Objective: To survey the role of Helicobacter pylori at the tissue level as a cause of squamous cell carcinomaof the larynx. Design:A case-control study. Setting: In an Otolaryngology Ward at an academic university.Subjects: Patients with laryngeal cancer as cases and patients with benign laryngeal lesion as controls. Mainoutcome measure: In all subjects, specimens of laryngeal tissue were examined by rapid urease test whilehistopathologic examination was achieved to detect H. Pylori.
Results: Totally, 44 patients (42 men and 2 women)with squamous cell carcinoma of larynx and 30 patients (24 men and 6 women) with benign laryngeal lesions(polyp, nodule, granuloma) were studied, none of which were infected with the bacterium.
Conclusion: Ourresults did not show H. Pylori infection among patients with laryngeal cancer (SCC) or benign laryngeal lesions.