Cancer Research Advances Regarding the CKLF-like MARVEL Transmembrane Domain Containing Family

Document Type: Systematic Review and Meta-analysis

Authors

1 School of Basic Medical,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

2 School of Stomatology,The Fourth Hospital of Hebei Medical University , Shijiazhuang, Hebei, China

3 School of Public Health,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

4 Department of Blood Transfusion,The Fourth Hospital of Hebei Medical University,Shijiazhuang, Hebei,China

5 Department of Pathology, The Second Hospital of Hebei Medical University,Shijiazhuang, Hebei,China

6 Department of Clinical Laboratory, The Third Affiliated Hospital, Shijiazhuang, Hebei,China

7 Department of Immunology,Hebei Medical University

8 Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China

9 Department of Surgical Oncology, Chinese PLA General Hospital, Beijing, China

Abstract

The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products act between chemokines and the transmembrane-4 superfamily. Located in several human chromosomes, the CMTMs CKLF and CMTM1 to CMTM8 may be unregulated in tumors and act as potential tumor suppressor genes with important roles in the immune, male reproductive and hematopoietic systems. In-depth studies in recent years established a close relation between CMTMs and tumorigenesis and metastasis. The CMTM family has a significant clinical value in diagnosis and treatment of diseases linked to tumors and the immune system.

Keywords