West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
HPV and Cervical Cancer Epidemiology - Current Status of HPV Vaccination in India
3663
3673
33037
EN
Sharmila
Chatterjee
Center for Global Health and Development University of Nebraska Medical Centre College of Public Health Omaha, NE, USA
Amit
Chattopadhyay
Luna
Samanta
Journal Article
1970
01
01
Cervical cancer (CaCx) is the second most fatal cancer contributing to 14% of cancers in Indian females, which account for 25.4% and 26.5% of the global burden of CaCx prevalence and mortality, respectively. Persistent infection with high-risk human papilloma virus (HPV- strains 16 and 18) is the most important risk factor for precursors of invasive CaCx. Comprehensive prevention strategies for CaCx should include screening and HPV vaccination. Three screening modalities for CaCx are cytology, visual inspection with acetic acid, and HPV testing. There is no Indian national policy on CaCx prevention, and screening of asymptomatic females against CaCx is practically non-existent. HPV vaccines can make a major breakthrough in the control of CaCx in India which has high disease load and no organized screening program. Despite the Indian Government's effort to introduce HPV vaccination in the National Immunization Program and bring down vaccine cost, challenges to implementing vaccination in India are strong such as inadequate epidemiological evidence for disease prioritization, duration of vaccine use, parental attitudes, and vaccine acceptance. This paper reviews the current epidemiology of CaCx and HPV in India, and the current status of HPV vaccination in the country. This article stresses the need for more research in the Indian context, to evaluate interventions for CaCx and assess their applicability, success, scalability and sustainability within the constraints of the Indian health care system.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Moringa oleifera Lam Targeting Chemoprevention
3675
3686
33038
EN
Nurul Ashikin Abd
Karim
Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia
Muhammad Din
Ibrahim
Saie Brindha
Kntayya
Yaya
Rukayadi
Hazrulizawati Abd
Hamid
Ahmad Faizal Abdull
Razis
Journal Article
1970
01
01
Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as "murungai" or "kelor". Glucomoringin, a glucosinolate with from M. oleifera is a major secondary metabolite compound. The seeds and leaves of the plant are reported to have the highest amount of glucosinolates. M. oleifera is well known for its many uses health and bene ts. It is claimed to have nutritional, medicinal and chemopreventive potentials. Chemopreventive effects of M. oleifera are expected due to the existence of glucosinolate which it is reported to have the ability to induce apoptosis in anticancer studies. Furthermore, chemopreventive value of M. oleifera has been demonstrated in studies utilizing its leaf extract to inhibit the growth of human cancer cell lines. This review highlights the advantages of M. oleifera targeting chemoprevention where glucosinolates could help to slow the process of carcinogenesis through several molecular targets. It is also includes inhibition of carcinogen activation and induction of carcinogen detoxi cation, anti-in ammatory, anti-tumor cell proliferation, induction of apoptosis and inhibition of tumor angiogenesis. Finally, for synergistic effects of M. oleifera with other drugs and safety, essential for chemoprevention, it is important that it safe to be consumed by human body and works well. Although there there were promising evident about M. oleifera in chemoprevention extensive research need to be done due to the expected rise of cancer in coming years and to gain more information about the mechanisms involved in M. oleifera in uence, which could be a good source to inhibit several major mechanisms involved in cancer development.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Cancer Registration in India - Current Scenario and Future Perspectives
3687
3696
33039
EN
Sharmila
Chatterjee
Center for Global Health and Development, University of Nebraska Medical Center College of Public Health, Omaha, NE, USA
Amit
Chattopadhyay
Surendra Nath
Senapati
Dipti Rani
Samanta
Leslie
Elliott
Dana
Loomis
Lesly
Mery
Journal Article
1970
01
01
Cancer registration, an important component of cancer surveillance, is essential to a uni ed, scienti c and public health approach to cancer prevention and control. India has one of the highest cancer incidence and mortality rates in the world. A good surveillance system in the form of cancer registries is important for planning and evaluating cancer-control activities. Cancer registration in India was initiated in 1964 and expanded since 1982, through initiation of the National Cancer Registry Program (NCRP) by the Indian Council of Medical Research. NCRP currently has twenty-six population based registries and seven hospital based registries. Yet, Indian cancer registries, mostly in urban areas, cover less than 15% of the population. Other potential concerns about some Indian registries include accuracy and detail of information on cancer diagnosis, and timeliness in updating the registry databases. It is also important that necessary data collection related quality assurance measures be undertaken rigorously by the registries to ensure reliable and valid information availability. This paper reviews the current status of cancer registration in India and discusses some of the important pitfalls and issues related to cancer registration. Cancer registration in India should be complemented with a nationwide effort to foster systematic investigations of cancer patterns and trends by states, regions and sub populations and allow a continuous cycle of measurement, communication and action.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Advances in Management of Hepatocellular Carcinoma
3697
3703
33040
EN
Pongphob
Intaraprasong
Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Sith
Siramolpiwat
Ratha-korn
Vilaichone
Journal Article
1970
01
01
Hepatocellular carcinoma (HCC) is the most frequent type of malignant liver tumor and a high impact health problem worldwide. The prevalence of HCC is particularly high in many Asian and African countries. Some HCC patients have no symptoms prior to diagnosis and many of them therefore present at late stage and have a grave prognosis. The well-established causes of HCC are chronic hepatitis B virus (HBV) or chronic hepatitis C virus (HCV) infection or alcoholic cirrhosis and nonalcoholic steatohepatitis. The Barcelona Clinic Liver Cancer (BCLC) Staging System remains the most widely used for HCC management guidelines. To date, the treatments for HCC are still very challenging for physicians due to limited resources in many parts of the world, but many options of management have been proposed, including hepatic resection, liver transplantation, ablative therapy, chemoembolization, sora nib and best supportive care. This review article describes the current evidence-based management of HCC with focus on early to advance stages that impact on patient overall survival.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Review of the Burden of Esophageal Cancer in Malaysia
3705
3709
33041
EN
Ab Hamid
Siti-Azrin
Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
0000-0002-8212-9849
Wan Adnan
Wan-Nor-Asyikeen
Bachok
Norsa'adah
Journal Article
1970
01
01
Esophageal cancer is one of the top leading causes of cancer-related deaths in Malaysia. To date, neither the prevalence nor incidence of esophageal cancer nationally have been recorded. Esophageal cancer remains a major and lethal health problem even if it is not common in Malaysia. The late presentation of esophageal cancer makes it a dif cult and challenging medical problem. Therefore, more governmental and non-governmental organizations of Malaysia should emphasize primary and secondary prevention strategies.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Survivin, a Promising Gene for Targeted Cancer Treatment
3711
3719
33042
EN
Fatemeh T
Shamsabadi
Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Mohammad Reza Akbari
Eidgahi
Parvaneh
Mehrbod
Nasibeh
Daneshvar
Zeenathul Nazariah
Allaudin
Ahad
Yamchi
Majid
Shahbazi
Journal Article
1970
01
01
Drawbacks of conventional cancer treatments, with lack of speci city and cytotoxicity using current approaches, underlies the necessity for development of a novel approach, gene-directed cancer therapy. This has provided novel technological opportunities in vitro and in vivo. This review focuses on a member of an apoptosis inhibitor family, survivin, as a valuable target. Not only the gene but also its promoter are applicable in this context. This article is based on a literature survey, with especial attention to RNA interference as well as tumor- speci c promoter action. The search engine and databases utilized were Science direct, PubMed, MEDLINE and Google. In addition to cell-cycle modulation, apoptosis inhibition, interaction in cell-signaling pathways, cancer-selective expression, survivin also may be considered as speci c target through its promoter as a novel treatment for cancer. Our purpose in writing this article was to create awareness in researchers, emphasizing relation of survivin gene expression to potential cancer treatment. The principal result and major conclusion of this manuscript are that survivin structure, biological functions and applications of RNA interference systems as well as tumor-speci c promoter activity are of major interest for cancer gene therapy.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Modifying Health Behavior for Liver Fluke and Cholangiocarcinoma Prevention with the Health Belief Model and Social Support Theory
3721
3725
33043
EN
Natnapa
Padchasuwan
Parasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima, Thailand
Soraya J
Kaewpitoon
Ratana
Rujirakul
Parichart
Wakkuwattapong
Jun
Norkaew
Jirawoot
Kujapun
Sukanya
Ponphimai
Wasugree
Chavenkun
Pontip
Kompor
Natthawut
Kaewpitoon
Journal Article
1970
01
01
The liver uke Opisthorchis viverrini is a serious health problem in Thailand. Infection is associated with cholangiocarcinoma (CCA), endemic among human populations in northeast and north Thailand where raw sh containing uke metacercariae are frequently consumed. Recently, Thailand public health authorities have been organized to reduce morbidity and mortality particularly in the northeast through O. viverrini and CCA screening projects. Health modi cation is one of activities included in this campaign, but systemic guidelines of modifying and developing health behavior among liver uke and CCA prevention in communities towards health belief and social support theory are still various and unclear. Here we review the guidelines for modifying and developing health behavior among populations in rural communities to strengthen understanding regarding perceived susceptibility, severity, bene ts, and barriers to liver uke and CCA prevention. This model may be useful for public health of cers and related organizations to further health behavior change in endemic areas.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Clinicopathologic Assessment of Ocular Adnexal Lymphoproliferative Lesions at a Tertiary Eye Hospital in Iran
3727
3731
33044
EN
Fahimeh
Asadi-Amoli
Department of pathology, Tehran University of Medical Sciences, Tehran, Iran
Zohreh
Nozarian
Hirbod Nasiri
Bonaki
Vahid
Mehrtash
Samaneh
Entezari
Journal Article
1970
01
01
Background The most common type of ocular lymphoma is nonHodgkin lymphoma (NHL) categorized into two groups indolent (slow growing) and aggressive (rapid growing) Differentiating benign reactive lymphoid hyperplasia (RLH) from malignant ocular adnexal lymphoma (OAL) is challenging Histopathology immunohistochemistry (IHC) and ow cytometry have been used as diagnostic tools in such cases Materials and Methods In this retrospective case series from 2002 to 2013 at Farabi Eye Center 110 patients with ocular lymphoproliferative disease were enrolled Prevalence anatomical locations mean age at diagnosis and the nal diagnosis of the disease with IHC were assessed. Comparison between previous pathologic diagnoses and results of IHC was made Immunoglobulin light chains and Bcell and Tcell markers and other immunophenotyping markers including CD20 CD3 CD5 CD23 CD10 CYCLIND1 and BCL2 were evaluated to determine the most accurate diagnosis The lymphomas were categorized based on revised EuropeanAmerican lymphoma (REAL) classi cation Results Mean ageSD (years) of the patients was 556 193 and 61 were male Patients with follicular lymphoma large Bcell lymphoma or chronic lymphocytic leukemiasmall cell lymphoma (CLLSLL) tended to be older Nine patients with previous diagnoses of low grade Bcell lymphoma were reevaluated by IHC and the new diagnoses were as follows extranodal marginal zone lymphoma(EMZL) (n1) SLL(n1) mantle cell lymphoma (MCL) (n3) reactive lymphoid hyperplasia RLH (n2) Two cases were excluded due to poor block Flowcytometry reports in these sevenpatients revealedSLL with positive CD5 and CD23 MCLwith positive CD5 and CyclinD1 and negative CD23 EMZL with negative CD5CD23 and CD10. One RLH patient wasnegative for KappaLambda and positive for CD3 and CD20 and the other was positive for all of the light chains CD3 and CD20 Orbit (491) conjunctiva (161) and lacrimal glands (161) were the most common sites of involvement Conclusions Accurate pathological classi cation of lesions is crucial to determine proper therapeutic approaches This can be achieved through precise histologic and IHC analyses by expert pathologists
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Possible Prognostic Role of HER2/Neu in Ductal Carcinoma In Situ and Atypical Ductal Proliferative Lesions of the Breast
3733
3736
33045
EN
Sahar Aly
Daoud
Pathology, faculty of medicine, Beni suef university, Beni Suef, Egypt
Wesam Maghawri
Ismail
Mohamed Salah
Abdelhamid
Tamer Mohamed
Nabil
Journal Article
1970
01
01
HER2/neu is a well-established prognostic and predictive factor for invasive breast cancer. However, the role of HER2/neu in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that it is mainly linked to in situ local recurrence. Although molecular data suggest that atypical ductal hyperplasia (ADH) and duct carcinoma in situ (DCIS) are related lesions, albeit with vastly different clinical implications, the role of HER2/neu expression in atypical ductal hyperplasia is not well de ned either. The aim of this study was to evaluate over expression of HER2/neu in DCIS and cases of ADH in comparison with invasive breast carcinoma. Archival primary breast carcinoma paraf n blocks (n15), DCIS only (n10) and ductal epithelial hyperplasia and other breast benign lesions (n25) were analyzed for HER2/neu immunoexpression. Follow up was available for 40% of the patients. HER2/neu was positive in 80%of both DCIS and invasive carcinoma, and 67% of atypical ductal hyperplasia (ADH) cases. Thus at least a subset of patients with preinvasive breast lesions were positive, which strongly suggests a role for Her2/neu in identifying high-risk patients for malignant transformation. Although these are preliminary data, which need further studies of gene ampli cation within these patients as well as a larger patient cohort with longer periods of follow up, they support the implementation of routine Her2/neu testing in patients diagnosed as pure DCIS and in orid ADH.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Lack of Any Role of Systemic In ammatory Responses in Predicting Muscle Invasion by Bladder Cancer
3737
3739
33046
EN
Mehmet
Solakhan
Medicalpark Gaziantep Hospital, Department of Urology, Gaziantep, Turkey
Ozlem
Demirpence
Nuri
Orhan
Omer Aydin
Yildirim
Ebru
Guzel
Mustafa
Yildirim
Journal Article
1970
01
01
Background The purpose of this study is to evaluate if there is a relation between platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) values and tumour histology and spread in bladder cancer cases. Materials and Methods Bladder cancer patients undergoing TUR-M operation, with histopathologically veri ed diagnosis, followed-up and treated at the Private Medical Park Gaziantep Hospital between 2010 and 2015, have were included in the study. NLR and PLR values were calculated using complete blood count data obtained at the rst presentation. Results A total of 99 patients were included in the study, 7 (7.1%) women and 92 men (92.9%). When NLR was used as the indicator of systemic in ammatory response (SIR), it was determined that, 52 (52.5%) of the patients were SIR negative and 47 (47.5%) SIR positive. No signi cant relation could be detected between NLR and tumour grade and muscle invasion (p0.948, p0.480). When PLR was used as SIR indicator, it was determined that 71 (71.7%) of the patients were found as negative and 28 (28.3%) as positive. No signi cant relation could be detected between PLR and tumour grade and muscle invasion (p0.651, p0.494). Conclusions In our study we did not detected a relation between tumour histological behavior and PLR and NLR in bladder cancer. However, NLR and PLR are easily calculated, accessible, inexpensive and simple-to-use laboratory data from whole blood counts.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Breast Cancer Risk Based on the Gail Model and its Predictors in Iranian Women
3741
3745
33047
EN
Mojgan
Mirghafourvand
Midwifery Department, Tabriz University of Medical Sciences, Tabriz, Iran
Sakineh
Mohammad-Alizadeh-Charandabi
Parivash
Ahmadpour
Pari
Rahi
Journal Article
1970
01
01
Background This study was carried out to examine breast cancer risk and its fertility predictors in women aged 35. Materials and Methods This cross-sectional study was conducted on 560 healthy women referred to health centers of Tabriz-Iran, 2013-2014. Five-year and lifetime risk of developing breast cancer were determined using the Gail model. General linear modeling was applied to determine breast cancer predictors. Results The mean age of the subjects was 42.7 (SD 7.7) years. Mean 5-year and lifetime risks of developing breast cancer were determined to be 0.6% (SD 0.2%) and 8.9% (SD 2.5%), respectively. Variables of family history of breast cancer, age, age at menarche, parity, age at rst childbirth, breastfeeding history, frequency of breastfeeding, method of contraception, marital status and education were all found to be predictors of breast cancer risk. Conclusions According to the results of this study, screening programs based on the Gail model should be implemented for Iranian people who have a high risk for breast cancer in order to facilitate early detection and better plan for possible malignancies.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Sexual Dysfunction in Patients with Polycystic Ovary Syndrome in Malaysia
3747
3751
33048
EN
Sareh
Dashti
Department of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia
Latiffah A
Latiff
Habibah Abdul
Hamid
Suriani Mohamad
Sani
Mehrnoosh
Akhtari-Zavare
Azrin Shah
Abu Bakar
Nur Amirah Inani
Binti Sabri
Maimunah
Ismail
Ali Jafarzadeh
Esfehani
Journal Article
1970
01
01
