West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Overview of the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)1824672ENJournal Article19700101Starting in the late 1980s a major collaborative effort has been carried out in Japan to increase knowledgeabout factors contributing to mortality from cancer and circulatory disease. This Japan Collaborative CohortStudy (JACC Study) is sponsored by the Ministry of Education, Science, Sports and Culture of Japan(Monbukagakusho) and has contributions from 45 areas of the country. With Drs Kunio Aoki and YoshiyukiOhno as leading figures in this endeavour, the cohort now covers more than 100,000 participants enrolled atvarious centers located from Hokkaido in the North to Kyushu in the South. To collect epidemiological informationat baseline, a self-administered questionnaire was used. Follow-up up was to 2003 in the majority of cases anda total of 17,404 deaths were registered, the five commonest sites of cancer development being the lung, stomach,liver, pancreas and colon in men, and the stomach, lung, liver, colon and pancreas in women.https://journal.waocp.org/article_24672_f102fb724fc83ca912c660da18ad8a37.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Personal Past History and Mortality in the JapanCollaborative Cohort Study for Evaluation of Cancer (JACC)92024673ENJournal Article19700101To determine the influence of personal medical history on mortality from cancer and other chronic diseases,participants in the JACC study were questionned and followed up. Consistent across the sexes, risk of deaths ofall causes was increased with hypertension, diabetes mellitus, apoplexy, liver diseases, surgical operations, andblood transfusions. All cancers were similarly related to a history of diabetes and liver diseases, surgery andtransfusions. In addition, risk of liver cancer was elevated with diabetes, liver disease, cholecystectomy, renaldisease, surgical operations and blood transfusions. Apoplexy was related to a past history of blood transfusionand diabetes, the latter also predisposing to ischemic heart disease. Links with infectious disease were alsoelucidated. Clearly, a past medical history can exert a strong influence on chronic disease development.https://journal.waocp.org/article_24673_7e043a6c45adbb7eeba3df3f9a0c8d42.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Family History and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)212424674ENJournal Article19700101To determine the influence of family medical history on mortality from cancer and other chronic diseases,participants in the JACC study were questioned about tuberculosis, apoplexy, hypertension, heart disease, diabetesmellitus and malignant diseases and followed up. Consistent across the sexes, a family history of tuberculosiswas apparently linked to reduced risk of lung cancer, and also lowered ischemic heart disease. No consistentfindings were obtained for hypertension, diabetes mellitus or cancer.https://journal.waocp.org/article_24674_0e58c466a838d40784d7e6dcb6ed7b45.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Health Conditions and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)253424675ENJournal Article19700101General health conditions were examined for their influence on mortality in the Japan Collaborative Cohort.Constipation was found to be associated with total death and cerebrovascular disease (CVD). Increased riskwas also the case for excessive sleeping and napping and elevated susceptibility to colds and expectoration.Eczema increased the risk of liver cancer. In contrast, exercise proved protective against all causes of death,some cancers, ischemic heart disease (IHD) and CVD. Spending a long time watching TV, as expected, had theopposite effect. A positive attitude towards screening was also linked with lower risk of most chronic diseases.https://journal.waocp.org/article_24675_df404e5f378df9d2d829bf2510869a04.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Nutrition and Disease in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)358024676ENJournal Article19700101Nutrition effects on mortality in the Japan Collaborative Cohort Study (JACC Study) were investigatedusing interview and follow up. Multivitamin and vitamin E use was found to be associated with lower mortalityfrom cerebrovascular disease (CVD). For all causes, CVD and ischemic heart disease (IHD), total energy intakeand cutting breakfast were associated with elevated, while rice intake, fruit, sweets, tofu, pickles, dried fish,deep-fried foods, tea and coffee and seaweed were generally linked with lowered mortality. Consistent acrossthe sexes, protection was evident against lung cancer with seaweed, prostate cancer with fresh fish, and livercancer with pork and rice intake. Positive associations were found between potato consumption and colon cancer,as well as for fat intake and liver cancer. Clearly, the diet has a major impact on chronic disease processes in theJapanese population.https://journal.waocp.org/article_24676_2f4726bd0e9ae6633d06bf171be7040f.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Alcohol Use and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)818824677ENJournal Article19700101Alcohol use was examined for its influence on mortality in the Japan Collaborative Cohort. While overallrisk of death, as well as ischemic heart disease, were reduced with moderate consumption, increase was notedwith heavy intake, even after cessation. With heavy consumption, overall cancers were also increased. In males,risk of oesophageal cancer was particularly elevated and risk of liver and renal cancer was found to be increasedin ex-drinkers. Heavy consumption appears to be also a risk factor for rectal and gallbladder cancer. Furthermore,cerebrovascular disease was increased with dose-dependence.https://journal.waocp.org/article_24677_9addccdbd9f008a0da7c91b3ba23a0ed.