Possible Epithelial Ovarian Cancer Association with HPV18 or HPV33 Infection

Document Type : Systematic Review and Meta-analysis


1 Jishou University, Datianwan, Jishou, China

2 Equal contributors

3 Hunan Normal University, Changsha, China

4 Maternal and Child health Hospital of Hunan, Changsha, China

5 Hunan Cancer Hospital, Changsha, China


The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data. The prevalence of HPV18 and HPV33 in EOC group and benign group was higher than in the normal group. HPV18 and HPV33 may play a role in the development of both EOC and ovarian benign tumor and may participate in the development of EOC with traditional risk factors, family history and abortion, possibly exerting synergistic effects.