher diagnostic yield. Some 4/41 cancers complied with the criteria for active surveillance, free PSA and the Chun score missed a higher number of significant cancers when compared with CPC detection.
<span style="text-decoration: underline;">Conclusions</span>: Primary CPC detection outperformed the use of free PSA and the Chun nomagram in predicting clinically significant prostate cancer at repeat prostate biopsy.https://journal.waocp.org/article_16363_7e6884ebcf9c47b8eb0dcbef8ef783f2.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Development of a Health Education Modification Program Regarding Liver Flukes and Cholangiocarcinoma in High Risk Areas of Nakhon Ratchasima Province Using Self-Efficacy and Motivation Theory2947295116366APJCP.2016.17.6.2947ENSoraya JKaewpitoonParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandSorayaKaewpitoonParasitic Disease Research Unit,Khon Kaen University, Khon Kaen, ThailandSchool of Family Medicine and Community Medicine Khon Kaen University, Khon Kaen, ThailandSuranaree University of Technology
Hospital, Suranaree University of Technology, Khon Kaen University, Khon Kaen, ThailandRatanaRujirakulParasitic Disease Research Unit,Khon Kaen University, Khon Kaen, ThailandParichartWakkuwattapongParasitic Disease Research Unit,Khon Kaen University, Khon Kaen, ThailandFuangfaBenjaoranSchool of Family Medicine and Community Medicine Khon Kaen University, Khon Kaen, ThailandSuranaree University of Technology Hospital, Suranaree University of Technology, Khon Kaen University, Khon Kaen, ThailandJunNorkaewFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen University, Khon Kaen, ThailandJirawootKujapunFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen University, Khon Kaen, ThailandSukanyaPonphimaiFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen University, Khon Kaen, ThailandWasugreeChavenkunFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen University, Khon Kaen, ThailandPorntipKomporFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen University, Khon Kaen, ThailandNatnapaPadchasuwanFaculty
of Public Health, Khon Kaen University, Khon Kaen, ThailandNatthawutKaewpitoonSchool of Family Medicine and Community Medicine Khon Kaen University, Khon Kaen, ThailandSuranaree University of Technology
Hospital, Suranaree University of Technology, Khon Kaen University, Khon Kaen, ThailandFaculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Khon Kaen University, Khon Kaen, ThailandJournal Article19700101A quasi-experimental study was conducted to develop a health education modification program based on self-efficacy and motivation regarding liver flukes and cholangiocarcinoma development in Keang Sanam Nang district, Nakhon Ratchasima province, Thailand. A total of 36 individuals were invited to participate in the program and were screened for population at risk of liver fluke infection and cholangiocarcinoma using SUT-OV-001 and SUT-CCA-001. Development of health education modification program regarding liver fluke and cholangiocarcinoma prevention included 3 steps: (1) preparation, (2) health education program, and (3) follow-up and evaluation. The study was implemented for 10 weeks. Pre-and-post-test knowledge was measured with questionnaires, Kuder-Richardson-20: KR-20 = 0.718,and Cronbach’s Alpha Coefficient = 0.724 and 0.716 for percection and outcome expectation questionnaires. Paired and independent t-tests were applied for data analysis. The majority of the participants were female (55.6%), aged between ≤50 and 60 years old (36.1%), married (86.1%), education level of primary school (63.9%), agricultural occupation (80.6%), and income <4,000 Baht (44.4%). The results revealed that after the health education program, the experimental group had a mean score of knowledge, perception, and outcome expectation regarding liver fluke and cholangiocarcinoma prevention significantly higher than before participation and in the control group. In conclusion, this successful health education modification program for liver fluke and cholangiocarcinoma, therefore may useful for further work behavior modification in other epidemic areas.https://journal.waocp.org/article_16366_9d815c3a7e76cb644f8c0cc470d4ebc6.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Metastasis Risk Reduction Related with Beta-Blocker Treatment in Mexican Women with Breast Cancer2953295716371APJCP.2016.17.6.2953ENEParada-HuertaNaval Medical School, Secretary of the Navy, MexicoJA DiazPonce-MedranoEParada-HuertaNaval Medical School, Secretary of the Navy, SEMAR, MexicoTPAlvarez-DominguezDepartment of Pathology, High- Specialty Naval General Hospital (HOSGENAES), SEMAR, MexicoRUribe-EscamillaDivision of
Neurosciences, National Institute of Rehabilitation (INR), CDMX, MexicoJFRodriguez-JoyaNaval Clinic South (CLINISUR), SEMAR, MexicoJA DiazPonce-MedranoDirector’s Office, Naval Medical School, SEMAR, MexicoSPadron-Lucio6Branch, Naval Medical School, SEMAR, MexicoAAlfaro-RodriguezDivision of
Neurosciences, National Institute of Rehabilitation (INR), CDMX, MexicoCBandalaDivision of
Neurosciences, National Institute of Rehabilitation (INR), CDMX, MexicoJournal Article19700101<span style="text-decoration: underline;">Background</span>: Breast Cancer (BCa) is the most common malignant tumour in Mexican women. In BCa, several studies have linked β2-adrenergic receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation. The aim of this study was to describe Beta-Blocker (BB) treatment related with reduction of the risk of metastasis in Mexican patients with BCa.
