No Association of Cytochrome P450-1B1 Gene Polymorphisms with Risk of Breast Cancer: an Egyptian Study

Document Type: Systematic Review and Meta-analysis

Authors

1 Department of Clinical and Chemical Pathology, National Research Center,Cairo University, Cairo, Egypt.

2 Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.

3 Biochemistry and Molecular Medicine Department, College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

4 Department of Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.

5 Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.

Abstract

It is thought that population characteristics of breast cancer may be due to a variation in the frequency of different alleles of genes such as CYP1B1. We aimed to determine the association of CYP1B1 polymorphisms in 200 breast cancer cases and 40 controls by PCR-RFLP. Frequencies were assessed with clinical and risk factors in Egyptian patients. The genotype LV and the Leu allele frequencies for patients and controls were 42.9% and 50%, and 52.9% and 53.3%, respectively), with no significant differences observed (P values = 0.8 and 0.6, respectively). There was also no significant association between genotypes and any risk factors for cases (P>0.05) except laterality and metastasis of the tumor (P values=0.006 and 0.06, respectively). The CYP1B1 polymorphism Val432Leu was not associated with breast cancer in Egypt, but may provide clues for future studies into early detection of the disease.

Keywords