Prevalence of High Grade Squamous Intraepithelial Lesion (HSIL) and Invasive Cervical Cancer in Patients with Low Grade Squamous Intraepithelial Lesion (LSIL) at Cervical Pap Smear

Objective: To assess the prevalence and factors associated with a histologic diagnosis of high grade squamousintraepithelial lesion (HSIL) and invasive cervical cancer in patients with low grade squamous intraepitheliallesion (LSIL) cervical pap smear findings.
Methods: Medical records (including cytology reports, colposcopicimpression, and pathologic results from cervical biopsy, endocervical curetting, cervical conization orhysterectomy) of 226 women with LSIL from conventional cervical pap smears during January 2001 to December2005, who subsequently underwent colposcopic evaluation at our institution, were reviewed.
Results: Mean ageof the patients was 39.0 years. The incidences of LSIL, HSIL, microinvasive cervical cancer were 58.8%, 15.0%,1.3% respectively. No associations were found between age, parity, contraception, anti-HIV or menstrual statusand the detection of HSIL/invasive cervical cancer.
Conclusion: Approximately 16.3 % of LSIL pap smear casesturn out to be HSIL or invasive cervical cancer from histologic diagnosis.