<span style="text-decoration: underline;">Materials and Methods</span>: We collected data of 120 patients seen at the High-Specialty Naval General Hospital in Mexico City (HOSGENAES), all of these with a histopathological diagnosis of BCa. Four groups of patients were divided as follows: without Systemic Arterial Hypertension (SAH); with SAH treatment with non-selective BB; with SAH treatment with selective BB, and with SAH treatment with other antihypertensive drugs. Chi-square, Mantel- Haenszel, Student t, and ANOVA tests were performed for data analysis.
<span style="text-decoration: underline;">Results</span>: On average, patients were 54.8±11.8 years of age. Risk factors such as smoking and consuming alcohol exhibited a frequency of 33 and 36.5% respectively. Clinical stages III- IV were found in 50% of patients, while, 30% of patients had arterial hypertension (n=29 and N=96, respectively) and 17.5% used BB. One hundred percent of patients with arterial hypertension treated with BB for β1 - and β2 -adrenergic-receptors did not present metastasis globally, but patients treated with β1 BB presented 30% of metastasis while patients treated with no BB or without SAH had around 70% of metastasis.
<span style="text-decoration: underline;">Conclusions</span>: In Mexican patients with BCa and SAH treated with non-selective (β1- and β2-adrenergic receptors) BB, a decrease in the risk for metastasis was observed at the time of diagnosis.https://journal.waocp.org/article_16371_bf9ddca3a2e9f80f5643c2550b4f1b55.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Possible Epithelial Ovarian Cancer Association with HPV18 or HPV33 Infection2959296416376APJCP.2016.17.6.2959ENPei-PeiZhangJishou University, Datianwan, Jishou, ChinaEqual contributorsLeiZhouHunan Normal University, Changsha, ChinaEqual contributorsJia-ShiCaoHunan Normal University, Changsha, ChinaEqual contributorsYi-PingLiHunan Normal University, Changsha, ChinaEqual contributorsZhiZengMaternal and Child health Hospital of Hunan, Changsha, ChinaNiSunHunan Normal University, Changsha, ChinaLiShenHunan Normal University, Changsha, ChinaHao-YueZhuHunan Normal University, Changsha, ChinaYangRuanHunan Normal University, Changsha, ChinaWen-TingZhaHunan Normal University, Changsha, ChinaXin-YuWangHunan Normal University, Changsha, ChinaKe-QiangZhangHunan Cancer Hospital, Changsha, ChinaRanZhangJishou University, Datianwan, Jishou, ChinaHunan Normal University, Changsha, ChinaJournal Article19700101The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data. The prevalence of HPV18 and HPV33 in EOC group and benign group was higher than in the normal group. HPV18 and HPV33 may play a role in the development of both EOC and ovarian benign tumor and may participate in the development of EOC with traditional risk factors, family history and abortion, possibly exerting synergistic effects.https://journal.waocp.org/article_16376_04676f154618279fa54284f2e5439fc7.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Knowledge of Cervical Cancer Screening among Health Care Workers Providing Services Across Different Socio-economic Regions of China2965297216377APJCP.2016.17.6.2965ENJiang-LiDiNational Centre for Women and Children's Health, China CDC, Beijing, ChinaBoSongJiang-LiDiNational Centre for Women and Children’s Health, China CDC, Beijing, ChinaGriffith University; Brisbane, Queensland, AustraliaShannonRutherfordGriffith University; Brisbane, Queensland, AustraliaJiu-LingWuNational Centre for Women and Children’s Health, China CDC, Beijing, ChinaBoSongNational Centre for Women and Children’s Health, China CDC, Beijing, ChinaLanMaNational Centre for Women and Children’s Health, China CDC, Beijing, ChinaJing-YiChenNational Centre for Women and Children’s Health, China CDC, Beijing, ChinaCordiaChuGriffith University; Brisbane, Queensland, AustraliaJournal Article19700101<span style="text-decoration: underline;">Background</span>: China carries a heavy burden of cervical cancer (CC) and substantial disparities exist across regions within the country. In order to reduce regional disparities in CC, the government of China launched the National Cervical Cancer Screening Program in Rural Areas (NCCSPRA) in 2009. Critical to the success of the program are the health care workers who play a pivotal role in preventing and managing CC by encouraging and motivating women to use screening services and by providing identification and treatment