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Smoking and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)899624678ENJournal Article19700101In the JACC study, risk of death with all cancers and all causes was found to be increased with activesmoking,with and without dose-dependence, respectively. Death from both of the circulatory diseases was alsoadversely affected. The younger the age at commencing the habit, the greater the effect, with diminution aftercessation. Regarding particular cancers, strong evidence was noted for the esophagus, liver, pancreas, lung andurothelium. Also links were apparent with gastric and gallbladder cancers and the breast in female ex-smokers.With passive smoking, the data were equivocal.https://journal.waocp.org/article_24678_8dff0c193c7fcfe89491ea1ad93a111a.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Occupational Factors and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)9710424679ENJournal Article19700101Occupational factors and mortality were assessed in the Japan Collaborative Cohort Study for evaluation ofcancer. Overall an elevated risk of death from all causes, all cancers and circulatory disease, particularly inmales, was found for those who were unemployed or to a lesser extent, self-employed. Certain cancers alsoshowed links. There was no difference in the risk of total death or death due to cancers between office workersand manual workers. However, manual workers of both sexes have a decreased risk of death due to colon cancerand of breast in females. In males, rotating shift work increased risk of total death and ischemic heart diseases.Slight increase overall with dusty and noisy environments, perceived stress linked with IHD and CVD.https://journal.waocp.org/article_24679_4bc1074e8e16b19e54144fa71cd01110.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Anthropometry, Development History and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)10511224680ENJournal Article19700101A number of characteristics, including body mass index (BMI), blood pressure and childhood location andeducational attainment were compared for their effects on mortality in the apan Collaborative Cohort Study(JACC Study). The lowest body mass index was associated with a higher risk of death overall in both sexes, butthe highest body mass index was also associated with a rise in risk in females. A low BMI was also linked withcertain cancers, for example in the lung and oesophagus. A higher body mass index was associated with a higherrisk of death due to ischemic heart disease. High blood pressure was also adversely linked to mortality, especiallyfrom ischemic heart and cerebrovascular diseases. The childhood environment also appeared to play a role,living in a city being associated with higher risk of mortality overall and from cancer. A high educational levelwas found to decrease the risk of total death and of cancer, particularly the lung and liver.https://journal.waocp.org/article_24680_70a0671323a71723e0680bf6f7a46499.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Psychological Factors and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)11312224681ENJournal Article19700101Psychological factors may have an influence on disease processes and therefore they were investigated in theJapan Collaborative Cohort Study. Overall there were very few consistent associations with cancer death. Personswith ‘ikigai’, defined as ‘that which most makes one’s life seem worth living’, demonstrated decreased risk ofmortality from all causes, ischemic heart disease (IHD) and cerebrovascular disease (CVD).There was noconsistent link with being quick to judge, although those answering no to quick judgement were at increasedrisk of all cause, IHD and CVD mortality. psychological stress was related to a slightly elevated risk of all causedeath, IHD in men and CVD in women. However, a sense of hurry was linked to a slightly reduced risk formortality from all causes and CVD. Persons who were likely to be angry had an increased risk for mortalityfrom all causes. In women not likely to be angry there were also positive links to death from cancers like breast.Joyfulness was associated with decreased mortality, especially from CVD. A feeling of being trusted was alsoprotective, again particularly for CVD.https://journal.waocp.org/article_24681_2bb1f426aaf703a3b9dc91b3ae456a13.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Marital Status and Having Children and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)12312824682ENJournal Article19700101Marital status has been identified as an important social factor associated with mortality. Interesting resultswere obtained in the present analyses of the Japan Collaborative Cohort Study. Death of spouse was positivelyassociated with risks of male death from all causes, all cancers, and ischemic heart diseases, compared withmarried status. Divorce or separation was positively associated with risks from all causes among men andwomen, all cancers among women, and single status was also positively associated with risks from all causesamong men and women, and ischemic heart diseases among men. Having large numbers of children was alsofound to be a risk factor.https://journal.waocp.org/article_24682_a6283c8f5b64b57b76270d3db8c8d958.pdfWest Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.Asian Pacific Journal of Cancer Prevention1513-73688Supplement20071201Reproductive History and Health Screening for Women and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)12913424683ENJournal Article19700101Reproductive history and participation in health screening for women were surveyed among female subjects,and interesting results were obtained in the present analyses. Women who had never experienced pregnancyhad significantly increased risks of death from all causes and cerebrovascular disorders compared with thosewho had experienced 1 or 2 pregnancies. In contrast, women who had experienced 3 or 4 pregnancies hadsignificantly decreased risks of death from all causes, all cancers, rectal cancer, and breast cancer. Among womenwho had ever undergone mass screening examination for uterine cervical cancer, there were significantly lowerrisks of death from all causes, all cancers, stomach cancer, uterine cervical cancer, urinary tract cancer, andischemic heart diseases compared with those who had not had such experience.https://journal.waocp.org/article_24683_60df916fdae28c6974b532b295f1c088.pdf