Background Polycystic ovary syndrome (PCOS) is a combination of chronic anovulation, obesity, and hyperandrogenism and can affect sexual function in women of reproductive age. It is also associated with endometrial cancer. Our aim was to evaluate the frequency and predisposing factors of sexual dysfunction in PCOS patients. Materials and Methods In this cross-sectional study, 16 married women with a de nite diagnosis of PCOS were recruited. Sexual function was assessed in the domains of desire, arousal, lubrication, orgasm, satisfaction and pain using the female sexual function index (FSFI) questionnaire. Patients were also assessed for mental health using the depression, anxiety and stress (DASS-21) questionnaire. Presence of hirsutism was assessed using the Ferriman-Gallwey (FG) scoring system. Demographic data were obtained from patients during in-person interview. Results Sexual dysfunction was present in 62.5% of patients with the domains of arousal and lubrication particularly affected (93.8% and 87.5%, respectively). Patients with symptoms of depression and anxiety were signi cantly more likely to suffer sexual dysfunction than those without these symptoms (p0.04 and p0.03 respectively). Patients with stress symptoms reported higher orgasm dysfunction than those without (p0.02). No signi cant difference in any of the FSFI score domains was observed between patients with and without hirsutism. Conclusions PCOS patients markedly suffer from sexual dysfunction and therefore it seems appropriate to be screened for intervention. Poor mental health conditions that may be the result of infertility or other complications of PCOS should also be considered as curable causes of sexual dysfunction in these patients.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Potential Role of Electrochemotherapy as Anticancer Treatment for Cutaneous and Subcutaneous Lesions
3753
3757
33049
EN
Anna
Zygogianni
Department of Radiology, Radiotherapy Unit, Aretaieion University Hospital, Medical School, Kapodistrian University of Athens, Greece
George
Kyrgias
John
Scarlatos
Michael
Koukourakis
Kyriakos
Souliotis
John
Kouvaris
Nikolaos
Kelekis
Vassilis
Kouloulias
Journal Article
1970
01
01
Background The aim of this study was to investigate whether electrochemotherapy is a clinically and cost- effective treatment option against skin tumors. Materials and Methods We performed an analysis of the current literature based on database searches in PubMed/MEDLINE and we included articles till July 2012. Terms used for the search were 'electrochemotherapy', 'skin cancer', 'recurrence', and 'cutaneous and subcutaneous tumors'. Only papers published in English were included. In addition, we performed an analysis of the cost effectiveness of the method. Results The combination of physics and chemistry is the foundation for electrochemotherapy and its ef cacy, independent of the tumor histology. Clinical data showed that ECT is well tolerated and can be used in dif cult cases without other available treatment options. The analysis also showed that the treatment is feasible and cost-effective. Conclusions Electrochemotherapy is a clinically ef cient safe and cost-effective treatment and clinicians should not hesitate to use it as alternative therapeutic modality or as palliative treatment.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Assessing Breast Cancer Risk among Iranian Women Using the Gail Model
3759
3762
33050
EN
Maryam
Khazaee-Pool
Department of Health Education and Promotion, School of Health, Zanjan University of Medical Sciences, Zanjan, Iran
Fereshteh
Majlessi
Saharnaz
Nedjat
Ali
Montazeri
0000-0002-5198-9539
Leila
Janani
Tahereh
Pashaei
Journal Article
1970
01
01
Background Breast cancer risk assessment is a helpful method for estimating development of breast cancer at the population level. Materials and Methods: In this cross-sectional study, participants consisted of a group of 3,847 volunteers (mean SD age 463 7.59 years) in a convenience sample of women referred to health centers af liated to Tehran University of Medical Sciences in Tehran, Iran. The risk of breast cancer was estimated by applying the National Cancer Institute's online version of the Gail Risk Assessment Tool. Results Some 24.9% of women reported having one rst-degree female relative with breast cancer, with 8.05% of them having two or more rst-degree relatives with breast cancer. The mean ve-year risk of breast cancer for all participants was 1.610.73%, and 9.36% of them had a ve-year risk of breast cancer >1.66%. The mean lifetime risk of breast cancer was 11.73.91%. Conclusions The Gail model is useful for assessing probability of breast cancer in Iranian women. Based on the their breast cancer risk, women may decide to accept further screening services.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Determinants of Cervical Cancer Screening Uptake in Kurdish Women Living in Western Iran, 2014
3763
3767
33051
EN
N
Aminisani
Epidemiology and Statistics Department, Faculty of Health Sciences, Tabriz University of Medical Siences, Tabriz, Iran
0000-0001-9786-4419
R
Fattahpour
L
Abedi
SM
Shamshirgaran
Journal Article
1970
01
01
Background Cervical cancer is the second most common cancer among females across the world. It is a preventable cancer and early detection is very feasible. This study aimed to identify which women characteristics are potentially associated with and may have an important in uence on the uptake of cervical cancer screening in Kurdish women living in the west of Iran.. Materials and Methods A cross sectional study was conducted in late 2014. A random sample of women aged 40 years and above without history of cervical cancer and identi ed as Kurdish background were selected and interviewed by two trained interviewers. Information about sociodemographic and reproductive factors, history of diseases, and cervical screening was collected using a questionnaire and women who had undergone a hysterectomy were excluded. Univariate analyses were used to describe the general characteristics of the study population. Multivariable logistic regression models with self-reported screening history were used to estimate odds ratios (ORs) with 95% con dence intervals (CI). Signi cance was considered at the 5% level. Results A total of 561 women were included in this study (mean age 43.65.17 years) participation in cervical screening at least once was about 32%. Cervical screening uptake percentage was signi cantly lower among people over 60 years of age (adjusted OR 0.26, 95% CI 0.11-0.64), and those who were illiterate (OR0.41 95% CI 0.23-0.73) and post-menopausal (OR 0.56, 95% CI 0.35- 0.91). Women with 1 child were less likely to report a Pap test (adjusted OR.43 95%CI 0.13-1.37) Cervical screening uptake was higher among women with health insurance (OR 2.31, 95% CI 1.50- 3.56). Conclusions Cervical screening participation in this study was low compared to other studies in developed countries. The screening uptake was different based on age, education, parity, insurance coverage and menopausal status. It is recommended to target these groups of women in cervical screening program.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Assessment of Breast Cancer Knowledge among Health Workers in Bangui, Central African Republic a Cross-sectional study
3769
3776
33052
EN
Augustin
Balekouzou
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Sciences and Technology, Wuhan, China
Ping
Yin
Christian Maucler
Pamatika
Sylvain Wilfrid
Nambei
Marceline
Djeintote
Eric
Doromandji
Andre Richard
Gouaye
Pascal Gastien
Yamba
Elysee Ephraim
Guessy
Bertrand
Ba-Mpoutou
Dieubeni Rawago
Mandjiza
Chang
Shu
Minghui
Yin
Zhen
Fu
Tingting
Qing
Mingming
Yan
Grace
Mella
Boniface
Koffi
Journal Article
1970
01
01
Background Breast cancer is the leading cause of cancer deaths among women worldwide. High breast cancer mortality has been attributed to lack of public awareness of the disease. Little is known about the level of knowledge of breast cancer in Central African Republic. This study aimed to investigate the knowledge of health professionals on breast cancer. Materials and Methods This cross-sectional study was conducted among 158 health professionals (27 medical; 131 paramedical) in 17 hospitals in Bangui using a self-administered questionnaire. Descriptive statistical analysis, Person's 2 test and ANOVA were applied to examine associations between variables with
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Lack of Any Relationship of Stomach Cancer Incidence and Mortality with Development in Asia
3777
3783
33053
EN
Elahe
RaFiei
Epidemiologist, Guilan University of Medical Sciences, Rasht, Guilan, Iran
0000-0001-7642-5214
Abdollah
Mohammadian-Hafshejani
Farhad
Towhidi
Behnam Reza
Makhsosi
Hamid
Salehiniya
Journal Article
1970
01
01
Background The aim of this study was to evaluate the incidence and mortality of stomach cancer, and its relationship with the Human Development Index (HDI) and its components in Asia in 2012. Materials and Methods This ecological study wa conducted based on GLOBOCAN project of WHO for Asian countries. We assessed the correlations between standardized incidence rates (SIR) and standardized mortality rates (SMR) of stomach Cancer with HDI and its components using SPSS18. Results A total of 696,231 cases (68.7% in males and 31.3% in females, ratio of 2.191) and 524,465 deaths (67.1% in men and 33.0% in women, ratio 2.031) were included in 2012. Five countries with the highest SIR of stomach cancer were Republic Korea, Mongolia, Japan, China and Tajikistan. Five countries with the highest SMR of stomach cancer were Mongolia, Tajikistan, Kyrgyzstan, Kazakhstan and China. Correlation between HDI and SIR was 0.241 (p 0.106), in men 0.236 (p 0.114) and in women -0.250 (p 0.094). Also between HDI and SMR -0.250 (p 0.871) in men -0.018 (p 0.903) and in women -0.014 (p 0.927). Conclusions No signi cant correlation was observed between the SIR of stomach cancer, and the HDI and its dimensions, such as life expectancy at birth, mean years of schooling, and income level of the population.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Association of Cytotoxic T-lymphocyte Antigen-4 Polymorphisms with Malignant Bone Tumors Risk A Meta-analysis
3785
3791
33054
EN
Chao
Zhang
Department of orthopaedics, The First Hospital of Lanzhou University, Lanzhou, China
Wei-Hua
Hou
Xuan-Xi
Ding
Xiong
Wang
Hui
Zhao
Xing-Wen
Han
Wen-Ji
Wang
Journal Article
1970
01
01
Background Previous studies have assessed the association between the Cytotoxic T-lymphocyte Antigen- 4(CTLA-4) polymorphism with the risk of malignant bone tumor, but the conclusions were inconsistent. We aimed to clarify association of cytotoxic T-lymphocyte antigen-4 polymorphisms with malignant bone tumors risk by performing a meta-analysis. Materials and Methods The databases including PubMed, EMBase databases and the Cochrane Library were searched to identify the eligible studies prior to January 30 2016. Odds ratio (OR) with 95% con dence interval (95%CI) were used to estimate the strengths of the association between the CTLA-4 polymorphism and the malignant bone tumor risks. The meta-analysis was performed by STATA 12.0. Results Four individual studies with a total of 1003 cases with malignant bone tumor and 1162 controls were included in our meta-analysis. The results of meta-analysis on those data demonstrated that CTLA-4 +49G>A polymorphism was associated with the risk of Ewing's sarcoma and osteosarcoma strongly (A vs. G OR1.36, 95%CI1.20- 1.54, p0.000; AA+AG vs. GG OR1.35, 95%CI1.14-1.61, p0.001; AA vs. GG OR2.24, 95%CI1.67-2.99, p0.000; AA vs. AG+GG OR2.00, 95%CI1.53-2.62, p0.000), but CTLA-4 -318C/T polymorphism was not associated with the risk of malignant bone tumor (C vs. T OR0.76, 95%CI0.76-1.08, p 0.262; CC+CT vs. TT OR0.70, 95%CI0.41-1.20, p0.198; CC vs. TT OR0.69, 95%CI0.40-1.19, p 0.183; CC vs. CT+TT OR0.92, 95%CI0.75-1.13, p 0.419). Subgroup analysis showed that there are signi cantly positive correlations between CTLA-4 +49G>A polymorphism and increased risks of malignant bone tumors in large size of sample (A vs. G OR1.347, 95%CI 1.172,1.548, p0.000; AA vs. GG OR2.228, 95%CI 1.608,3.085, p0.000), Ewing's Sarcoma or Osteosarcoma (A vs. G OR1.361, 95%CI 1.201,1.540, p0.000; AA vs. GG OR2.236, 95%CI 1.674,2.986, p0.000), and PCR-RFLP or Sequencing(A vs. G OR1.361, 95%CI 1.201,1.540, p0.000; AA vs. GG OR2.236, 95%CI 1.674,2.986, p0.000), but CTLA-4 -318C/T polymorphism was not associated with the risk of malignant bone tumors in diagnosis, genotype method, and sample size (all p>0.05). Conclusions CTLA-4 +49A/G variant was associated with an increased risk of developing the malignant bone tumors, such as Ewing's sarcoma and osteosarcoma. However, it failed to show the association between CTLA-4 -318C/T polymorphism and the risk of malignant bone tumors. Future large-scale studies remain to be done to con rm our conclusions.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Global Prostate Cancer Incidence and Mortality Rates According to the Human Development Index
3793
3796
33055
EN
Salman
Khazaei
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Shahab
Rezaeian
Erfan
Ayubi
Behzad
Gholamaliee
Mahin Ahmadi
Pishkuhi
Somayeh
Khazaei
Kamyar
Mansori
Shahrzad
Nematollahi
Mohadeseh
Sani
Shiva Mansouri
Hanis
Journal Article
1970
01
01
Background Prostate cancer (PC) is one of the leading causes of death, especially in developed countries. The human development index (HDI) and its dimensions seem correlated with incidence and mortality rates of PC. This study aimed to assess the association of the speci c components of HDI (life expectancy at birth, education, gross national income per 1000 capita, health, and living standards) with burden indicators of PC worldwide. Materials and Methods Information of the incidence and mortality rates of PC was obtained from the GLOBOCAN cancer project in year 2012 and data about the HDI 2013 were obtained from the World Bank database. The correlation between incidence, mortality rates, and the HDI parameters were assessed using STATA software. Results A signi cant inequality of PC incidence rates was observed according to concentration indexes0.25 with 95% CI (0.22, 0.34) and a negative mortality concentration index of -0.04 with 95% CI (-0.09, 0.01) was observed. Conclusions A positive signi cant correlation was detected between the incidence rates of PC and the HDI and its dimensions including life expectancy at birth, education, income, urbanization level and obesity. However, there was a negative signi cant correlation between the standardized mortality rates and the life expectancy, income and HDI.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Puri cation of Lovastatin from Aspergillus terreus (KM017963) and Evaluation of its Anticancer and Antioxidant Properties
3797
3803
33056
EN
SD
Bhargavi
Department of Microbiology and Biotechnology, Bangalore University, Bangalore, India
VK
Praveen
Salah
Marium
M
Sreepriya
J
Savitha
Journal Article
1970
01
01
Cervical cancer is the second most common malignancy in women worldwide and thus one of the leading causes of mortality in women. Lovastatin, a non polar, anticholesterol drug has previously been reported to exert antitumour activity in vitro. In the present study, lovastatin from Aspergillus terreus (KM017963) was puri ed by adsoprtion chromatography and evaluated for its anticancer and anti-oxidant properties with a human cervical cancer cell line (HeLa). Growth inhibitory and proapoptotic effects of puri ed lovastatin on HeLa cells were investigated by determining its in uence on cell numbers, mitochondrial membrane potential (MMP), DNA fragmentation and antioxidant properties in terms of hydroxy radical scavenging effects as well as levels of total reduced glutathione. Cell cycle analysis by ow cytometry (propidium iodide staining) con rmed induction of apoptotic cell death and revealed cell cycle arrest in the G0/G1 phase. Results of the study give leads for the anticancer effects of lovastatin and its potential usefulness in the chemotherapy of cervical cancer.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Chronic Infections of the Urinary Tract and Bladder Cancer Risk a Systematic Review
3805
3807
33057
EN
Oghenetejiri
Anderson-Otunu
Department of Public Health, Faculty of Health, Social Care and Education, Anglia Ruskin University, Cambridge, United Kingdom
Saeed
Akhtar
Journal Article
1970
01
01
Literature on the relationship between recurrent urinary tract infections and urinary bladder carcinoma risk has been inconsistent. Therefore, we carried out this systematic review of observational studies to ascertain if there is any association between chronic urinary tract infection and urinary bladder carcinoma. A total of 10 databases were searched using Boolean CINAHL, PUBMED, Google Scholar, Medline, Science Direct, SCIRUS, Cochrane, UK PubMed central, NHS evidence and WHO-website. The search yielded an initial hit of 3,518 articles and after screening and critical appraisal, seven studies were included for this review. Four articles reported an association between chronic urinary tract infections and bladder cancer while three concluded a weak or no association at least in one gender. Main ndings in this review were that most of the studies reported an association between chronic urinary tract infections and bladder cancer risk. However, inferences about the causal association between chronic urinary tract infections and bladder cancer risk should be drawn cautiously considering the methodological limitations of case-control studies included in this review. Therefore, more empirical evidence is needed to determine the causal nature of relationships between chronic urinary tract infections and bladder cancer risk.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Cancer Screening Knowledge and Attitudes of Under- and Post-Graduate Students at Kasr Al Ainy School of Medicine, Cairo University, Egypt
3809
3816
33058
EN
Amal Samir
Sedrak
Department of Community Medicine and Public Health, Faculty of Medicine, Cairo University, Cairo, Egypt
Yasmine Samir
Galal
Tarek Tawfik
Amin
Journal Article
1970
01
01
Background Increasing knowledge and awareness of cancer screening signi cantly in uence health promotion behavior which could markedly reduce incidence rates. In many countries, health care providers are the principal source of information concerning cancer screening. This study was carried out to assess the level of knowledge concerning cancer screening among medical students, house of cers and residents and to explore their attitude towards cancer screening practices. Materials and Methods This cross-sectional study was conducted in Kasr Al Ainy Medical School at Cairo University in Egypt, with 300 undergraduate medical students and 150 postgraduates (interns and residents) enrolled. A pre-tested self-administered questionnaire was used to collect data from the study participants regarding personal and education-related information, knowledge about cancer screening and its sources, and attitude towards cancer screening. Results More than 64% of participants had knowledge scores of 10 points (out of 24). The total knowledge score (out of 6 points) for breast cancer screening increased from 1.91.0 to 2.31.2 and 2.41.1 for 4th, 5th and 6th year respectively, interns showed the highest score of 2.6 1.1, P 0.001. Year of enrollment at medical school was a signi cant positive predictor of acquiring knowledge about cancer screening (post graduate vs. undergraduate students) (OR 1.30, C.I 1.01-1.63), lack of or none receiving of orientation/training about cancer screening was the sole negative signi cant predictor for proper knowledge about cancer screening (OR0.50, C.I0.31-0.82). Over 92% of students agreed that they had insuf cient knowledge about cancer screening, 88.2% appraised the need to have enough knowledge in order to direct/advice patients, relatives and friends, and 93.7% required that the faculty should emphasize the importance of cancer screening in the delivered curricula at medical school. Conclusions: A relatively low to moderate level of knowledge about cancer screening was detected among the selected medical students regardless of their year of enrollment at medical school or their graduation status, which may implicate a negative impact on early cancer detection especially in a low resource country like Egypt.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Clinicopathological Characteristics of Iranian Patients with Lung Cancer a Single Institute Experience