services. This study aimed to assess cervical cancer knowledge among these health care workers at the county level in maternal and child health (MCH) hospitals across different socio-economic regions of China. <span style="text-decoration: underline;">Materials and Methods</span>: A cross-sectional survey was conducted and self-administered questionnaires were sent to all health care workers (a total of 66) providing cervical cancer screening services in 6 county level MCH hospitals in Liaoning, Hubei and Shaanxi provinces, representing eastern, central and western regions of China; 64 (97.0%, 64/66) of the workers responded. ANOVA and Chi-square test were used to compare the knowledge rate and scores in subgroups. <span style="text-decoration: underline;">Results</span>: The knowledge level of the respondents was generally low. The overall combined knowledge rate was 46.9%. The knowledge rates for risk factors, prevention, clinical symptoms, screening and diagnostic tests and understanding of positive results were 31.3%, 37.5%, 18.1%, 56.3% and 84.4%, respectively. Statistically significant differences in scores or rates of CC knowledge were seen across the different regions. The total and sectional scores in the less developed regions were statistically significantly lower than in the other regions. <span style="text-decoration: underline;">Conclusions</span>: The majority of the health care workers who provide CC screening service in NCCSPRA at county level MCH hospitals do not have adequately equipped with knowledge about CC. Given the importance of knowledge to the program’s success in reducing CC burden in rural women in China, efforts are needed to improve the knowledge of health care workers, especially in less developed regions.https://journal.waocp.org/article_16377_110203177e7a6d7a5bd74c5a6eff3aeb.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Opisthorchis viverrini Infection Among People in the Border Areas of Three Provinces, Northeast of Thailand2973297716378APJCP.2016.17.6.2973ENSoraya JKaewpitoonParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandRujirakulWakkuwattapongSoraya JKaewpitoonParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandSchool of Family Medicine and Community Medicine, Suranaree University of Technology, Nakhon Ratchasima, ThailandSuranaree University of Technology
Hospital, Suranaree University of Technology, Nakhon Ratchasima, ThailandRatanaRujirakulParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandParichartWakkuwattapongParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandLikitMatrakoolSuranaree University of Technology Hospital, Suranaree University of Technology, Nakhon Ratchasima, ThailandSchool of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, ThailandTaweesakTongtaweeSuranaree University of Technology Hospital, Suranaree University of Technology, Nakhon Ratchasima, ThailandSchool of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, ThailandSukijPanpimanmasSuranaree University of Technology Hospital, Suranaree University of Technology, Nakhon Ratchasima, ThailandSchool of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, ThailandPrasitPengsaaParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandDarawanJomkoaParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandApinyaJoosiriParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandNatthawutKaewpitoonParasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, ThailandSuranaree University of Technology Hospital, Suranaree University of Technology, Nakhon Ratchasima, ThailandFaculty of Public Health, Vongchavalitkul
University, Nakhon Ratchasima, ThailandJournal Article19700101<em>Opisthorchis viverrini </em>is still a serious problem in Northeastern and Northern Thailand. Active surveillance is required to determine updated data for further prevention and control planning. Therefore, this study aimed to examine the prevalence and risk factors for <em>O. viverrini </em>in three provinces, Northeastern Thailand. A cross-sectional survey was conducted during October 2015 to March 2016 at Kaeng Sanam Nang district of Nakhon Ratchasima province, Waeng Noi district of Khon Kaen province, and Khon Sawan district of Chaiyaphum province, Thailand. Stool samples were examined by using a modified Kato-Katz Thick smear technique. From a total of 978 participants screened, <em>O. viverrini </em>infection was found in 1.74%, the majority opf