3817
3822
33059
EN
Khosravi
Adnan
Medical Oncology, Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Esfahani-Monfared
Zahra
Sei
Sharareh
Karimi
Shirin
Emami
Habib
Khodadad
Kian
Journal Article
1970
01
01
Background Lung cancer has long been a leading cause of cancer related death in both women and men worldwide. The focus of this study was to review clinicopathological features of Iranian patients diagnosed with lung cancer. Materials and Methods Clinicopathological data of 1353 primary lung cancer patients diagnosed during 17 years (1997-2014) in the National Institute of Tuberculosis and Lung Disease (NRITLD), Tehran, Iran, were retrospectively reviewed. Results The median age of patients was 60 (mean 58.95 years, range 16- 99) and adenocarcinoma was the most prevalent pathology (45.2%). Male/female ratio was 3.22 and 57.2% of patients were smokers (men 70.3%, women 15%). The majority (85.3%) were referred in advanced stages (stage IIIB and IV). Conclusions Although some of our ndings are in concordance with other studies in lung cancer but there are some discrepancies particularly in terms of smoking status and median age of Iranian patients. Further clinical and epidemiological studies are warranted to elucidate etiologic and factors other than smoking contributing to development of lung cancer such as environmental exposures or genetic predisposition.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
The Association of Circumcision and Prostate Cancer A Meta-Analysis
3823
3827
33060
EN
Yu-dan
Li
Key laboratory of diseases of urological system Gansu Province, Gansu Nephro-Urological Clinical Center, The Second Hospital of Lanzhou University, Lanzhou, China
Yang
Teng
Yu
Dai
Hui
Ding
Journal Article
1970
01
01
Background To investigate the association circumcision with prostate cancer. Materials and Methods We searched PubMed, EMBASE, the Cochrane Library, and Chinese biomedicine literature database up to August 2015. All case-control studies were identi ed in which investigated the association circumcision with prostate cancer. Three authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.3 and STATA version 11.0. Results Six case-control studies met the inclusion criteria. The pooled meta-analysis showed that there was a lower incidence of circumcision in prostate cancer patients compared with control (OR0.90, 95% con dence interval [CI] 0.82-0.98, P0.01). The results of meta-analysis also showed that no signi cant difference was found between circumcision and less aggressive prostate cancer (OR0.93, 95% CI 0.83-1.04, P0.19); however, there was a lower incidence of circumcision in more aggressive prostate cancer compared with control (OR 0.84, 95% CI 0.72-0.97, P0.02). The Egger's results did not show any evidence of publication bias(P0.798). Conclusions In summary, within the limits of available data, male with circumcision appears to have a lower incidence of prostate cancer. In the future, high-quality multicenter studies are needed to thoroughly verify the outcome.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Polysaccharide from Polygonatum Inhibits the Proliferation of Prostate Cancer-Associated Fibroblasts Cells
3829
3833
33061
EN
Shu-Yu
Han
Institute of Biophysics, Chinese Academy of Science, Beijing, China
Ming-Hua
Hu
Guan-Yun
Qi
Chao-Xiong
Ma
Yuan-Yuan
Wang
Fang-Li
Ma
Ning
Tao
Zhi-Hai
Qin
Journal Article
1970
01
01
<span style="font-size: small;">Inhibition of cancer-associated fibroblasts (CAFs) may improve the efficacy of cancer therapy. Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (p<0.001) without inhibiting the growth of normal fibroblasts (NAFs). Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs. 3-methyl-adenine(3-MA) is an autophagy inhibitor. 3-MA was added to prostate-CAFs with polysaccharide from polygonatum to determine whether autophagy plays an important role in the restrained effect. Finally, polysaccharide from polygonatum treatment signi</span><span style="font-size: small;">ficantly increased the activation of Beclin-1 and LC3, key autophagy proteins. Polysaccharide from polygonatum stimulates autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate- CAFs. </span>
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Preparation, Characterization and Cytotoxicity of Silibinin- Containing Nanoniosomes in T47D Human Breast Carcinoma Cells
3835
3838
33062
EN
Boshra
Amiri
Chemistry faculty, Islamic Azad University of Shahrood, Semnan, Iran
0000-0001-6413-8752
Meysam
Ebrahimi-Far
Zahra
Saffari
Azim
Akbarzadeh
Esmaeil
Soleimani
Mohsen
Chiani
Journal Article
1970
01
01
Background Breast cancer is one of the most frequent cancer types within female populations. Silibinin is a chemotherapeutic agent ative against cancer. Niosomes are biodegradable, biocompatible, safe and effective carriers for drug delivery. ObjectiveTo prepare nanoniosomal silibinin and evaluate its cytotoxicity inthe T-47D breast cancer cell line. Materials and Methods Niosomes were prepared by reverse phase evaporation of a mixture of span 20, silibinin, PEG-2000 and cholesterol in chloroform and methanol solvent (12 v/v). The solvent phase was evaporated using a rotary evaporator and the remaining gel phase was hydrated in phosphate buffer saline. Mean size, size distribution and zeta potential of niosomes were measured with a Zetasizer instrument and then nanoparticles underwent scanning electron microscopy. The drug releasing pattern was evaluated by dialysis and the cytotoxicity of nanoniosomes in T-47D cells was assessed by MTT assay. Results Particle size, size variation and zeta potential of the niosomal nanoparticles were measured as 178.4 5.4 nm, 0.38 0.09 and -15.3 1.3 mV, respectively. The amount of encapsulated drug and the level of drug loading were determined 98.6 2.7% and 22.3 1.8%, respectively; released drug was estimated about 18.62.5% after 37 hours. The cytotoxic effects of nanoniosome were signi cantly increased when compared with the free drug. Conclusions This study nding suggests that silibinin nanoniosomes could serve as a new drug formulation for breast cancer therapy.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Prevalence of Cigarette Smoking Usage among Adolescent Students in Northern Saudi Arabia
3839
3843
33063
EN
Rakan Mosa
Algorinees
College of Medicine, University of Hail, Kingdom of Saudi Arabia (KSA)
Ibrahim Ghazy Kiran
Alreshidi
Mohammed Fahad Mohammed
Alateeq
Abdullah Abdulaziz Salem
Alghuraymi
Adel Ahmed Abdulrahman
Alfayez
Fahad Khaled Fahad
Almuzaini
Mohammed Abdulaziz Brahim
Alsaif
Journal Article
1970
01
01
Background Cigarette smoking is a major public health issue in the Kingdom of Saudi Arabia (KSA) in recent years, particularly among adolescents. Therefore, the aim of this study was to determine the prevalence of cigarette smoking usage among adolescent students in the north of the country. Materials and Methods This was a cross-sectional study investigated 305 adolescent students from the Northern KSA population, their ages ranging from 11 to 19 years old. Results Of the 287 respondents, 56/287(19.5%) were found to be current smokers. Of the 56 current smokers, 14/52 (27%), 29/52 (55.8%), and 9/52 (17.2%) smoked 1-3, 4-10 and 11+ cigarettes/day, respectively. For duration most had smoked for 26-36 months. Conclusions The findings of the present study indicate that cigarette smoking use is still an important risk behavior among adolescent students. The findings of this study found a significant association of cigarette smoking usage and adolescents various believes and attitude for initiation of smoking and perception toward knowledge of other factors that contribute to the burden of tobacco use.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Subsequent Oophorectomy and Ovarian Cancer after Hysterectomy for Benign Gynecologic Conditions at Chiang Mai University Hospital
3845
3848
33064
EN
Aurapin
Jitkunnatumkul
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Charuwan
Tantipalakorn
Kittipat
Charoenkwan
Jatupol
Srisomboon
Journal Article
1970
01
01
This study was undertaken to determine the incidence of subsequent oophorectomy due to ovarian pathology or ovarian cancer in women with prior hysterectomy for benign gynecologic conditions at Chiang Mai University Hospital. Medical records of women who underwent hysterectomy for benign gynecologic diseases and pre- cancerous lesions between January 1, 2004 and December 31, 2013 at Chiang Mai University Hospital were retrospectively reviewed. The incidence and indications of oophorectomy following hysterectomy were analyzed. During the study period, 1,035 women had hysterectomy for benign gynecologic conditions. Of these, 590 women underwent hysterectomy with bilateral salpingo-oophorectomy and 445 hysterectomy with bilateral ovarian preservation or unilateral salpingo-oophorectomy. The median age was 47 years (range, 11-75 years). Ten women (2.45 %) had subsequent oophorectomy for benign ovarian cysts. No case of ovarian cancer was found. The mean time interval between hysterectomy and subsequent oophorectomy was 43.1 months (range, 2-97 months) and the mean follow-up time for this patient cohort was 51 months (range, 1.3-124.9 months). According to our hospital-based data, the incidence of subsequent oophorectomy in women with prior hysterectomy for benign gynecologic conditions is low and all represent benign conditions.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Effects of Breast Self-Examination Consultation Based on the Health Belief Model on Knowledge and Performance of Iranian Women Aged Over 40 Years
3849
3854
33065
EN
Parisa
Parsa
Research Center for Chronic Diseases Home care, Mother and Child Health, Hamadan University of Medicine and Health Sciences, Hamadan, Iran
0000-0002-2834-2470
Ameneh
Mirmohammadi
Batoul
Khodakarami
Godratalah
Roshanaiee
Farzaneh
Soltani
Journal Article
1970
01
01
Background Breast cancer is the most prevalent malignancy in women worldwide; lack of awareness of symptoms and delay on diagnosis of breast cancer are the main causes of mortality among women. This study was conducted with the purpose of assessing the effect of educational consulting for breast self-examination (BSE) based on the health belief model (HBM) on the knowledge and performance of women over 40 years attending health care centers in Hamadan, Iran. Materials and Methods In this quasi-experimental study, eligible women admitted to health centers in Hamadan city in 2015 were randomly assigned to intervention and control groups (n75 in each group). The intervention group received 4 weekly sessions of breast cancer screening consulting based on the HBM. Control group received only routine care. Knowledge, HBM constructs, and BSE practice were compared between the groups before, immediately after and three months after the consultation. Results Before the intervention, no significant differences were observed in knowledge, health belief and practice between two groups. However, after the intervention a significant difference was observed between two groups in mean scores of perceived benefits, perceived barriers, self-efficacy and the health motivations (<0.05). Significant differences were also observed in terms of knowledge and BSE practice (<.01). Conclusions The results indicate the importance of consultation on knowledge and beliefs to improve BSE performance and prevention of breast cancer in Iranian women.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Glutathione S-transferase T1, M1 and P1 Genetic Polymorphisms and Susceptibility to Colorectal Cancer in Turkey
3855
3859
33066
EN
Ozlem
Gorukmez
Uludag University, School of Medicine, Department of Medical Genetics, Bursa, Turkey
Tahsin
Yakut
Orhan
Gorukmez
Ali
Topak
Serdar
Sahinturk
Ozkan
Kanat
Journal Article
1970
01
01
Colorectal cancer (CRC) is reproted to be the third most common cancer worldwide and the fourth most common cause of cancer related deaths. CRC is considered to be a multifactorial disease whose risk varies due to the complex interaction between individual genetic basis and disposure to multiple endogenous factors. Glutathione S-transferases are pro-carcinogenic in CRC and are required for the conjugation between chemotherapeutics and broad spectrum xenobiotics. One hundred and eleven patients with CRC and 128 control subjects without any cancer history were enrolled in this study. Multiplex PCR was applied to determine polymorphisms for the GSTT1 and M1 genes, and PCR-RFLP was applied for the GSTP1 (Ile105Val) gene polymorphism. Values
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Lack of Association between Serum Adiponectin/Leptin Levels and Medullary Thyroid Cancer
3861
3864
33067
EN
Raziyeh
Abooshahab
Department of Biology, Faculty of Basic Sciences, Science Research Campus of Islamic Azad University, Tehran, Iran
Parichehr
Yaghmaei
Hoda Gholab
Ghadaksaz
Mehdi
Hedayati
Journal Article
1970
01
01
Background Adipokines are bioactive proteins that mediate metabolism, in ammation and angiogenesis. Changes in the secretion of key serum adipokines - adiponectin and letpin - may be associated with obesity, cancer and metabolic disorders. Thyroid cancer is one of the most important types of endocrine cancer. Therefore, investigating the association between serum levels of adiponectin and leptin and thyroid cancer might be important. The purpose of this study was to assess adiponectin and leptin levels in medullary thyroid carcinoma (MTC) cases in order to identify novel tumor markers. Materials and Methods This research was based on a case-control study, including 45 patients with medullary thyroid cancer (21 men and 24 women) and 45 healthy controls (24 males and 21 females). Adiponectin and leptin levels were measured by ELISA in both groups. Height and weight were measured and body mass index (kg/m2) was calculated. Results Adiponectin and leptin levels were not signi cantly different between medullary thyroid carcinomas and the control group. Also, there was no correlation among age and body mass index and the disease. Conclusions These results suggest that changes in serum adiponectin and leptin levels do not play an important role in the diagnosis or could act as as biomarkers for medullary thyroid cancer.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage
3865
3869
33068
EN
Deepshikha
Mishra
Department of Molecular and Human Genetics, Mahila Mahavidyalaya, Varanasi, India
Sunita
Singh
Gopeshwar
Narayan
Journal Article
1970
01
01
Curcumin, a polyphenolic compound isolated from the rhizomes of an herbaceous perennial plant, Curcuma longa, is known to possess anticancerous activity. However, the mechanism of apoptosis induction in cancers differs. In this study, we have (1) investigated the anticancerous activity of curcumin on REH and RS4;11 leukemia cells and (2) studied the chemo-sensitizing potential of curcumin for doxorubicin, a drug presently used for leukemia treatment. It was found that curcumin induced a dose dependent decrease in cell viability because of apoptosis induction as visualized by annexin V-FITC/ PI staining. Curcumin-induced apoptosis of leukemia cells was mediated by PARP-1 cleavage. An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment. In addition, curcumin at doses lower than the IC50 value signi cantly enhanced doxorubicin induced cell death. Therefore, we conclude that curcumin induces apoptosis in leukemia cells via PARP-1 mediated caspase-3 dependent pathway and further may act as a potential chemo-sensitizing agent for doxorubicin. Our study highlights the chemo-preventive and chemo-sensitizing role of curcumin.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
The Offer of Advanced Imaging Techniques Leads to Higher Acceptance Rates for Screening Colonoscopy - a Prospective Study
3871
3875
33069
EN
Heinz
Albrecht
Department of Medicine, University of Erlangen-Nuremberg, Erlangen, Germany
Julia
Gallitz
Robert
Hable
Michael
Vieth
Gian Eugenio
Tontini
Markus Friedrich
Neurath
Jurgen Ferdinand
Riemann
Helmut
Neumann
Journal Article
1970
01
01
Background Colonoscopy plays a fundamental role in early diagnosis and management of colorectal cancer and requires public and professional acceptance to ensure the ongoing success of screening programs. The aim of the study was to prospectively assess whether patient acceptance rates to undergo screening colonoscopy could be improved by the offer of advanced imaging techniques. Materials and Methods Overall, 372 randomly selected patients were prospectively included. A standardized questionnaire was developed that inquired of the patients their knowledge regarding advanced imaging techniques. Second, several media campaigns and information events were organized reporting about advanced imaging techniques, followed by repeated evaluation. After one year the evaluation ended. Results At baseline, 64% of the patients declared that they had no knowledge about new endoscopic methods. After twelve months the overall grade of information increased signi cantly from 14% at baseline to 34%. The percentage of patients who decided to undergo colonoscopy because of the offer of new imaging methods also increased signi cantly from 12% at baseline to 42% after 12 months. Conclusions Patients were highly interested in the offer of advanced imaging techniques. Knowledge about these techniques could relatively easy be provided using local media campaigns. The offer of advanced imaging techniques leads to higher acceptance rates for screening colonoscopies.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Ef cacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy
3877
3880
33070
EN
Mansour
Ansari
Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
0000-0002-7423-3312
Pezhman
Porouhan
Mohammad
Mohammadianpanah
Shapour
Omidvari
0000-0001-9391-8977
Ahmad
Mosalaei
Niloofar
Ahmadloo
Hamid
Nasrollahi
Seyed Hasan
Hamedi
Journal Article
1970
01
01
Nausea and vomiting are among the most serious side effects of chemotherapy, in some cases leading to treatment interruption or chemotherapy dose reduction. Ginger has long been known as an antiemetic drug, used for conditions such as motion sickness, nausea-vomiting in pregnancy, and post-operation side effects. One hundred and fifty female patients with breast cancer entered this prospective study and were randomized to receive ginger (500 mg ginger powder, twice a day for 3 days) or placebo. One hundred and nineteen patients completed the study 57 of them received ginger and 62 received ginger for the frst 3 chemotherapy cycles. Mean age in all patients was 48.6 (25-79) years. After 1st chemotherapy, mean nausea in the ginger and control arms were 1.36 (1.31) and 1.46 (1.28) with no statistically significant difference. After the 2nd chemotherapy session, nausea score was slightly more in the ginger group (1.36 versus 1.32). After 3rd chemotherapy, mean nausea severity in control group was less than ginger group [1.37 (1.14), versus 1.42 (1.30)]. Considering all patients, nausea was slightly more severe in ginger arm. In ginger arm mean nausea score was 1.42 (0.96) and in control arm it was 1.40 (0.92). Mean vomiting scores after chemotherapy in ginger arm were 0.719 (1.03), 0.68 (1.00) and 0.77 (1.18). In control arm, mean vomiting was 0.983 (1.23), 1.03 (1.22) and 1.15 (1.27). In all sessions, ginger decreased vomiting severity from 1.4 (1.04) to 0.71 (0.86). None of the differences were significant. In those patients who received the AC regimen, vomiting was less severe (0.640.87) comparing to those who received placebo (1.131.12), which was statistically significant (p-Value <0.05). Further and larger studies are needed to draw conclusions.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
MiR-675 Promotes the Growth of Hepatocellular Carcinoma Cells Through Cdc25A Pathway
3881
3885
33071
EN
Ya-Qun
Yu
Department of Hepatobiliary Surgery, the Affiliated Hospital of Guilin Medical College, Guilin, China
Jun
Weng
Shu-Qun
Li
Bo
Li
Jun
Lv
Journal Article
1970
01
01
<span style="text-decoration: underline;"><span style="font-size: small;">Background</span></span><span style="font-size: small;">: MicroRNAs (miRNAs) have fundamental roles in tumorigenesis. MiR-675 is upregulated in hepatocellular carcinoma(HCC) cells. However, the roles of miR-675 in hepatocellular carcinogenesis are still not fully elucidated. In this study, we focus on investigating the effect and mechanism of miR-675 in proliferation of HCC cells. <span style="text-decoration: underline;">Materials and Methods</span>: The cell proliferation was measured by MTT assays after transfection with miR-675 inhibitor and miR-675 mimics in HCC cells. The expression level of miR-675 was detected by real-time quantitative reverse transcription polymerase chain reaction. Protein expression of Cdc25A was measured by western blotting analysis. <span style="text-decoration: underline;">Results</span>: In MTT assays, overexpression of miR-675 promoted the proliferation of HCC cells(</span><em><span style="font-family: Times,Times; font-size: small;"><span style="font-family: Times,Times; font-size: small;">P</span></span></em><span style="font-size: small;"><em><span style="font-family: Times,Times; font-size: small;"><span style="font-family: Times,Times; font-size: small;">P</span></span></em><span style="font-size: small;"><em><span style="font-family: Times,Times; font-size: small;"><span style="font-family: Times,Times; font-size: small;">P</span></span></em><span style="font-size: small;"><em><span style="font-family: Times,Times; font-size: small;"><span style="font-family: Times,Times; font-size: small;">P</span></span></em><span style="font-size: small;"><em><span style="font-family: Times,Times; font-size: small;"><span style="font-family: Times,Times; font-size: small;">p</span></span></em><span style="font-size: small;"><0.05) after treatment with miR-675 mimics. The expression level of Cdc25A was significantly decreased (</span><em><span style="font-family: Times,Times; font-size: small;"><span style="font-family: Times,Times; font-size: small;">p</span></span></em><span style="font-size: small;"><0.05) after treatment with miR-675 inhibitor. <span style="text-decoration: underline;">Conclusions</span>: Our results indicate that miR-675 promotes the proliferation in human hepatocellular carcinoma cells by associating with Cdc25A signaling pathway. </span></span></span></span></span>
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Barriers to Breast and Cervical Cancer Screening in Singapore a Mixed Methods Analysis
3887
3895
33072
EN
Chetna
Malhotra
Lien Centre for Palliative Care, Duke-NUS Medical School, Singapore
Marcel
Bilger
Joy
Liu
Eric
Finkelstein
Journal Article
1970
01
01
Background In order to increase breast and cervical cancer screening uptake in Singapore, women's perceived barriers to screening need to be identi ed and overcome. Using data from both focus groups and surveys, we aimed to assess perceived barriers and motivations for breast and cervical cancer screening. Materials and Methods We conducted 8 focus groups with 64 women, using thematic analysis to identify overarching themes related to women's attitudes towards screening. Based on recurring themes from focus groups, several hypotheses regarding potential barriers and motivations to screen were generated and tested through a national survey of 801 women aged 25-64. Results Focus group participants had misconceptions related to screening, believing that the procedures were painful. Cost was an issue, as well as ef cacy and fatalism. Conclusions By identifying barriers to and motivators for screening through a mixed-method design that has both nuance and external validity, this study offers valuable suggestions to policymakers to improve breast and cervical cancer screening uptake in Singapore.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Change in Trend in Various Clinico-Pathological Factors and Treatment Pro le of Breast Cancer Patients a Tertiary Cancer Centre Experience
3897
3901
33073
EN
Abhishek
Shankar
Department of Radiation Oncology, Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
0000-0001-6491-0079
Shubham
Roy
GK
Rath
Vineet Kumar
Kamal
Menal
Bhandari
Rashi
Kulshrestha
Neelam
Prasad
Jaineet
Sachdev
Pamela
Jeyaraj
Journal Article
1970
01
01
Background Breast cancer is by far the most frequent cancer of women (23% of all cancers), ranking second overall when both sexes are considered together. Since there has been change in clinico-pathological factors and treatment profiles for breast cancer patients over the years, the present study to evaluate the change trends in India. Materials and Methods A detailed analysis was carried out with respect to age, menopausal status, family history, disease stage, surgery performed, histopathology, hormone receptor status, and use of chemotherapy or hormonal therapy. Change in various clinico-pathological factors and treatments of breast cancer cases was recorded and analysed. Results Mean age at presentation was found to be earlier in 2005-2006 compared with 1997-98 (p value 0.046). More premenopausal women were diagnosed with breast cancer in 2005-2006 when this was compared with initial years of assessment (p value 0.001). When change in the receptor status was evaluated, we observed that there was a decrease in cases of ER and PR receptor positivity which was significant (p value 0.007). Over the period of time, more f patients were not offered surgery initially in view of advanced disease when the two time periods were compared (p value 0.001). There was a significant increase in patients who were initially offered neo-adjuvant chemotherapy in view of advanced disease at presentation (p value 0.001). There was increasing number of patients who received palliative treatment for symptoms in 2005-2006 when compared to patients treated in 1997-98((p value 0.001). Conclusions Changes in mean age at presentation, premenopausal status, and stage at presentation have occurred over the years. More aggressive patterns of disease have become more common with early age at presentation and aggressive biological behaviour with receptor negative tumours.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Expression of Human Epidermal Growth Factor Receptor (Her 2/neu) and Proliferative Marker Ki-67 Association with Clinicopathological Parameters in Gallbladder Carcinoma
3903
3909
33074
EN
Mukta
Pujani
Pathology, ESIC Medical College, Faridabad, Haryana Previously, Hamdard Institute of Medical Sciences and Research (HIMSR), New Delhi, India
Isha
Makker
Annu
Makker
Sujata
Jetley
Madhu Mati
Goel
Journal Article
1970
01
01
Purpose To evaluate the expression of Her2/neu and Ki-67 in benign and malignant gallbladder lesions, and to establish correlations with clinico-pathologic parameters. Materials and Methods A retrospective analysis was conducted on formalin xed paraf n embedded (FFPE) benign (n25) and malignant gallbladder (n25) tissue samples. Hematoxylin and eosin stained slides of each case were reviewed for type of malignancy (whether adenocarcinoma, squamous cell carcinoma, or any other type), grade (well, moderate, and poor), depth of invasion, pre-neoplastic changes in adjacent mucosal epithelium like metaplasia and dysplasia. Immunohistochemistry for Her 2 neu and Ki-67 was performed and data analysis was conducted using SPSS 17 software. Chi-square test was used to compare categorical/dichotomous variables. P value of 0.05 was considered signi cant. Results The difference of Her 2 neu expression and Ki67 index between benign and malignant groups was found to be statistically signi cant. Her2/neu positivity did not have any signi cant correlation with various clinicopathological parameters other than liver involvement. 5 cases of gallbladder cancer showed both Her2/neu and Ki67 positivity. Ten cases were Ki67 positive but Her2/neu negative while one case was Her2/neu positive but Ki67 negative. Conclusions The present study demonstrated overexpression of Her2/neu and Ki67 in gallbladder cancer. A trend of decreasing Her2/neu expression with increasing grade of tumor was observed. Furthermore, greater Ki67 positivity was found in cases with lymph node metastasis and distant metastasis. Future studies with a larger number of patients will be required to precisely de ne the correlation of Her2/neu expression and Ki67 positivity with clinicopathological parameters. The results however are encouraging and suggest evaluation of Her2/neu as a candidate for targeted therapy.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Survival of Triple Negative versus Triple Positive Breast Cancers Comparison and Contrast
3911
3916
33075
EN
Preety
Negi
Radiation Oncology, Christian Medical College & Hospital, Ludhiana , Ludhiana, India
0000-0001-5397-9206
Pamela Alice
Kingsley
Kunal
Jain
Jaineet
Sachdeva
Himanshu
Srivastava
Sudeep
Marcus
Aman
Pannu
Journal Article
1970
01
01
Background Triple negative (TN) and triple positive (TP) breast cancers both are aggressive types but TN generally has a shorter survival. Objectives To compare the clinical characteristics and treatment outcomes for patients with TN versus TP breast cancer and to assess various prognostic factors affecting overall survival. Materials and Methods A retrospective audit of 85 breast cancer patients was conducted in the Department of Radiation Oncology and Medical Oncology on patients from 2006 to 2013 for whom IHC for ER, PgR and Her-2 neu were available. The patients were strati ed into ER-, PR- and Her-2 neu- (Arm A, n47) and ER+, PgR+ and Her-2 neu+ (Arm B, n38). Results TN subtype had higher numbers of premenopausal and advanced stage patients as compared to TP subtype. The locoregional recurrence (LRR) and distant metastatic rate was also higher in TN subtype but there was no de nite pattern in both the arms. Among the prognostic factors, patients with premenopausal status and advanced stage in TN breast cancer had inferior survival (P0.07) whereas for those with postmenopausal status and early stage there was no survival difference between the two arms. Conclusions TN subtype tends to be more aggressive in terms of younger age and advanced stage at presentation, higher tumour grade, LRR and metastasis, suggesting need for future research efforts on providing aggressive treatment to these patients. We could attribute better outcome for TP subtype to receptor positivity enabling role of hormonal treatment and targeted therapy, although less number of patients received targeted therapy.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
No association Between Calcium Channel Blockers and Survival in Patients with Cancer A systematic Review and Meta-analysis
3917
3921
33076
EN
Hong
Sun
Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, China
Rong-Yuan
Zhuang
Tao
Li
Yuan-Ting
Zheng
Wei-Min
Cai
Journal Article
1970
01
01
Background The association between calcium channel blockers (CCBs) and survival in cancer patients remains unclear and the results of related studies are con icting. The objective of the study was to investigate the association between calcium channel blockers (CCBs) use and survival in cancer patients. Materials and Methods We searched PubMed, EMBASE, Web of Science and Cochrane Library for studies published before January 2016 with the terms related to CCBs and survival in cancer patients. The information was reviewed and extracted by two evaluators independently. Data of publications was extracted and calculated into hazard ratios (HRs) for overall survival (OS). Statistical analysis was performed by using Review Manager 5.3. Results There were 11 studies included in our meta-analysis. Analysis of all studies showed that CCBs use was not associated with survival in cancer patients (HR1.07; 95% CI 0.91-1.25; P0.42). No association between CCBs use and overall survival in cancer patients was existed whether in Asian (HR1.18, 95% CI 0.72-1.93; P0.52) or Caucasian population (HR1.03, 95% CI 0.89-1.20; P0.66). Conclusions There is no evidence that CCBs use is associated with a better or worse outcome of survival in cancer patients.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Lack of TNF-α Gene Polymorphism (rs1799724) Association with Sustained Virological Response in Iranian Patients with Chronic HCV Infection
3923
3927
33077
EN
Mona Sadat
Larijani
Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
Narges
Bahiraei
Mehri
Nikbin
Nasir
Mohajel
Leila Naghizadeh
Rad
Fahimeh
Baghbani
Maryam
Mapar
Seyed Mehdi
Sadat
Journal Article
1970
01
01
Infection with the hepatitis C virus is a major public health concern which can lead to carcinoma and liver failure. It has been shown that single nucleotide polymorphisms can affect the level of gene activity of tumor necrosis factor (TNF) which has an important role, especially in viral infections which can lead to apaptosis of infected hepatocellular cells. We investigated the impact of three possible genotypes for rs1800629 or A/G single nucleotide polymorphism located downstream of TNF gene promoter in groups of control (n76) and chronic hepatitis C patients (n89) focusing on the response to treatment among sensitive and resistant groups. Genomic DNA was extracted from 500 l prepheral whole blood and PCR and RFLP were used to amplify the region of interest and genotyping. With statistical analyzes a p-value
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan HSP70 is Predictive of Poor Prognosis
3929
3937
33078
EN
Khaldon
Bodoor
Department of Applied Biology. Jordan University of Science and Technology, Irbid, Jordan
Sara Abu
Jalboush
Ismail
Matalka
Aya
Abu-Sheikha
Rofieda Al
Waq
Hanadi
Ebwaini
Aymen
Abu-Awad
Luma
Fayyad
Jamal
Al-Arjat
Yazan
Haddad
Journal Article
1970
01
01
Gastric cancer (GC) is a major health problem worldwide and is one of the ten most commonly diagnosed cancers in Jordan. GC is usually diagnosed at late aggressive stages in which treatment options are limited. Recently, heat shock proteins (HSPs) were found to be overexpressed in a wide range of malignancies have been considered as promising candidate biomarkers for GC. The aim of this study was to investigate pathogenic roles of a panel of cytosolic HSPs including HSP90, HSP70, HSP60 and HSP27 in GC. Immunohistochemistry was used to assess the level of expression of these proteins in archived tumor samples (N87) representing various pathological characteristics of GC. HSP90, HSP60 and HSP27 were expressed abundantly in gastric tumors. On the other hand, HSP70 was reduced signi cantly and also found to be associated with Helicobacter pylori infection in tissues collected from GC patients. Furthermore, HSP27 was found to be associated with the level of differentiation. Our ndings indicate a role of HSP70 as a potential prognostic biomarker, patients harboring positive HSP70 expression displaying worse disease free survival than those with negative HSP70 expression. Differential expression of HSPs may play crucial roles in the initiation and progression of GC, and could be exploited as future therapeutic targets.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Factors Affecting Preferences of Iranian Women for Breast Cancer Screening Based on Marketing Mix Components
3939
3943
33079
EN
Farhad
Pourfarzi
Community medicine group, faculty of medicine, Ardabil University of medical sciences, Ardebil, Iran
Nasrin
Fouladi
Firouz
Amani
Saeid Sadegieh
Ahari
Zohre
Roshani
Sara
Alimohammadi
Journal Article
1970
01
01
Background According to recent statistics, the breast cancer rate is growing fast in developing countries. In North West of Iran, the incidence of breast cancer after esophageal and gastric cancers has the highest rate. Previous studies have also indicated that women in this region show reluctance to do breast cancer screening. There is a great need for change to promote breast cancer screening among women. Social marketing is a discipline that uses the systematic application of commercial marketing techniques to promote the adoption of behavior by the target audience. Materials and Methods In the present qualitative study, thirty-two women with breast cancer were interviewed about their experiences of breast cancer screening. A semi-structured interview guide was designed to elicit information speci c to the 4 P's in social marketing. Results Three main categories emerged from the analysis price, service and promotion. Subcategories related to these main categories included factors effective in increasing and decreasing cost of screening, current and desirable features of screening services, and weakness of promotion. Conclusions Screening programs should be designed to be of low cost, to meet patients' needs and should be provided in suitable places. Furthermore, it is essential that the cultural beliefs of society be improved through education. It seems necessary to design an executive protocol for breast cancer screening at different levels of primary health care to increase the women's willingness to undergo screening.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Significant Efficacy of Additional Concurrent Chemotherapy with Radiotherapy for Postoperative Cervical Cancer with Risk Factors a Systematic Review and Meta-analysis
3945
3951
33080
EN
Ai-Qiu
Qin
Department of Gynecology Oncology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China
Zhong-Guo
Liang
Jia-Xiang
Ye
Jing
Li
Jian-Li
Wang
Chang-Xian
Chen
Hong-Lin
Song
Journal Article
1970
01
01