positive cases being male (6.62%), age group 51-60 years old (4.21%), educated at primary school (8.43%), occupied with agriculture (9.62%),having an income <4,000 baht per month (4.82%), and living in Khon Sawan district (8.43%). Participants had a high knowledge level (42.43%), good attitude level (34.76%), and fair level (38.04%). The present study indicates the <em>O. viverrini </em>infection rate is low, but elderly males with primary school education involved in agriculture are still frequently effected particularly in Khon Sawan district. Therefore, this risk g roup requires behavior modification and continued monitoring.https://journal.waocp.org/article_16378_dce94accc908820def85cf4ae60dad6c.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Reduced Ovarian Cancer Incidence in Women Exposed to Low Dose Ionizing Background Radiation or Radiation to the Ovaries after Treatment for Breast Cancer or Rectosigmoid Cancer2979298216379APJCP.2016.17.6.2979ENStevenLehrerDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, USAStevenLehrerDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, USA.SherylGreenDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, USA.KennethRosenzweigDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, USA.Journal Article19700101
<span style="text-decoration: underline;">Background</span>: High dose ionizing radiation can induce ovarian cancer, but the effect of low dose radiation on the development of ovarian cancer has not been extensively studied. We evaluated the effect of low dose radiation and total background radiation, and the radiation delivered to the ovaries during the treatment of rectosigmoid cancer and breast cancer on ovarian cancer incidence. <span style="text-decoration: underline;">Materials and Methods</span>: Background radiation measurements are from <em>Assessment of Variations in Radiation Exposure in the United States</em>, 2011. Ovarian cancer incidence data are from the Centers for Disease Control and Prevention. Standardized incidence ratios (SIR) of ovarian cancer following breast cancer and rectosigmoid cancer are from Surveillance, Epidemiology, and End Results (SEER) data. Obesity data by US state are from the Centers for Disease Control and Prevention. Mean ages of US state populations are from the United States Census Bureau. <span style="text-decoration: underline;">Results</span>: We calculated standardized incidence ratios (SIR) from Surveillance, Epidemiology, and End Results (SEER) data, which reveal that in 194,042 cases of breast cancer treated with beam radiation, there were 796 cases of ovarian cancer by 120+ months of treatment (0.41%); in 283, 875 cases of breast cancer not treated with radiation, there were 1,531 cases of ovarian cancer by 120+ months (0.54%). The difference in ovarian cancer incidence in the two groups was significant (p < 0.001, two tailed Fisher exact test). The small dose of scattered ovarian radiation (about 3.09 cGy) from beam radiation to the breast appears to have reduced the risk of ovarian cancer by 24%. In 13,099 cases of rectal or rectosigmoid junction cancer treated with beam radiation in the SEER data, there were 20 cases of ovarian cancer by 120+ months of treatment (0.15%). In 33,305 cases of rectal or rectosigmoid junction cancer not treated with radiation, there were 91 cases of ovarian cancer by 120+ months (0.27%). The difference in ovarian cancer incidence in the two groups was significant (p = 0.017, two tailed Fisher exact test). In other words, the beam radiation to rectum and rectosigmoid that also reached the ovaries reduced the risk of ovarian cancer by 44%. In addition, there was a significant inverse relationship between ovarian cancer in white women and radon background radiation (r = - 0.465. p = 0.002) and total background radiation (r = -0.456, p = 0.002). Because increasing age and obesity are risk factors for ovarian cancer, multivariate linear regression was performed. The inverse relationship between ovarian cancer incidence and radon background was significant (ß = - 0.463, p = 0.002) but unrelated to age (ß = - 0.080, p = 0.570) or obesity (ß = - 0.180, p = 0.208). <span style="text-decoration: underline;">Conclusions</span>: The reduction of ovarian cancer risk following low dose radiation may be the result of radiation hormesis. Hormesis is a favorable biological response to low toxin exposure. A pollutant or toxin demonstrating hormesis