Background Whether concurrent chemotherapy treatment is superior to radiotherapy alone as an adjuvant regimen for postoperative cervical carcinoma with risk factors remains controversial. Materials and Methods A literature search strategy examined Pubmed, Embase, the Cochrane Library, the China National Knowledge Internet Web, the Chinese Biomedical Database and the Wanfang Database. Article reference lists and scienti c meeting abstracts were also screened. Controlled trials comparing concurrent chemoradiotherapy versus radiotherapy alone in postoperative cervical cancer were included. The methodological quality of non- randomized controlled trials was evaluated using the Newcastle-Ottawa Scale. Randomized controlled studies were evaluated with the Cochrane handbook. A meta-analysis was performed with RevMan 5.3. Results A total of 1,073 patients from 11 clinical trials were analysed, with 582 patients in the concurrent chemoradiotherapy group and 491 patients in the radiotherapy group. Hazard ratios (HR) of 0.47 (95% CI 0.31-0.72) and 0.50 (95% CI 0.35-0.72) were observed for overall survival and progression-free survival, indicating a bene t from the additional use of concurrent chemotherapy. Subgroup analyses demonstrated that cervical cancer with high risk factors signi cantly bene tted from concurrent chemotherapy when examining overall survival (HR 0.44, 95% CI 0.28-0.67) and progression-free survival (HR 0.48, 95% CI 0.33-0.70), but patients with intermediate risk factors showed no bene t from concurrent chemotherapy in overall survival (HR 1.72, 95% CI 0.28-10.41) and progression-free survival (HR 1.09, 95% CI 0.19-6.14). No signi cant differences were observed for grade 3-4 anaemia (risk ratio (RR) 3.87, 95% CI 0.69-21.84), grade 3-4 thrombocytopenia (RR 3.04, 95% CI 0.88- 10.58), grade 3-4 vomiting or nausea (RR 1.71, 95% CI 0.27-10.96), or grade 3-4 diarrhoea (RR 1.40, 95% CI 0.69-2.83). Signi cant differences were observed for grade 3-4 neutropenia in favour of the radiotherapy group (RR 7.23, 95% CI 3.94-13.26). Conclusions In conclusion, concurrent chemoradiotherapy improves survival in postoperative cervical cancer with high risk factors but not in those with intermediate risk factors.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Frequency and Type Distribution of Human Papilloma Virus in Patients with Prostate Cancer, Kerman, Southeast of Iran
3953
3958
33081
EN
Fatemeh
Atashafrooz
Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
Farokh
Rokhbakhsh-Zamin
Journal Article
1970
01
01
Prostatic cancer is the second cause of cancer-related death among men worldwide. The human papilloma viruses (HPVs) are a family of sexually transmitted viruses which have may have roles in the ethiology of in ammation in prostate leading to benign prostatic hyperplasia (BPH) and prostate cancer (PCa). In this study, we evaluated the frequency of different HPV types in prostatic cancer and benign prostatic hyperplasia (BPH) in Kerman province, southeast of Iran, using real-time PCR techniques. The aim of the present research was to clarify any association with prostatic carcinogenesis. Real Time PCR showed that HPV DNA was found in 20% of 200 PCa samples, 80 percent of these with high-risk HPV types, 40% with type-16,18, 30 % type-31,33 and 10% type 54. High risk HPV DNA was detected in only 2% of BPH samples. Values for low risk types were much higher. Our study provided a support for the role of high risk HPV infection in prostatic disease in Iranian patients, and association between presence of HPV DNA and prostate carcinoma. In particular, HPV 16 and18 might have an important role in prostate cancer.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
TET2 Promoter DNA Methylation and Expression in Childhood Acute Lymphoblastic Leukemia
3959
3962
33082
EN
Gholamreza
Bahari
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Mohammad
Hashemi
Majid
Naderi
Mohsen
Taheri
Journal Article
1970
01
01
The ten-eleven-translocation-2 (TET2) gene is a novel tumor suppressor gene involved in several hematological malignancies of myeloid and lymphoid origin. Besides loss-of-function mutations and deletions, hypermethylation of the CpG island at the TET2 promoter has been found in human cancers. The TET2 encoded protein regulates DNA methylation. The present study aimed to examine DNA promoter methylation of TET2 in 100 childhood acute lymphoblastic leukemia (ALL) cases and 120 healthy children in southeast Iran. In addition, mRNA expression levels were assessed in 30 new cases of ALL and 32 controls. Our ndings indicated that promoter methylation of TET2 signi cantly increases the risk of ALL (OR2.60, 95% CI1.31-5.12, p0.0060) in comparison with absent methylation. Furthermore, the TET2 gene was signi cantly downregulated in childhood ALL compared to healthy children (p0.0235). The results revealed that hypermethylation and downregulation of TET2 gene may play a role in predisposition to childhood ALL. Further studies with larger sample sizes and different ethnicities are needed to con rm our ndings.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Association of IGFBP-6 Expression with Metabolic Syndrome and Adiponectin and IGF-IR Receptor Levels in Colorectal Cancer
3963
3969
33083
EN
Natalia V
Yunusova
Tomsk Cancer Research Institute, Tomsk, Russian Federation, Tomsk, Russian
Liudmila V
Spirina
Alena E
Frolova
Sergey G
Afanas'ev
Elena S
Kolegova
Irina V
Kondakova
Journal Article
1970
01
01
Purpose To assess IGFBP-6 expression in relation with the presence of the metabolic syndrome, adiponectin receptors (AdipoR1 and AdipoR2) and IGF-IR levels in colorectal adenocarcinoma cases. Materials and Methods IGFBP-6 mRNA and protein levels were analyzed using real-time quantitative PCR and Western blotting in 46 patients. ELISA and ow cytometry were used for evaluation of AdipoR1, AdipoR2 and IGF-IR. Results The results showed that IGFBP-6 mRNA expression and the IGFBP-6 content were higher in tumor tissue samples of colorectal cancer patients with tahtn without metabolic syndrome. In addition, the IGFBP-6 mRNA expression was associated with tumor invasion (tumor size) and the IGFBP-6 protein level was associated with nodal status. Positive correlations and positive nonlinear relations were found between the IGFBP-6 level and the AdipoR1 and AdipoR2 contents in colorectal cancer patients. Conclusions The IGFBP-6 mRNA level and protein level were found to be associated with presence of metabolic syndrome. Positive correlations indicated probable cross-talk between the IGF-IR-mediated and adiponectin-mediated signaling pathways in colorectal carcinomas. IGFBP-6 may be considered as a potential biomarker associated with lymphogenous metastasis and the metabolic syndrome in colorectal cancer.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Screening for the 3' UTR Polymorphism of the PXR Gene in South Indian Breast Cancer Patients and its Potential role in Pharmacogenomics
3971
3977
33084
EN
Sundaramoorthy
Revathidevi
Department of Genetics, Dr ALM PG Institute Basic Medical Sciences University of Madras, Taramani, Chennai Tamil Nadu, India
Ravi
Sudesh
Varadharajan
Vaishnavi
Muthukrishnan
Kaliyanasundaram
Kilyara George
MaryHelen
Ganesan
Sukanya
Arasambattu Kannan
Munirajan
Journal Article
1970
01
01
Background Breast cancer, the commonest cancer among women in the world, ranks top in India with an incidence rate of 1,45,000 new cases and mortality rate of 70,000 women every year. Chemotherapy outcome for breast cancer is hampered due to poor response and irreversible dose-dependent cardiotoxicity which is determined by genetic variations in drug metabolizing enzymes and transporters. Pregnane X receptor (PXR), a member of the nuclear receptor superfamily, induces expression of drug metabolizing enzymes (DMEs) and transporters leading to regulation of xenobiotic metabolism. Materials and Methods A genomic region spanning PXR 3' UTR was amplified and sequenced using genomic DNA isolated from 96 South Indian breast cancer patients. Genetic variants observed in our study subjects were queried in miRSNP to establish SNPs that alter miRNA binding sites in PXR 3' UTR. In addition, enrichment analysis was carried out to understand the network of miRNAs and PXR in drug metabolism using DIANA miRpath and miRwalk pathway prediction tools. Results In this study, we identified SNPs rs3732359, rs3732360, rs1054190, rs1054191 and rs6438550 in the PXR 3; UTR region. The SNPs rs3732360, rs1054190 and rs1054191 were located in the binding site of miR-500a-3p, miR-532-3p and miR-374a-3p resulting in the altered PXR level due to the deregulation of post-transcriptional control and this leads to poor treatment response and toxicity. Conclusions Genetic variants identified in PXR 3' UTR and their effects on PXR levels through post-transcriptional regulation provide a genetic basis for inter- individual variability in treatment response and toxicity associated with chemotherapy.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Association between Pesticide Use and Cholangiocarcinoma
3979
3982
33085
EN
Kornthip
Jeephet
Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen Universtity, Khon Kaen, Thailand
Siriporn
Kamsa-ard
Vajarabhongsa
Bhudhisawasdi
Supot
Kamsa-ard
Varisara
Luvira
Vor
Luvira
Journal Article
1970
01
01
Background Thailand remains a primarily agricultural country and Thai farmers are heavy users of pesticides. Coincidentally the incidence of cholangio carcinoma (CCA) is high in parts of the country, but no previous study has examined any association between the two. Materials and Methods The present matched, case-control study covered patients admitted to Srinagarind Hospital, Khon Kaen University, Thailand. The case group comprised 210 cases diagnosed with CCA and the control group 840 diagnosed with other diseases. Cases and controls were matched for sex, age within five years, and date of admission within three months. Multiple conditional logistic regression was used for the analysis. Results After adjusting for potential confounders, pesticide use as compared with never used pesticide was not associated with CCA (ORadj1.11, 95% CI 0.77, 1.60) and neither was there any significant relationship between CCA and duration of pesticide use, type or number of types pesticide use. Conclusions The current study thus found no association between pesticide use and CCA.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Human papillomavirus Infection and its Vaccines Knowledge and Attitudes of Primary Health Clinic Nurses in Kelantan, Malaysia
3983
3988
33086
EN
K
Jeyachelvi
Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia (USM), Kubang kerian, Kelantan, Malaysia
S
Juwita
D
Norwati
Journal Article
1970
01
01
Background Cervical cancer though preventable is still the leading cause of cancer death among women secondary to breast cancer. Persistent infection with HPV has been causally linked to the disease. A school based HPV vaccination program was introduced in late 2010 in Malaysia and nurse support is essential for its success. Objectives To determine nurses knowledge and attitudes about HPV infection and its vaccines, and factors associated with their knowledge. Materials and Methods This cross-sectional study was conducted among nurses working at primary health clinics in Kelantan from mid-June till the end of July 2014. Its involved 330 nurses selected through multistage random sampling. A validated self-administered questionnaire consisting of 11 items for the knowledge domain and eight items for the attitude domain was used. Results The response rate of the study was 93.7%. The mean knowledge and mean attitude (SD) scores were 5.37 (1.76) and 29.8 (3.51) respectively. Only 24% knew that HPV is the most common sexually transmitted infection and 67% correctly answered that Gardasil vaccine can protect against four types of HPV. Nearly 60% of participants wrongly answered that HPV vaccines cannot be offered to sexually active women. Likewise, 70.9% participants were not aware that HPV vaccine may be appropriate for females aged 9 through 26 years. Though 90% of participants believed that the vaccine is safe, nearly half of them were unsure about efficacy. From multiple linear regression analysis, among the factors tested only participant's level of education showed a statistically significant association with the HPV knowledge score (<0.001). Conclusions This study indicates nurses have favorable attitudes towards HPV vaccination; however they have significant knowledge deficit and major misunderstanding in critical knowledge items. Among the factors tested, nursing qualification is the only factor that is significantly associated with the nurses knowledge score.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Association of Genetic Variants in ARID5B, IKZF1 and CEBPE with Risk of Childhood de novo B-Lineage Acute Lymphoblastic Leukemia in India
3989
3995
33087
EN
Prerana
Bhandari
Mentor-Molecular Pathology and Clinical Research Services, Research and Development, Goregaon, Mumbai, India
Firoz
Ahmad
Swarna
Mandava
Journal Article
1970
01
01
Background Childhood acute lymphoblastic leukemia (ALL) is a heterogeneous genetic disease and its etiology remains poorly understood. Recent genome wide association and replication studies have highlighted speci c polymorphisms contributing to childhood ALL predispositions mostly in European populations. It is unclear if these observations generalize to other populations with a lower incidence of ALL. The current case-control study evaluated variants in ARID5B (rs7089424, rs10821936), IKZF1 (rs4132601) and CEBPE (rs2239633) genes, which appear most signi cantly associated with risk of developing childhood B-lineage ALL. Materials and Methods Using TaqMan assays, genotyping was conducted for 162 de novo B-lineage ALL cases and 150 unrelated healthy controls in India. Appropriate statistical methods were applied. Results Genotypic and allelic frequencies differed signi cantly between cases and controls at IKZF1-rs4132601 (p0.039, p0.015) and ARID5B-rs10821936 (p0.028, p0.026). Both rs10821936 (p0.019; OR 0.67; 95% CI0.47-0.94) and rs4132601 (p0.018; OR 0.67; 95%CI 0.48-0.94) were associated with reduced disease risk. Moreover, gender- analysis revealed male-speci c risk associations for rs10821936 (p0.041 CT+CC) and rs4132601 (p0.005 G allele). Further, ARID5B-rs7089424 and CEBPE-rs2239633 showed a trend towards decreased disease risk but without signi cance (p0.073; p0.73). Conclusions Our ndings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children. Understanding the effects of these variants in different ethnic groups is crucial as they may confer different risk of ALL within different populations.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Assessment of the Nature and Severity of Pain Using SF-MPQ for Cancer Patients at the National Institute of Oncology in Rabat in 2015
3997
4001
33088
EN
Rouahi
Nabila
Institut Superieur des Professions Infirmieres et Techniques de Sante (ISPITS, Ex-IFCS), Route Casablanca, Rabat, Morocco
0000-0001-8128-2350
OuazzaniTouhami
Zineb
Ahyayauch
Hasna
El Mlili
Nisrin
Filali-Maltouf
A
Belkhadir
Zakaria
Journal Article
1970
01
01
Background Cancer is a worldwide health problem and pain is among the most common and unpleasant effects affecting well-being of cancer patients. Accurate description of pain can help physicians to improve its management. Many English tools have been developed to assess pain. Onkly a limited number of these are applied in Arab countries. Our aim was to assess the quality, the nature and the severity of pain using the short McGill Pain Questionnaire (SF-MPQ) on cancer patients in the National Institute of Oncology (NIO) in Rabat, Morocco. Materials and Methods The tool used is the SF-MPQ inspired from the Arabic version of the MPQ. The subjects were cancer patients (N182) attending the NIO, from 24th October 2015 to 8th January 2016, aging 18 years old, experiencing pain and coming to have or to update their pain medication. Results The rate of participation was 96.3%. Eight patients haddif culties to express their pain using descriptors, but could use the Visual Analogue Scale (VAS) and the body diagram. The most frequent sensory descriptors were 'Throbbing', 'Shooting', 'Hot-Burning'. The most used affective descriptor was 'Tiring-Exhausting'. The mean VAS was 6.6 (2.4). The mean score of all items was 11.9 (7.8). The patients were suffering from severe pain. The internal consistency of the form was s acceptable. Conclusions The ndings indicate that most of the patients attending the pain center of the NIO could use the descriptors of the SF-MPQ to describe their pain. The ndings indicate the usefulness of the SF-MPQ to assess the nature and the severity of pain in cancer patients. This tool should be tested in other Moroccan and Arabic contexts associated with other tools in clinical trials.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Sex Steroids Regulate Expression of Genes Containing Long Interspersed Elements-1s in Breast Cancer Cells
4003
4007
33089
EN
Saichon
Chaiwongwatanakul
Department of Biological Sciences, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
Pattamawadee
Yanatatsaneejit
Sissades
Tongsima
Apiwat
Mutirangura
Viroj
Boonyaratanakornkit
Journal Article
1970
01
01
Long interspersed elements-1s (LINE-1s) are dispersed all over the human genome. There is evidence that hypomethylation of LINE-1s and levels of sex steroids regulate gene expression leading to cancer development. Here, we compared mRNA levels of genes containing an intragenic LINE-1 in breast cancer cells treated with various sex steroids from Gene Expression Omnibus (GEO), with the gene expression database using chi-square analysis (http//www.ncbi.nlm.nih.gov/geo). We evaluated whether sex steroids in uence expression of genes containing an intragenic LINE-1. Three sex steroids at various concentrations, 1 and 10 nM estradiol (E2), 10 nM progesterone (PG) and 10 nM androgen (AN), were assessed. In breast cancer cells treated with 1 or 10 nM E2, a signi cant percentage of genes containing an intragenic LINE-1 were down-regulated. A highly signi cant percentage of E2-regulated genes containing an intragenic LINE-1 was down-regulated in cells treated with 1 nM E2 for 3 hours (<3.70E-25; OR1.91; 95% CI2.16-1.69). Similarly, high percentages of PG or AN- regulated genes containing an intragenic LINE-1 wwere also down-regulated in cells treated with 10 nM PG or 10 nM AN for 16 hr (p9.53E-06; OR1.65; 95% CI2.06-1.32 and p3.81E-14; OR2.01; 95% CI2.42-1.67). Interestingly, a signi cant percentage of AN-regulated genes containing an intragenic LINE-1 was up-regulated in cells treated with 10 nM AN for 16 hr (p4.03E-02; OR1.40; 95% CI1.95-1.01). These ndings suggest that intragenic LINE-1s may play roles in sex steroid mediated gene expression in breast cancer cells, which could have signi cant implications for the development and progression of sex steroid-dependent cancers.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Clinico-Hematological Findings for Classical Hodgkin's Lymphoma an Institutional Experience
4009
4011
33090
EN
Sadia
Sultan
Department of Hematology & Blood bank, Liaquat National Hospital and Medical College, Karachi, Pakistan
Syed Mohammed
Irfan
Saira
Parveen
Saif
Ali
Journal Article
1970
01
01