has the opposite effect in small doses as in large doses. In the case of radiation, large doses are carcinogenic. However, lower overall cancer rates are found in U.S. states with high impact radiation. Moreover, there is reduced lung cancer incidence in high radiation background US states where nuclear weapons testing was done. Women at increased risk of ovarian cancer have two choices. They may be closely followed (surveillance) or undergo immediate prophylactic bilateral salpingo-oophorectomy. However, the efficacy of surveillance is questionable. Bilateral salpingo-oophorectomy is considered preferable, although it carries the risk of surgical complications. The data analysis above suggests that low-dose pelvic irradiation might be a good third choice to reduce ovarian cancer risk. Further studies would be worthwhile to establish the lowest optimum radiation dose.https://journal.waocp.org/article_16379_239265e073c1e0dc8acfbd56087e0d5a.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Prioritizing the Preferences of Iranian Cancer Patients Regarding Acquisition of Health Information: Strategy for Patient Education2983298816380APJCP.2016.17.6.2983ENJamileh MahdiZadehMedical school of Semnan university of medical sciences, Semnan, IranFarahnaz GhahremanFardJamilehMahdi ZadehMedical school of Semnan university of medical sciences, Semnan, IranFarahnazGhahreman FardSocial Determinant of Health Research Center, Semnan University of Medical Sciences, Semnan, IranRaihanehMadaniNursing and Allied Health
School, Semnan University of Medical Sciences, Semnan, IranHomaIravaniNursing and Allied Health
School, Semnan University of Medical Sciences, Semnan, IranMehdiKahoueiNursing and Allied Health
School, Semnan University of Medical Sciences, Semnan, IranJournal Article19700101Recognizing cancer patients’ preferences to obtain health information can help improve and reform the methods of communicating and providing proper services and consequently lead to effective patient education. The present cross-sectional study to prioritize the preferences of cancer patients regarding the acquisition of health informationwas conducted on cancer patients referred to hospitals affiliated to Semnan University of Medical Sciences in 2015. An anonymous self-administered questionnaire was developed. In the field of side effects of medications, 50 (46.7%) reported knowing about weight change, in the area of achieving relative health, 62(57.9%) announced awareness about diet, and 45 (42.1%) reported physical complications as a first regarding information needs. In the area of obtaining information, 50 (46.7%) tended to take their information through means outside of the hospital setting. These results can help with design of clinical information systems, as they inform the most relevant and useful coverage designed for cancer patients. Providing useful information through healthcare providers, the media and clinical information systems can act as a major source of social support for cancer patients.https://journal.waocp.org/article_16380_f882206d7c839b672935c37012956aae.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Circulating DNA in Egyptian Women with Breast Cancer2989299316381APJCP.2016.17.6.2989ENIman HassanIbrahimBiochemistry Department, Faculty of Pharmacy for Girls -Al Azhar University, Cairo, EgyptImanHassan IbrahimBiochemistry Department, Faculty of Pharmacy for Girls -Al Azhar University, Cairo, EgyptMahmoud MKamelClinical Pathology Department, Cairo University, Cairo, EgyptMohamedGhareebDepartment
of Medical Oncology, National Cancer Institute, Cairo University, Cairo, EgyptJournal Article19700101The commonest cancer in Egyptian females occurs in the breast cfDNA is a non-invasive marker for tumor detetion and prognostic assessment in many types of cancer including breast cancer. This study aimed to assess the role of cfDNA and its fragmentation pattern in breast cancer prognosis and treatment response. Forty female patients with malignant breast tumors and a comparable group of healthy blood donors were enrolled prospectively. cfDNA levels and fragmentation patterns were investigated after cfDNA extraction, gel electrophoresis and gel analysis. The percentage of breast cancer patients positive for cfDNA (92.5%) was significantly higher than that of controls (55%). Also, mean concentration of cfDNA was significantly higher than in the control group (P<0.05). Most Her-2 positive patients had long cfDNA fragments, this being significant as compared to Her-2 negative patients (P<0.05). Metastasis was also positively linked to significantly higher cfDNA (P<0.05) and the mean cfDNA integrity index was significantly higher in non-responders compared to treatment responders (P<0.05). In conclusion, both qualitative and quantitative aspects of cfDNA and its different fragments in breast cancer patients could be related to prognosis, metastasis and treatment response. Long cfDNA fragments could be particularly useful for prediction purposes.https://journal.waocp.org/article_16381_530754631a1e8850c64f3ff1d7b90627.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Eight Year Survival Analysis of Patients with Triple Negative Breast Cancer in India2995299916382APJCP.2016.17.6.2995ENDineshChandraDepartment of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, IndiaDineshChandra DovalDepartment of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaDepartment of Research, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaPSureshDepartment of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaRupalSinhaDepartment of Research, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaSaudAzamDepartment of Research, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaUllasBatraDepartment of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaVineetTalwarDepartment of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaKapilKumarDepartment of Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaAnuragMehtaDepartment of Laboratory Services,
Rajiv Gandhi Cancer Institute & Research Centre, Delhi, IndiaJournal Article19700101<span style="text-decoration: underline;">Background</span>: Triple-negative breast cancer (TNBC) often presents as an interval cancer with short survival upon metastasis and thus represents an important clinical challenge. The present study investigated the clinicopathologic characteristics and long term survival outcome of early and locally advanced TNBC.
<span style="text-decoration: underline;">Materials and Methods</span>: Medical records were reviewed retrospectively for 148 consecutive confirmed cases of TNBC treated in a single unit at our centre. Demographic profile, tumor type, histopathology details, treatment and follow-up information was recorded and immunohistochemistry was performed.
<span style="text-decoration: underline;">Results</span>: Age group >50 years was associated with tumors of clinical stage 3 (53.8%), pathological stage 3 (46.2%), pathological grade 3 (45.7%), presence of extracapsular extension (ECE, 48.5%) and lymphovascular invasion (LVI, 64.9%). Locally advanced breast cancers (LABCs) were characterized by pathological stage 3 (96.2%), presence of ECE (100%) and absence of LVI (46.7%) as compared to early breast cancers (EBCs) which had higher incidence of lower stage tumors (100%), absence of ECE (82%) and presence of LVI (91.9%; p-value Conclusions: TNBCs are aggressive tumors which show poor long term survival. Patients with TNBC benefit from chemotherapy, thus better and less toxic treatment options are needed. Identification of newer targets and development of targeted therapies are the need of the hour.https://journal.waocp.org/article_16382_cf80590096923aa7a52d3b8957ffc530.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Genetic Abnormalities in Oral Leukoplakia and Oral Cancer Progression3001300616383APJCP.2016.17.6.3001ENTae JunKilYonsei Empathy Dental Clinic, Department of Oral and Maxillofacial Surgery, Yonsei University, Seoul, KoreaTae JunKilYonsei Empathy Dental Clinic, Department of Oral & Maxillofacial Surgery, Seoul, KoreaHyunKimOral Cancer Research Institute,
Yonsei University, Seoul, KoreaHyung JunKimCollege of Dentistry,
Yonsei University, Seoul, KoreaWoongNamCollege of Dentistry,
Yonsei University, Seoul, KoreaIn-HoChaOral Cancer Research Institute,
Yonsei University, Seoul, KoreaCollege of Dentistry,
Yonsei University, Seoul, KoreaJournal Article19700101<span style="text-decoration: underline;">Background</span>: The cancer progression of oral leukoplakia is an important watchpoint in the follow-up observation of the patients. However, potential malignancies of oral leukoplakia cannot be estimated by histopathologic assessment alone. We evaluated genetic abnormalities at the level of copy number variation (CNV) to investigate the risk for developing cancer in oral leukoplakias.