Background Classical Hodgkin's lymphoma (cHL) is a B-cell lymphoid neoplasm characterized by a distinctive biological behavior with potentially curable disease characteristics. It is an uncommon hematological malignancy which primarily affects younger individuals. The rationale of this study was to determine its clinico-hematological pro le along with stage strati cation in Pakistani patients. Materials and Methods In this descriptive study, adult patients with Hodgkin's lymphoma were enrolled from January 2010 to December 2014. Results Sixty two histopathologically con rmed cases of cHL were identi ed. There were 42 males and 20 females, with a male to female ratio of 2 1. The mean age was 29.713.8 years with the median age of 30 years. B symptoms were present in 72.5% of patients. Histopathologically, the mixed cellularity type constituted 62.9% of cases, followed by nodular sclerosis in 25.8%, lymphocyte predominant in 9.6% and lymphocyte depleted in 1.6%. Stages I and II were present in 43.5% of patients at disease presentation, with 56.4% in stages III and IV. Conclusions Our analysis shows that clinico-pathological features of Hodgkin's lymphoma in Pakistan are comparable to published data. Mixed cellularity is the commonest histological variant and advanced stage at presentation are common ndings in our patients.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Does Microinvasive Adenocarcinoma of Cervix Have Poorer Treatment Outcomes than Microinvasive Squamous Cell Carcinoma
4013
4017
33091
EN
Irene
Ruengkhachorn
Gynecologic Oncology Division, Department of Obstetrics & Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
0000-0001-9888-7479
Suchanan
Hanamornroongruang
Chairat
Leelaphatanadit
Suthi
Sangkarat
Journal Article
1970
01
01
Background To compare the pathological ndings and oncologic outcomes of stage IA cervical carcinoma patients, between adenocarcinoma and squamous cell carcinoma cases. Materials and Methods A total of 151 medical records of stage IA cervical carcinoma patients undergoing primary surgical treatment during 2006-2013 were reviewed. Information from pathological diagnosis and recurrence rates were compared with descriptive statistical analysis. The Kaplan-Meier method and Cox proportional hazards model were used for survival analysis. Results The median age was 48.9 years. There was no signi cant difference in rates of lymph node, parametrium, uterine, vaginal, or ovarian metastasis, when comparing adenocarcinoma with squamous cell carcinoma. Overall recurrence rate of adenocarcinoma (5.7%) and squamous cell carcinoma (2.6%) was not statistically signi cant difference, even when strati ed by stage. When comparing progression free survival with squamous cell carcinoma, adenocarcinoma had an HR of 0.448 (0.073-2.746), p0.386. Conclusions Microinvasive adenocarcinoma of cervix has similar rate of extracervical involvement and oncologic outcomes to squamous cell carcinoma.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Plant Phenolics Ferulic Acid and P-Coumaric Acid Inhibit Colorectal Cancer Cell Proliferation through EGFR Down- Regulation
4019
4023
33092
EN
Nabarun
Roy
Distributed Information Centre, Kerala Agricultural University, Thrissur, Kerala, India
Arunaksharan
Narayanankutty
PA
Nazeem
Ravisankar
Valsalan
TD
Babu
Deepu
Mathew
Journal Article
1970
01
01
Background Colorectal cancer (CRC) or bowel cancer is one of the most important cancer diseases, needing serious attention. The cell surface receptor gene human epidermal growth factor receptor (EGFR) may have an important role in provoking CRC. In this pharmaceutical era, it is always attempted to nd out plant based drugs for cancer, which will have less side effects for human body, unlike the chemically synthesized marketed drugs having serious side effects. So, in this study the authors tried to assess the activity of two important plant compounds, ferulic acid (FA) and p-coumaric acid (pCA), on CRC. Materials and Methods FA and pCA were tested for their cytotoxic effects on human CRC cell line HCT 15 and also checked for the level of gene expression of EGFR by real time PCR analysis. Positive results were con rmed by in silico molecular docking studies using Discovery Studio (DS) 4.0. The drug parallel features of the same compounds were also assessed in silico. Results Cytotoxicity experiments revealed that both the compounds were ef cient in killing CRC cells on a controlled concentration basis. In addition, EGFR expression was down-regulated in the presence of the compounds. Docking studies unveiled that both the compounds were able to inhibit EGFR at its active site. Pharmacokinetic analysis of these compounds opened up their drug like behaviour. Conclusions The ndings of this study emphasize the importance of plant compounds on targeting diseases like CRC.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Inverse Correlation between Cancer Size and Abdominal Obesity in Colorectal Cancer Cases
4025
4030
33093
EN
Taek Gun
Jeong
Departments of Internal Medicine, Radiology, Pathology, and Surgery, Konkuk University School of Medicine, Seoul, Korea
Ji Wan
Kim
Sun-Young
Lee
Hee Sun
Park
Hye Seung
Han
Dae Yong
Hwang
Journal Article
1970
01
01
Background Correlation between colorectal cancer (CRC) and abdominal obesity has been established, but there is a paucity of data on non-obese CRC patients. The aim of this study was to establish the characteristics of CRCs that occur in such patients. Materials and Methods Consecutive CRC patients without cachexia were included. Unintended body weight loss, T4- or M1-staged CRCs, extensive lymph node involvement, or synchronous malignancy were classi ed as cachectic conditions. Abdominal fat volumes were measured using a multidetector CT unit with a software (Rapidia, INFINITT, Seoul, Korea). Results Of the newly-diagnosed CRC patients, 258 non-cachectic and 88 cachectic patients were analyzed. The cancer size (p<0.001) and T stage (p<0.001) were inversely correlated with body mass index (BMI), visceral fat and subcutaneous fat volumes. Cancer size was the only independent factor related to BMI (p0.016), visceral fat volume (p0.002), and subcutaneous fat volume (p0.027). In non-cachectic patients, a signi cant inverse correlation was found only between the cancer size and visceral fat volume (p0.017). Conclusions Non-obese CRC patients tend to have larger CRC lesions than their obese counterparts even under non-cachectic conditions. Such an inverse correlation between cancer size and visceral fat volume suggests that considerable CRCs are not correlated with abdominal obesity.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Phase II Study of Compliance and Morbidity with 4 Cycles of Taxotere Followed by 4 of Doxorubicin-Cyclophosphamide for Adjuvant Treatment of Operable Breast Cancer Patients
4031
4035
33094
EN
Rami Jalal
Yaghan
Faculty of Medicine, Jordan University of Science and Technology and af liated King Abdulla Teaching Hospital, Irbid, Jordan
Nawaf Mahmood
Dagher
Journal Article
1970
01
01
Background In the adjuvant treatment of breast cancer, anthracycline and taxane based regimens can be used concomitantly or sequentially. The best order in the sequential regimens has yet to be well established. This study evaluated the feasibility of 4 cycles of adjuvant taxotere (100mg/m2) every 3 weeks followed by 4 cycles of doxorubicin (60 mg/m2) and cyclophosphamide (600mg/m2) every 3 weeks. The primary outcome was the safety pro le. Secondary outcomes were disease free survival (DFS) and overall survival (OS). Materials and Methods This non-randomize prospective phase II stud was performed at Jordan University of Science and Technology and its af liated King Abdulla Teaching Hospital between July 2009 and August 2010. Data collection was closed on May 31th, 2015 giving a median follow up period of 62 months. The study was approved by the institutional review board and a written informed consent was obtained for each patient. Results Fifty patients were enrolled. The median age was 53.1 years (range 34-76). One patient (2%) had stage I disease, 17 (34%) stage II, and 32 (64.0%) stage III. Forty-six patients were evaluable for ef cacy analysis. The completion rate was 95.7%. No dose modi cations were needed. The incidences of grade 3-4 neutropenia and febrile neutropenia were 14% and 10%. No grade 3-4 non-hematological adverse events were encountered. At a median follow up time of 62 months the OS and the DFS rates were 76.1% and 56.5%. Those for stages I and II combined were 100% and 75%. Conclusions Taxotere rst followed by doxorubicin-cyclophosphamide appears a feasible regimen as evidenced by an acceptable completion rate, a satisfactory safety pro le, and an OS and DFS rates comparable to other studies.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Conventional versus Doxorubicin-Eluting Beads Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma a Tertiary Medical Centre Experience in Malaysia
4037
4041
33095
EN
F Abdul
Rahman
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Raja Muda Aziz, Kuala Lumpur, Malaysia
J
Naidu
CS
Ngiu
Y
Yaakob
Z
Mohamed
H
Othman
R
Jarmin
MH
Elias
N Abdul
Hamid
N Mohd
Mokhtar
RA Raja
Ali
Journal Article
1970
01
01
Background Hepatocellular carcinoma (HCC) is a common cancer that is frequently diagnosed at an advanced stage. Transarterial chemoembolisation (TACE) is an effective palliative treatment for patients who are not eligible for curative treatment. The two main methods for performing TACE are conventional (c-TACE) or with drug eluting beads (DEB-TACE). We sought to compare survival rates and tumour response between patients undergoing c-TACE and DEB-TACE at our centre. Materials and Methods A retrospective cohort study of patients undergoing either treatment was carried out from January 2009 to December 2014. Tumour response to the procedures was evaluated according to the modi ed Response Evaluation Criteria in Solid Tumors (mRECIST). Kaplan-Meier analysis was used to assess and compare the overall survival in the two groups. Results A total of 79 patients were analysed (34 had c-TACE, 45 had DEB-TACE) with a median follow-up of 11.8 months. A total of 20 patients in the c-TACE group (80%) and 12 patients in the DEB-TACE group (44%) died during the follow up period. The median survival durations in the c-TACE and DEB-TACE groups were 4.9 3.2 months and 8.3 2.0 months respectively (p0.008). There was no statistically signi cant difference noted among the two groups with respect to mRECIST criteria. Conclusions DEB-TACE demonstrated a signi cant improvement in overall survival rates for patients with unresectable HCC when compared to c-TACE. It is a safe and promising approach and should potentially be considered as a standard of care in the management of unresectable HCC.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Head and Neck Cancer in Saudi Arabia a Systematic Review A Systematic Review and Updates
4043
4048
33096
EN
Turki Y
Alhazzazi
King Abdulaziz University, Faculty of Dentistry, Department of Oral Biology, Jeddah, Saudi Arabia
Faisal T
Alghamdi
Journal Article
1970
01
01
Background Head and neck cancer (HNC) is the ninth most common cancer worldwide, and has a poor 5-year survival rate averaging 50%, which has not changed for decades. A high prevalence of HNC has been reported in the southwestern region of Saudi Arabia, as compared to other areas of the country. However, data in regards to HNC are scattered and not well documented. Thus, the aim of this systematic review was to gather all available and updated important information regarding HNC in Saudi Arabia, and highlight the gaps of knowledge in our country with regard to this disease. In addition, suggestions of solutions to overcome the current status and improve our future standard of care to fight HNC are also highlighted. Materials and Methods The electronic databases PubMed and Google Scholar using English-language literature were used for this systematic review, using specific inclusion and exclusion criteria and keywords. The search was performed in April 2016 and updated in June 2016. Results Our search revealed twenty-one studies that fulfilled our inclusion and exclusion criteria and that were conducted in Saudi Arabia. These studies investigated different aspects of HNC, including prevalence, risk factors, biomarkers, and assessed knowledge and awareness of both public and practitioners with regard to HNC. Conclusions This review uncovered a big gap in our epidemiological data in cancer information in general, and head and neck cancer in particular. In addition, a lack of knowledge and awareness of both the public and health care practitioners hinders the early diagnosis of disease and negatively impact the prognosis, treatment and outcome. The Ministry of Health in Saudi Arabia should develop a more systematic way and adapt policies to gather cancer information in general, and head and neck cancer in particular, from all governmental and private sectors from all over the kingdom, and develop educational programs to raise the knowledge and awareness of HNC in the country.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
p16 - a Possible Surrogate Marker for High-Risk Human Papillomaviruses in Oral Cancer?
4049
4057
33097
EN
Thanun
Sritipph
Surawut
Pongsiriwet
Nirush
Lertprasertsuke
Kittisak
Buddhachat
Thanapat
Sastraruji
Anak
Iamaroon
Journal Article
1970
01
01
<span style="text-decoration: underline;"><span style="font-size: small;">Background</span></span><span style="font-size: small;">: High-risk human papillomaviruses (HR-HPV), particularly types 16 and 18, have been found to play an important role in head and neck cancer, including oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC). p16, a cell cycle inhibitor, has been postulated as a surrogate marker for HR-HPV, since p16 is aberrantly overexpressed in such lesions, especially in HR-HPV-positive OPSCC. However, p16 as a surrogate marker for HR-HPV infection in cancers of the oral cavity remains controversial. <span style="text-decoration: underline;">Objective</span>: The objectives of the study were to investigate the expression of p16 and the presence of HR-HPV in OSCC and oral verrucous carcinoma (VC) and to determine if p16 could be used as a surrogate marker for HR-HPV. <span style="text-decoration: underline;">Materials and Methods</span>: Forty one formalin-fixed, paraffin-embedded tissues of OSCC (n=37) or VC (n=4) with clinical and histopathologic data of each case were collected. Expression of p16 was determined by immunohistochemistry, focusing on both staining intensity and numbers of positive cells. The presence of HPV types 16 and 18 was detected by polymerase chain reaction (PCR). Descriptive statistics were employed to describe the demographic, clinical, and histopathologic parameters. Associations between p16 overexpression, HR-HPV and all variables were determined by Fisher’s exact test, odds ratios (ORs) and corresponding 95% confidence intervals (CIs). In addition, the use of p16 as a surrogate marker for HR-HPV was analyzed by sensitivity and specificity tests. <span style="text-decoration: underline;">Results</span>: p16 was overexpressed in 8/37 cases (21.6%) of OSCC and 2/4 cases (50%) of VC. HPV-16 was detected in 4/34 OSCC cases (11.8%) and HPV-18 was detected in 1/34 OSCC cases (2.9%). Co-infection of HPV-16/18 was detected in 1/4 VC cases (25%). Both p16 overexpression and HR-HPV were significantly associated with young patients with both OSCC and VC (p<0.05, OR 20, 95% CI 1.9-211.8; p<0.05, OR 23.3, 95% CI 2.4-229.7, respectively). p16 was able to predict the presence of HPV-16/18 in OSCC with 40% sensitivity and 79.3% specificity and in VC with 100% sensitivity and 66.7% specificity, respectively. <span style="text-decoration: underline;">Conclusions</span>: p16 overexpression was found in 24.4% of both OSCC and VC. HR-HPV, regardless of type, was detected in 15.8% in cases of OSCC and VC combined. The results of sensitivity and specificity tests suggest that p16 can be used as a surrogate marker for HR-HPV in OSCC and VC. </span>
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
BRCA1 and ТР53 Gene-Mutations: Family Predisposition and Radioecological Risk of Developing Breast Cancer
4059
4062
33098
EN
Bakytbek
Apsalikov
emey State Medical University, Semey, Republic of Kazakhstan, , Novosibirsk, The Russian Federation
Zukhra
Manambaeva
Erlan
Ospanov
Meruyert
Massabayeva
Kuantkan
Zhabagin
Zhanar
Zhagiparova
Vladymir
Maximov
Elena
Voropaeva
Kazbek
Apsalikov
Tatiana
Belikhina
Ramil
Abdrahmanov
Elena
Cherepkova
Sayat
Tanatarov
Adilzhan
Massadykov
Naylia
Urazalina
Journal Article
1970
01
01
<span style="font-size: small;">Frequencies of polymorphisms of genes BRCA1 and ТР53 in breast cancer (BC) patients with a BC family history and radiation history were assessed and compared in the Semey region of Kazakhstan. The study included 60 women directly irradiated by the activities of the Semipalatinsk test site with a calculated effective equivalent dose of 500 mSv and their first generation descendants (group BC+Her+Exp); 65 women with family BC and absence of radiological history - the effective equivalent dose due to anthropogenic sources not exceeding 50 mSv (group BC+Her-Exp). The comparison group consisted of 65 women patients with breast cancer without family and radiological history (BC-Her-Exp). The control group comprised 60 women without breast cancer and without family and radiological history (nonBC). We carried out the genotyping of the polymorphisms c.2311T>C, c.4308T>C and 5382insC of the BRCA1 gene and rs1042522 of the ТР53 gene. The frequency of the polymorphism c.2311T>C was significantly higher in patients of the group BC+Her+Exp than in healthy women, and of the polymorphism 5382insC in BC+Her+Exp compared to all other groups. The frequency of the rs1042522 polymorphism of ТР53 was significantly higher in all groups of patients with breast cancer compared with the control group. Differences between groups of women with breast cancer were significant only in BC+Her+Exp vs. BC+Her-Exp. Combinations of polymorphisms of the genes BRCA1 and TP53 predominated in women with a family and radiological history. </span>
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population
4063
4070
33100
EN
Kenichi
Kakino
Evaluation Center of Health and Nutrition Inc, Yamato-machi, Kasuga, Japan
Chikako
Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Takahiko
Horiuchi
Yoichi
Nakanishi
Journal Article
1970
01
01
Background Cytochrome P450 2E1 (CYP2E1) and catechol-O-methyltransferase (COMT) genes may contribute to susceptiblity to lung cancer becuase of their critical involvement in mechanisms of carcinogenesis. Materials and Methods We evaluated the role of CYP2E1 rs2031920 and COMT rs4680 in a case-control study involving 462 lung cancer cases and 379 controls in Japanese. Logistic regression was used to assess adjusted odds ratios (OR) and 95% con dence intervals (CI). Multiplicative and additive interactions with cigarette smoking or alcohol use were also examined. Results Neither CYP2E1 rs2031920 nor COMT rs4680 was associated with lung cancer risk overall. However, smokers with the CC genotype of CYP2E1 rs2031920 (OR 3.57, 95% CI 2.26-5.63) presented a higher risk of lung cancer than those with at least one T allele (OR 2.91, 95% CI 1.70-4.98) as compared to never-smokers with at least one T allele (reference). Subjects with excessive drinking and the CC genotype of CYP2E1 rs2031920 had a signi cantly higher risk (OR2.22, 95% CI 1.39-3.56) than appropriate drinkers with at least one T allele. A similar tendency was observed between COMT rs4680 and either smoking or drinking habits. There were no multiplicative or additive interactions between the polymorphisms and either smoking or alcohol use. Conclusions Our ndings indicate that CYP2E1 rs2031920 and COMT rs4680 are not major contributors to lung cancer risk in our Japanese population. Future studies on the genetics of lung cancer in Japanese and their environment interactions are required.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Value of FDG PET/Contrast-Enhanced CT in Initial Staging of Colorectal Cancer - Comparison with Contrast-Enhanced CT
4071
4075
33101
EN
Anchisa
Kunawudhi
National Cyclotron and PET Centre, Division of Nuclear Medicine, Chulabhorn Hospital, Thailand
Karun
Sereeborwornthanasak
Chetsadaporn
Promteangtrong
Bunchorn
Siripongpreeda
Saiphet
Vanprom
Chanisa
Chotipanich
Journal Article
1970
01
01
Background FDG PET/CT is at an equivocal stage to recommend for staging of colorectal cancer as compared to contrast-enhanced CT (ceCT). This study was intended to evaluate the value of FDG PET/ceCT in colorectal cancer staging as compared to ceCT alone. Materials and Methods PET/ceCT was performed for 61 colorectal cancer patients who were prospectively enrolled in the study. Three patients were excluded due to loss to follow-up. PET/ceCT ndings and ceCT results alone were read seperately. The treatment planning was then determined by tumor board consensus. The criteria for T staging were determined by the ndings of ceCT. Nodal positive by PET/ceCT imaging was determined by visual analysis of FDG uptake greater than regional background blood pool activity. The diagnostic accuracy of T and N staging was determined only in patients who received surgery without any neoadjuvant treatment. Results Of 58 patients, there were 40 with colon cancers including sigmoid cancers and 18 with rectal cancers. PET/ceCT in pre-operative staging detected bone metastasis and metastatic inguinal lymph nodes (M1a) that were undepicted on CT in 2 patients (3%), clearly de ned 19 equivocal lesions on ceCT in 18 patients (31%) and excluded 6 metastatic lesions diagnosed by ceCT in 6 patients (10%). These resulted in alteration of management plan in 15 out of the 58 cases (26%) i.e. changing from chemotherapy to surgery (4), changing extent of surgery (9) and avoidance of futile surgery (2). Forty four patients underwent surgery within 45 days after PET/CT. The diagnostic accuracy for N staging with PET/ceCT and ceCT alone was 66% and 48% with false positive rates of 24% (6/25) and 76% (19/25) and false negative rates of 47% (9/19) and 21% (4/19), respectively. All of the false negative lymph nodes from PET/ceCT were less than a centimeter in size and located in peri-lesional regions. The diagnostic accuracy for T staging was 82%. The sensitivity of the peri-lesional fat stranding sign in determining T3 stage was 94% and the speci city was 54%. Conclusions Our study suggested promising roles of PET/ceCT in initial staging of colorectal cancer with better diagnostic accuracy facilitating management planning.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Talin-1 and Non-invasive Fibrosis Models in the Assessment of Patients with Hepatocellular Carcinoma
4077
4082
33102
EN
Ayman
Alsebaey
Department of Clinical pathology, Faculty of medicine, Menoufia University, Shebeen El-Kom, Egypt
0000-0003-3781-2312
Iman
Ahmedy
Journal Article
1970
01
01
Background Hepatocellular carcinoma (HCC) is a dreadful complication of end stage liver disease with high morbidity and mortality. Aim The aim is to assess the role of serum talin-1 and non-invasive brosis in patients with HCC. Materials and Methods A total of eighty seven subjects were enrolled, 22 two healthy individuals as a control group (n22), 22 patients in the cirrhosis group and nally 43 in the group with HCC diagnosed with positive triphasic CT abdomen criteria. Serum talin-1 and noninvasive brosis parameters were assessed in all subjects. Results Compared to the cirrhosis group, patients with HCC had higher serum talin-1 (32.912.6 vs. 11.12.79 ng/ml), FIB4 (9.9615.3 vs. 2.901.87) and bro- (10.918.1 vs. 1.550.28) but not brosis index scores (4.470.95 vs. 4.980.96; p0.046). Patients with large focal lesions (5cm) had different ALBI scores (-1.020.63 vs. -1.720.59; p0.001) serum talin-1 (9.7213.81 vs. 28.638.89 ng/ml; p0.007) and brosis index scores (0.85 0.99 vs. 4.204.85; p0.026). No statistical differences were noted between patients with and without portal vein thrombosis. For detection of HCC, serum talin-1 had 97.7% sensitivity and 100% speci city with a 17.2 ng/ml cutoff. AFP at a 13.7 ng/ml cutoff had 72.1% sensitivity and 6.3.6% speci city. The cutoff for the bro- score was 1.61 with 81.4% sensitivity and 77.3% speci city. Serum talin-1 (odds1.08; C.I1.016-1.150; p0.014), brosis index score (odds2.35; C.I1.055-5.217; p0.037) and the ALBI score (odds6.9; C.I1.924-24.708; p0.003) were predictors of large focal lesions. Conclusions Serum talin-1, AST/ALT ratio, bro- score are useful for the assessment of HCC patients.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Lifetime Physical Activity and Breast Cancer a Case-Control Study in Kelantan, Malaysia
4083
4088
33103
EN
Siew Hwa
Yen
School of Distance Education, Universiti Sains Malaysia
A
Knight
MBV
Krishna
WMW
Muda
AA
Rufai
Journal Article
1970
01
01
Background Physical inactivity has been identi ed as the fourth leading risk factor for global mortality and is associated with increased breast cancer diagnosis and recurrence. Purpose To examine the association between adult lifetime physical activity and breast cancer risk in a case-control analysis. Materials and Methods This study involved 122 cases of breast cancer and 121 controls in the state of Kelantan in Malaysia. A comprehensive measure of lifetime physical activity was used to assess occupational, household, and recreational/sports activity. For every type of activity, a metabolic equivalent (MET) score was assigned using the compendium of physical activities. MET-hours/week per year for all types of activities at different levels of intensities for different age groups were calculated. Logistic regression analysis was used to estimate odds ratios between various measures of physical activity and breast cancer risk. Conclusions The mean MET-hours/week per year for all activities were 120.0 and 132.9 of MET-hours/week per year for cases and controls respectively. Household activities accounted about 70% of the total lifetime physical activities. Only about 2.5% of the total lifetime physical activities were in the form of recreational/sports. This study found no association between lifetime occupational and recreational/sports physical activities with breast cancer risk among the Kelantanese women. However, higher intensity lifetime household activities seemed to signi cantly reduce risk of breast cancer.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Predictive Value of the Pattern of -Catenin Expression for Pathological Response to Neoadjuvant Chemotherapy in Breast Cancer Patients
4089
4093
33104
EN
S
Elsamany
Oncology, King Abdullah Medical City, Makkah, Saudi Arabia
O
Elemam
S
Elmorsy
A
Alzahrani
MM
Abbas
Journal Article
1970
01
01
Purpose This study aimed to explore the association of -catenin expression pattern with pathological response after neoadjuvant chemotherapy in breast cancer (BC) patients. Materials and Methods In this retrospective exploratory study, data for 50 BC patients who received neoadjuvant chemotherapy were recorded. -catenin expression in tumours was assessed using immunohistochemistry and classi ed as either membranous or cytoplasmic according to the pattern of staining. Distributions of different clinico-pathological parameters according to -catenin expression were assessed using the Chi-square test. Logistic regression analysis was used to assess any relation of the pattern of -catenin expression with the pathological response. Results Cytoplasmic -catenin expression was detected in 34% of BCs. Among our cases, 52% were hormonal receptor (HR)-positive, 24% were HER2-positive, 74% were clinical stage III and 74% received both anthracycline and taxane-based chemotherapy. Patients with cytoplasmic expression were more commonly younger than 40 years at diagnosis (cytoplasmic, 41.2% vs. no cytoplasmic expression, 12.1%, p0.03). By doing t-test, cytoplasmic -catenin expression was linked with a higher body mass index compared to membranous-only expression (mean SD 33.0 4.47 vs. 29.6 6.01, respectively, p0.046). No signi cant associations were found between -catenin expression and other parameters such as HR and HER2 status, or clinical stage. Complete pathological response (pCR) rate was twice as great in patients with membranous expression but without statistical signi cance (membranous- only, 33.3% vs. cytoplasmic, 17.6%, OR2.3, 95% CI 0.55-9.87, p0.24). Conclusions This study suggests that cytoplasmic -catenin expression may be linked with lower probability of achieving pCR after neoadjuvant chemotherapy. These data needs to be validated in a larger cohort of patients.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Spiritual/Religious Coping Strategies and their Relationship with Illness Adjustment among Iranian Breast Cancer Patients
4095
4099
33105
EN
Roghieh
Khodaveirdyzadeh
Medical-Surgical Department, Nursing and Midwifery faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Rabee
Rahimi
Azad
Rahmani
Akram
Ghahramanian
Naser
Kodayari
Jamal
Eivazi
Journal Article
1970
01
01
Background Use of spiritual/ religious resources is one important coping strategy of breast cancer patients. However, the relationship between spiritual coping and adjustment to cancer diagnosis has not been well investigated among Iranian breast cancer patients. Materials and Methods This descriptive-correlational study was undertaken among 266 breast cancer patients referred to two educational centers in north-western Iran. They were selected using a convenience sampling method. The Iranian Religious Coping Scale and Iranian Coping Operations Preference Enquiry were used for data collection. The data were analyzed using SPSS version 13.0. Results The study ndings showed that Iranian cancer patients had a high level of spiritual coping. Also, positive religious coping strategies were used more frequently than negative approaches. In addition, there was a positive and signi cant correlation between spiritual coping and adjustment to cancer among study participants. Conclusions Using spiritual coping strategies may play a vital role in adjustment process in patients with breast cancer. Therefore, having spiritual counseling and incorporating coping strategies into the treatment regimen may be effective for enhancing illness adjustment in such patients.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Colorectal Cancer Mortality in Shiraz, Iran
4101
4105
33106
EN
Mostafa
Dianatinasab
Student Research Committee, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran
Haleh
Ghaem
Abbas
Rezaianzadeh
Seysd Vahid
Hosseini
Hajar
Khazraei
Journal Article
1970
01
01
Background Mortality among Iranian patients with colorectal cancer has not been fully examined and the factors associated with their survival are still controversial. This study aimed to determine the mortality rate and its related factors among the patients with colorectal cancer in southwestern regions in Iran. Materials and Methods This prospective cohort study was conducted on 220 patients with colorectal cancer referred to Fahighi Hospital, Shiraz, Iran from 2009 to 2014. Data were collected from the patients' medical records and were analyzed using Cox regression analysis. Results Over a median follow-up of 29.3 months, 56 out of the 220 patients (25.5%) died, 32 (14.5%) aged below 40 years, and 45.5% were female. Based on the results of multiple Cox regression analysis, family history of gastrointestinal cancer, stage III, former smoking, type of lesion (fungative and polypoid), and opium use were associated with a greater risk of colorectal cancer mortality (all <0.05). Conclusions This cohort study found that the mortality rate of colorectal cancer in Iran is lower than that in European countries. In addition, behavioral and clinical factors were signi cantly associated with the survival rate. Addressing the related factors would help healthcare providers and physicians provide the best care and improve the survival rate.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population
4107
4111
33107
EN
Sukumaran
Anil
Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, India
0000-0003-0373-0984
Gopikrishnan
PB
Ashik Bin
Basheer
Vidyullatha
BG
Yahya A
Alogaibi
Elna P
Chalisserry
Fawad
Javed
M H N
Dalati
Sajith
Vellappally
Mohamed Ibrahim
Hashem
Darshan Devang
Divakar
Journal Article
1970
01
01
Background Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is ve to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions. Several studies reported mixed effects on the association between PARP-1 variants and the risk of cancer development. Till now no reported studies have investigated the association between PARP-1 variants and oral squamous cell carcinoma (OSCC) risk in an Indian population. Materials and Methods In the present case control study 100 OSCC patients and 100 matched controls were genotyped using PARP1 Single nucleotide peptides (SNP's) rs1136410 and rs3219090 using TaqMan assays. Results The results indicated signi cantly higher risk with PARP1 rs1136410 minor allele "C" (OR1.909; p0.02942; CI, 1.060- 3.439). SNP rs1136410 also showed signi cantly increased risk in patients with smoking habit at C/C genotype and at minor allele C. Conclusions The PAPR-1 Ala762Val polymorphism may play a role in progression of OSCC. Larger studies with more number of samples are needed to verify these ndings.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Effectiveness of Acceptance and Commitment Therapy on Life Expectancy of Female Cancer Patients at Tehran's Dehshpour Institute in 2015
4113
4116
33108
EN
Farahnaz
Ghasemi
Student Research Committee, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran
Fateme
Dehghan
Vahid
Farnia
Faeze
Tatari
Mostafa
Alikhani
Journal Article
1970
01
01
<span style="text-decoration: underline;"><span style="font-size: small;">Background</span></span><span style="font-size: small;">: Acceptance and commitment therapy (ACT) increases the psychological flexibility of people afflicted with cancer, and consequently improves their adaptability. The present research was conducted with the aim of determining the effectiveness of ACT for people afflicted with cancer. <span style="text-decoration: underline;">Materials and Methods</span>: The present research was of semi-pilot type with a pre-test and post-test plan for the proof group. The demographics of the community were composed of all the women with cancer who were under treatment in Tehran’s Dehshpour therapeutic center in 2015. The sample was composed of 24 people who were selected as available and chosen randomly in two groups of test and proof. All the participants responded to Snyder questionnaire in two pre-test and post-test stages, and the test group participated in treatment sessions after conducting the pre-test. <span style="text-decoration: underline;">Results</span>: After collecting the information, data analysis was conducted in two description and inferential levels. The test results of covariance analysis showed that the two groups’ hope was meaningfully different. Hope in the test group, compared to the proof group, increased meaningfully. <span style="text-decoration: underline;">Conclusions</span>: The results show that the ACT is effective in increasing hope of patients with cancer. </span>
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Epithelial-speci c SHP1-P2 Methylation - a Novel Universal Tumor Marker for Detection of Colorectal Cancer Lymph Node Metastasis
4117
4123
33109
EN
Prakasit
Rattanatanyong
Center of Excellence in Molecular Genetics of Cancer and Human Disease, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Somboon
Keelawat
Nakarin
Kitkumthorn
Apiwat
Mutirangura
Journal Article
1970
01
01
Background Methylation of promoter 2 of the SHP1 gene is epithelial cell speci c, with reported potential as a lymph node metastatic marker. Objective To demonstrate SHP1-P2 methylation-speci c quantitative PCR effectiveness in detecting colorectal cancer (CRC) DNA in lymph nodes. Materials and Methods SHP1-P2 methylation levels were measured in lymph nodes of CRC patients and compared with pathological ndings and patient prognosis. Results Lymph nodes of CRC metastatic patients without microscopically detectable cancer cells had higher SHP1-P2 methylation levels than lymph nodes of controls (<0.001). In addition, a higher SHP1-P2 methylation level was associated with a shorter duration until adverse disease events, metastasis, recurrence and death (r2 0.236 and p value 0.048). Studying two cohorts of 74 CRC patients without microscopic lymph node metastases showed that only the cohort containing samples with high SHP1-P2 methylation levels had a signi cant hazard ratio of 3.8 (95%CI 1.02 to 14.2). Conclusions SHP1-P2 methylation PCR can detectCRC cancer DNA in lymph nodes even if cancer cells are not visible under a microscope, con rming it's potential universal lymph node metastatic marker.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer
4125
4129
33110
EN
Fateme
Sanaati
Department of Nursing, University of Wefare and Rehabilitation Sciences, Tehran, Iran
Safa
Najafi
Zahra
Kashaninia
Masoud
Sadeghi
Journal Article
1970
01
01
Background Chemotherapy-induced nausea and vomiting (CINV) places a signi cant burden on the patient. Herbal agents are the most commonly complementary therapies used among the public. This study was done to determine the effect of ginger and chamomile capsules on nausea and vomiting in chemotherapy for breast cnacer (BC). Materials and Methods In a randomized, double-blind and clinical trial study, 65 women with BC undergoing chemotherapy were referred to Breast Cancer Research Center, Tehran, Iran, between May 2013 to June 2014. Regimen for ginger group for 5 days before and 5 days after chemotherapy was 2 times a day and 500 mg capsules of powdered ginger root in addition to a routine antiemetic regimen consisting of dexamethasone, metoclopramide and aprepitant (DMA) capsules. Chamomile group similarly was 2 times a day and 500 mg capsules of Matricaria chamomilla extract in addition to a routine antiemetic regimen consisting of DMA capsules. Control group, routine antiemetic regimen consisting of DMA capsules. Results There were no signi cant differences between the ginger, chamomile and control groups regarding age. Drugs used for chemotherapy were identical and duration of disease was also matched (1-4 months). Ginger and chamomile were both signi cantly effective for reducing the frequency of vomiting, there being no signi cant difference between the ginger and chamomile groups. Moreover, unlike the chamomile, ginger effected signi cantly the frequency of nausea. Conclusions According to the ndings of this study, it should be declared that taking ginger capsules (1 g/day) might relieve CINV safely. Nurses dealing directly with cancer patients should be responsible for providing educational programs for patients and their families about how to deal with their drug regimens and its side effects.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Factors Associated with Periductal Fibrosis Daignosied by Ultrasonography Screening among a High Risk Population for Cholangiocarcinoma in Northeast Thailand