<span style="text-decoration: underline;">Materials and Methods</span>: The current study used 27 oral leukoplakias with histological evidence of dysplasia. The first group (progressing dysplasia) consisted of 7 oral lesions from patients with later progression to cancer at the same site. The other group (non-progressing dysplasia) consisted of 20 lesions from patients with no occurrence of oral cancer and longitudinal follow up (>7 years). We extracted DNA from Formalin-Fixed Paraffin-Embedded (FFPE) samples and examined chromosomal loci and frequencies of CNVs using Taqman copy number assays.
<span style="text-decoration: underline;">Results</span>: CNV frequently occurred at 3p, 9p, and 13q loci in progressing dysplasia. Our results also indicate that CNV at multiple loci–in contrast to single locus occurrences–is characteristic of progressing dysplasia.
<span style="text-decoration: underline;">Conclusions</span>: This study suggests that genetic abnormalities of the true precancer demonstrate the progression risk which cannot be delineated by current histopathologic diagnosis.https://journal.waocp.org/article_16383_5abcbc5500f79d26c8edc9f27895ef9e.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Evaluating Direct Costs of Gastric Cancer Treatment in Iran - Case Study in Kerman City in 20153007301316384APJCP.2016.17.6.3007ENAzarIzadiMsc in Health services management, Kerman University of medical sciences, Kerman, IranMohammad JaffariSiriziAzarIzadiHealth Services Management, Kerman University of Medical
Sciences, Kerman, IranMohammadJaffari SiriziHealth Insurance Organization, Kerman Office,Kerman, IranSafaEsmaeelpourShafa Hospital, Kerman University of Medical Sciences, Kerman, IranMohsenBarouniHealth Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical
Sciences, Kerman, IranJournal Article19700101<span style="text-decoration: underline;">Background</span>: Gastrointestinal cancers are common malignancies associated with high mortality rates. Health-care systems are always faced with high costs of treatment of gastrointestinal cancers including stomach cancer. Identification and prioritization of these costs can help determine economic burden and then improve of health planning by policy-makers. This study was performed in 2015 in Kerman City aimed at estimating the direct hospital costs for patients with gastric cancer.
<span style="text-decoration: underline;">Materials and Methods</span>: In this cross-sectional study, the medical records of 160 patients with stomach cancer admitted from 2011 to 2014 to Shafa Hospital were examined, the current stage of the disease and the patients’ health status were identified, and the direct costs related to the type of treatment in the public and private sectors were calculated. SPSS-19 was used for statistical analysis of the data.
<span style="text-decoration: underline;">Results</span>: Of the patients studied, 103 (65%) were men and 57 (35%) were women. The mean age of patients was 65 years. Distribution into four stages of the disease was 5%, 20%, 30%, and 45%, respectively. Direct costs in four stages of the disease were calculated as 2191.07, 2642.93, 2877, and 2674.07 USD (63,045,879, 76,047,934, 82,783,019, and 76,943,800 IRR), respectively. The highest percentage of costs was related to surgery in Stage I and to medication in Stages II, III, and IV. According to the results of direct costs of treatment for stomach cancer in Kerman, the mean total cost of treating a patient in the public sector was estimated at 74,705,158 IRR, of which averages of 60,141,384 IRR and 14,563,774 IRR were the shares of insurance and patients, respectively.