4131
4136
33111
EN
Sutheera
Intajarurnsan
Public Health Program, Faculty of Medicine, Khon Kaen University, Thailand
0000-0001-5787-1948
Narong
Khuntikeo
Nittaya
Chamadol
Bandit
Thinkhamrop
Supannee
Promthet
Journal Article
1970
01
01
Background The population in northeast Thailand continues to present with hepatobiliary abnormalities, particularly periductal fibrosis (PDF) which is the result of chronic infection with liver fluke (Opisthorchis viverini; OV) and may lead to the development of cholangiocarcinoma (CCA). Although the prevalence of OV infection has been decreased due to a liver fluke control program over decades, the prevalence of PDF remains high. This study aimed to investigate demographic factors associated with PDF risk based on ultrasonography (US) screening. Materials and Methods This cross-sectional study is part of the Cholangiocarcinoma Screening and Care Program (CASCAP), a prospective cohort study. Multiple logistic regression was used for data analysis. Results In 55,246 subjects, the overall prevalence of PDF was 33.0% (95%CI 32.6 - 33.4). Males (33.9 %) were at higher risk for developing PDF than females (32.2 %) (ORcrude 0.93; 95%CI 0.89 - 0.96; p-value < 0.001). Factors associated with an increased PDF risk, in addition to OV infection, included old age ( 70 years) (ORadj 1.28, 95% CI 1.14 - 1.44, <0.001) and hepatitis B infection (ORadj 1.31, 95% CI 1.11 - 1.55, p 0.001). In contrast, number of praziquantel treatments (> 2 times) (ORadj 0.54, 95% CI 0.47 - 0.63, <0.001) and diabetes mellitus (ORadj 0.57, 95% CI 0.49 - 0.65, <0.001) were significantly associated with a decreased PDF risk. Conclusions Future US screening should closely examine older people and hepatitis B subjects for the purpose of PDF surveillance among high risk groups for CCA. However, the results of inverse associations require further investigation in order to confirm our findings.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Breast Cancer Detection Rate, Incidence, Prevalence and Interval Cancer-related Mammography Screening Times among Thai Women
4137
4141
33112
EN
Nintita
Sripaiboonkij
Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Thailand
Bandit
Thinkamrop
Supannee
Promthet
Chalermdej
Kannawat
Voranuj
Tangcharoensathien
Tamnit
Ansusing
Suthee
Rattanamongkolgul
Journal Article
1970
01
01
Background A recent guideline by the American Cancer Society recommended that mammography (MMG) should be done for women starting in their mid-40s. In Thailand, information on opportunistic mammography screening is limited and data on the total incidence of breast cancer ares also lacking. The purpose of this study was to estimate the breast cancer detection, incident and Prevalence rates among Thai women. Materials and Methods We retrospectively reviewed the opportunistic mammography screening of normal women between 30 and 80 years who underwent the procedure between 2001 and 2010. All cases were followed until 2012. The detection rate was calculated for the whole period of observation using 'number of women with positive findings' divided by 'total number of women screened'. The incidence rate was calculated only at the first MMG while the subsequence rate was calculated based on all new cases detected at each subsequent MMG. Results Among the 47,430 women, there were 152,091 MMGs or approximately 3.2 occasions per person (range, 1-10). The average duration of the interval between each subsequence visit was 1.8 years. Overall, breast cancer was detected in 543 women, with a detection rate of 10.26 per 1,000 persons. The prevalence rate of breast cancer at the first visit was 5.78 per 1,000 persons. The incidence or new cases detected at any follow-up visit was 10.4 per 1,000 persons. The overall interval cancer was 0.91 per 1,000 women, mainly detected before their second and third MMG, with a rate of 0.0.47 and 0.76 per 1,000 women. Conclusions Opportunistic mammography screening in Thailand detected 10 case of breast cancer from every 1,000 women. This paper indicated a high rate of cancer detection during a two year interval, hence, a screening mammogram should be done more often.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Accuracy of FDG-PET/CT for Detection of Incidental Pre-Malignant and Malignant Colonic Lesions - Correlation with Colonoscopic and Histopathologic Findings
4143
4147
33113
EN
Anchisa
Kunawudhi
Division of Precision Medicine, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA
National Cyclotron and PET Centre, Chulabhorn Hospital, Bangkok,
Thailand
Alexandra K
Wong
Tarik K
Alkasab
Umar
Mahmood
Journal Article
1970
01
01
<span style="text-decoration: underline;"><span style="font-size: small;">Purpose</span></span><span style="font-size: small;">: We evaluated all PET/CTs acquired for patients without a primary diagnosis of colorectal cancer, and compared results for those who had subsequent colonoscopy within 6 months, to assess the accuracy of FDG PET/CT for detection of incidental pre-malignant polyps and malignant colon cancers. <span style="text-decoration: underline;">Materials and Methods</span>: Medical records of 9,545 patients who underwent F-18 FDG PET/CT studies over 3.5 years were retrospectively reviewed. Due to pre-existing diagnosis of colorectal cancer, 818 patients were excluded. Of the remainder, 157 patients had colonoscopy within 6 months (79 males; mean age 61). We divided the colon into 4 regions and compared PET/CT results for each region with colonoscopy and histopathologic findings. True positive lesions included colorectal cancer, villous adenoma, tubulovillous adenoma, tubular adenoma and serrated hyperplastic polyp/hyperplastic polyposis. <span style="text-decoration: underline;">Results</span>: Of 157 patients, 44 had incidental colonic uptake on PET/CT (28%). Of those, 25 had true positive (TP) uptake, yielding a 48% positive predictive value (PPV); 9% (4/44) were adenocarcinoma. There were 23 false positive (FP) lesions of which 4 were hyperplastic polyp, one was juvenile polyp and 7 were explained by diverticulitis. Fifty eight patients had false negative PET scans but colonoscopy revealed true pre-malignant and malignant pathology, yielding 23% sensitivity. The specificity, negiative predictive value (NPV) and accuracy were 96%, 90% and 87%, respectively. The average SUVmax values of TP, FP and FN lesions were 7.25, 6.11 and 2.76, respectively. There were no significant difference between SUVmax of TP lesions and FP lesions (p>0.95) but significantly higher than in FN lesions (p<0.001). The average size (by histopathology and colonoscopy) of TP lesions was 18.1 mm, statistically different from that of FN lesions which was 5.9 mm (p<0.001). Fifty-one percent of FN lesions were smaller than 5 mm (29/57) and 88% smaller than 10 mm (50/57). <span style="text-decoration: underline;">Conclusions</span>: The high positive predictive value of incidental focal colonic FDG uptake of 48% for colonic neoplasia suggests that colonoscopy follow-up is warranted with this finding. We observed a low sensitivity of standardly acquired FDG-PET/CT for detecting small polyps, especially those less than 5 mm. Clinician and radiologists should be aware of the high PPV of focal colonic uptake reflecting pre-malignant and malignant lesions, and the need for appropriate follow up. </span>
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Promoter Methylation and Relative mRNA Expression of the p16 Gene in Cervical Cancer in North Indians
4149
4154
33191
EN
Amita
Gupt
Mohammad Kaleem
Ahmad
Abbas Ali
Mahndi
Renu
Singh
Yashodhara
Pradeep
Journal Article
1970
01
01
<span style="text-decoration: underline;"><span style="font-size: small;">Background</span></span><span style="font-size: small;">: Cervical carcinoma is one of the main causes of mortality in women worldwide as well as in India. It occurs as a result of various molecular events that develop from the combined influences of an individual’s genetic predisposition and external agents such as smoking and menstrual hygiene, for example. However, infection with human papillomavirus (HPV) is the established major risk factor. The aim of the current study was to investigate p16 CpG island methylation and establish any correlation with mRNA expression in north Indian population. <span style="text-decoration: underline;">Materials and Methods</span>: We analyzed 196 woman volunteer out of which 98 were cases and 98 healthy controls. For the analysis of methylation pattern, DNA extracted from blood samples was modified with a bisulfate kit and used as template for methylation specific PCR (MSP). Quantitative real-time PCR (QRT-PCR) was performed to check mRNA expression. <span style="text-decoration: underline;">Results</span>: Correlation between methylation status of p16 gene and poor menstrual hygiene was significant (p=0.006), high parity cases showed methylation of p16 gene (p=0.031) with increased risk up to 1.86 times for cervical cancer and smoking was a strong risk factor associated with cervical cancer. We analyzed methylation pattern and found 60.3% methylation in cases with low mRNA expression level (0.014) as compare to controls (1.24). It was also observed that promoter methylation of p16 gene was significantly greater in FIGO stage III. <span style="text-decoration: underline;">Conclusions</span>: We conclude that p16 methylation plays an important role in cervical cancer in the north Indian population and its methylation decreases mRNA expression. It can b e used as an important and consistent blood biomarker in cervical cancer patients. </span>
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Plasma Lipidomics as a Tool for Diagnosis of Extrahepatic Cholangiocarcinoma in Biliary Strictures a Pilot Study
4155
4161
33114
EN
Varayu
Prachayakul
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Phataraphong
Thearavathanasingha
Chanitra
Thuwajit
Sittiruk
Roytrakul
Janthima
Jaresitthikunchai
Journal Article
1970
01
01
Biliary obstruction is a common clinical manifestation of various conditions, including extrahepatic cholangiocarcinoma. However, a screening test for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction is not yet available. According to the rationale that the biliary system plays a major role in lipid metabolism, biliary obstruction may interfere with lipid profiles in the body. Therefore, plasma lipidomics may help indicate the presence or status of disease in biliary obstruction suspected extrahepatic cholangiocarcinoma. This study aimed to use of plasma lipidomics for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction. Plasma from healthy volunteers, patients with benign biliary obstruction extrahepatic cholangiocarcinoma, and other related cancers were used in this study. Plasma lipids were extracted and lipidomic analysis was performed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Lipid profiles from extrahepatic cholangiocarcinoma patients showed significant differences from both normal and benign biliary obstruction conditions, with no distinction between the latter two. Relative intensity of the selected lipid mass was able to successfully differentiate all extrahepatic cholangiocarcinoma samples from patient samples taken from healthy volunteers, patients with benign biliary obstruction, and patients with other related cancers. In conclusion, lipidomics is a non-invasive method with high sensitivity and specificity for identification of extrahepatic cholangiocarcinoma in patients with biliary obstruction.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Prevalence and Risk Assessment of Cervical Cancer Screening by Papanicolaou Smear and Visual Inspection with Acetic acid of Pregnant Women at a Thai Provincial Hospital
4163
4167
33115
EN
Jiraporn
Lertcharernrit
Department of Obstetrics and Gynecology,Prapokklao Hospital, Chanthaburi, Thailand
Panya
Sananpanichkul
Wineeya
Suknikhom
Kornkarn
Bhamarapravatana
Komsun
Suwannarurk
Yosapon
Leaungsomnapa
Journal Article
1970
01
01
Background Cervical cancer is the second most common in Thailand, but the mortality rate may be rising yearly. It is a cancer that can be prevented by early screening for precancerous lesions, several methods being available. Objective To identify the prevalence of abnormal Papanicolaou (Pap) smears and lesions with visual inspection with acetic acid (VIA) in pregnant women and assess risk factors for this group. Materials and Methods This prospective study was performed at Prapokklao Hospital, Thailand during April-July 2016. All pregnant women of gestational age between 12-36 weeks who attended antenatal clinic were recruited. All participants were screened for cervical cancer by Pap smear and VIA. If results of one or both were abnormal, colposcopic examination was evaluated by gynecologic oncologist. Results A total of 414 pregnant women were recruited. Prevalence of abnormal Pap smear and VIA were 6.0 and 6.7 percent, respectively. The most common abnormal Pap smear was low grade intraepithelial lesion (LSIL, 44%). Factor associated with abnormal Pap smear in pregnant women were low BMI, multiple partners and government officer. In pregnancy, Pap smear had higher sensitivity and specificity than VIA for detection of precancerous cervical lesion. Patients with young coitarche or more than 25 years of active sexual activity were high risk groups. Conclusions Prevalence of abnormal Pap smear and VIA in pregnant women was 6.0 and 6.7 percent, respectively. Factors associated with abnormal Pap smear were coitarche, years of sexual activity, low BMI, multiple partners and government officer.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Mesotheliomas in Lebanon Witnessing a Change in Epidemiology
4169
4173
33117
EN
Joseph
Kattan
Department of Hematology-Oncology, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Roland
Eid
Hampig Raphael
Kourie
Fadi
Farhat
Marwan
Ghosn
Claude
Ghorra
Roland
Tomb
Journal Article
1970
01
01
Background Mesotheliomas are relatively rare tumors in Lebanon The only previous study goes back to 14 years ago when we published epidemiological characteristics of mesotheliomas in Lebanon showing that the pleural location accounted for the vast majority of cases with a clear evidence of asbestos exposure from the Eternit factory of Chekka region The objective of this current study was to estimate the incidence of mesothelioma in the past decade and to identify its epidemiological clinical and therapeutic characteristics making comparisons with our first study published in 2001 Materials and Methods Between 2002 and 2014 patients diagnosed with malignant mesothelioma at HotelDieu de France University Hospital were investigated Epidemiological data focusing on asbestos exposure history were collected from medical records and interviews with the families Results A total of 26 patients were diagnosed with mesothelioma 21 of which were successfully investigated. The mean age of these 21 patients is 625 (1982) Only 3 (1429) are women 18 (8571) were smokers Among the 21 available mesotheliomas 15 (714) are pleural while 5 (238) are peritoneal and 1 (48) pericardial Only 60 of patients with pleural mesothelioma and 50 of those with an obvious exposure to asbestos lived andor worked in Chekka region The mean time of asbestos exposure in patients with mesothelioma is 245 (150) years and the mean latency is 374 (461) years Of the 21 patients 10 (476) underwent surgery during their treatment 16 (762) received chemotherapy and 3 (143) received best supportive care Conclusions Compared to the previous study (19912000) substantial changes in the epidemiology of mesothelioma in Lebanon were observed such as an increase in peritoneal localizations and a lower correlation with Chekka region asbestos contamination
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Prevalence and Factors Associated with Oral Pre-malignant Lesions in Northeast Thailand
4175
4179
33116
EN
Narongrit
Juntanong
Dental Department, Roi-et Hospital, Roi-et Province, Thailand
0000-0001-5787-1948
Pallop
Siewchaisakul
Peter
Bradshaw
Patravoot
Vatanasapt
Sam Li-Sheng
Chen
Amy Ming-Fang
Yen
Tony Hsiu-Hsi
Chen
Supannee
Promthet
Journal Article
1970
01
01
Background Oral cavity cancer (OCC) is one of the most common cancers worldwide. No studies have reported on the prevalence and epidemiologic risk factors of oral premalignant lesions (OPLs) in Thailand. The purpose of this study was to investigate the prevalence of OPLs and associated factors in Roi Et Province, Thailand. Materials and Methods To investigate the prevalence of OPLs, a cross-sectional descriptive study was conducted in which 2,300 subjects over 40 years of age were recruited and screened for the prevalence of OPLs. To identify factors associated with OPLs, a matched case-control study was used in which the subjects were 102 cases with OPL and 102 matched controls without OPLs. The studies were conducted in Roi Et Province during the period 1 February, 2014, to 30 April, 2014, and the data were collected by the use of a structured interview questionnaire and by the extraction of information from medical records. Data analyses involved the use of descriptive statistics, McNemar's test, and conditional logistic regression. Results The overall prevalence of OPLs was 3.8%, and no-one was diagnosed with more than one type of OPL. The factors found to be associated with a statistically significant higher risk of an OPL were betel nut chewing, smoking, and alcohol consumption. The associations with these factors were strong, especially for betel nut chewing and smoking. Conclusions The habits of betel nut chewing, smoking, and alcohol use are confirmed as factors associated with OPLs in a population of Roi Et Province, Thailand. Campaigns to reduce these risk healthy behaviours are needed, but whether any decrease in these behaviours will prevent the eventual transformation of an OPL into an OCC remains an open question.
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Increased Trend of Haematological Malignancies in Kurdistan Region/Iraq
4181
4182
33118
EN
Ramadhan T
Othman
Department of Internal Medicine, Faculty of Medical Sciences, University of Duhok, Duhok, Iraq
Nawfal R
Hussein
Journal Article
1970
01
01
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
17
8
2016
08
01
Role of Digital Infrared Thermal Imaging in Radiation Therapy Planning and Toxicity
4183
4184
33119
EN
Yasemin Benderli
Cihan
Kayseri Education and Research Hospital, Department of Radiation Oncology, Turkey
Talha
Sarigoz
Journal Article
1970
01
01