<span style="text-decoration: underline;">Conclusions</span>: The high prevalence and diagnosis of disease in old age and at advanced stages of disease impose great costs on the patients and the health system. Early diagnosis through screening and selecting an appropriate treatment method might largely ameliorate the economic burden of the disease.https://journal.waocp.org/article_16384_b034d8bfc5cc2a88fe48eb859d55ccf4.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis3015302016385APJCP.2016.17.6.3015ENKhadijeh MirzaeeKhoram-AbadiDepartment of Anatomy, Shahid Sadoughi University of Medical Sciences, Yazd, IranKhadijehMirzaee Khoram-AbadiDepartment of Anatomy,Shahid
Sadoughi University of Medical Sciences, Yazd, IranMohammadForat-YazdiDepartment of Internal Medicine, Shahid
Sadoughi University of Medical Sciences, Yazd, IranShahnazKheirandishDepartment of Internal Medicine, Shahid
Sadoughi University of Medical Sciences, Yazd, IranNasimSaeidiDepartment of Internal Medicine, Shahid
Sadoughi University of Medical Sciences, Yazd, IranZeinabZarezadeDepartment of Internal Medicine, Shahid
Sadoughi University of Medical Sciences, Yazd, IranNahidMehrabiDepartment of Biology, Science Faculty, University of Yazd, IranHosseinNeamatzadehDepartment of Medical Genetics, Internationl Campus, Shahid
Sadoughi University of Medical Sciences, Yazd, IranJournal Article19700101<span style="text-decoration: underline;">Background</span>: Numerous studies have investigated associations of DNA methyltransferase (DNMT) -149 C>T and -579 G>T polymorphisms with gastric cancer (GC) and colorectal cancer (CRC) susceptibility; however, the findings are inconsistent prompting the present meta-analysis.
<span style="text-decoration: underline;">Materials and Methods</span>: Related studies were identified from PubMed, Google scholar, and SID until 10 October 2015. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations.
<span style="text-decoration: underline;">Results</span>: Eleven studies were included based on the search criteria for CRC and GC related to the DNMT3B 149 C>T (3,353 cases and 4,936 controls) and DNMT3B 579 G>T (1,387 cases and 2,064 controls) polymorphisms. There was no significant association overall between DNMT3B -149 and 579 polymorphisms and the risk of cancer. In the stratified analysis by cancer type, DNMT3B 579G>T polymorphism was associated with the risk of CRC and GC. While the DNMT3B -149C/T polymorphism was related with a significantly increased risk of CRC in two tested models, dominant (GG+GT <em>vs. </em>TT: OR 0.51, 95 % CI 0.38-0.69; P = 0.00, Pheterogeneity=0.69, I2= 0 %) and heterozygote (GT <em>vs. </em>TT: OR 0.50, 95 % CI 0.37-0.69; P=0.00, Pheterogeneity=0.41, I2= 0 %), no evidence of any association with GC risk was observed as in the pooled analyses.
<span style="text-decoration: underline;">Conclusions</span>: More studies are needed to assess associations of DNMT3B -149C/T and DNMT3B 579G>T polymorphisms with cancer in different ethnicities with large population sizes to generate comprehensive conclusionshttps://journal.waocp.org/article_16385_d3d0c784e9ee716911290ee8e41167c1.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-736817620160701Auto-Coding of Cancer Registry Data in China3021302316386APJCP.2016.17.6.3021ENKuang RongWeiZhongshan Cancer Registry, Zhongshan, Beijing, ChinaKuangWeiZhongshan Cancer Registry, Zhongshan,Beijing, ChinaSheng ChaoLiuDepartment
of Technology, Dimensional Insight, Massachusetts, USADonglingWeiComputer Science Department, Dartmouth College, New Hampshire, USAZhihengLiangZhongshan Cancer Registry, Zhongshan,Beijing, ChinaWanqingChenChinese National Office for Cancer Prevention and Control, Beijing, ChinaJournal Article19700101The significance, difficulty and strategy of coding cancer data according to international coding standards are discussed, and the concept, methods and realization of cancer data automatic coding in cancer registries in China are introduced in the paper. Coding cancer data automatically with software could not only reduce the time, manpower and workload, while improving the accuracy and efficiency of cancer data coding, but also e nhance the validity of cancer registration and the value of cancer registry data, which is of great significance.https://journal.waocp.org/article_16386_71644312b1d45985554e39ddda6f71d6.pdf