The population-based Aden Cancer Registry (ACR) started its activities in 1997. The objective of the registryis to establish a reliable magnitude of cancer in the area covered and the first report was published in 2003. Thepresent article describes data from the second report of cancer incidence over a five year period (2002-2006).Internationally accepted standardized cancer registration methodologies described by IACR and IARC wereused. CanReg-4 using ICDO-3 and ICD-10 were applied in the data processing and analysis. Results showed nodifference in the overall incidence between the males and females (ratio was 0.83:1) and age standardized rates(ASR) per 100,000 inhabitants were 30.2 and 31.1. The five most common cancers were breast cancer, leukemia,non-Hodgkin’s lymphomas (NH lymphoma), brain cancer and Hodgkin’s disease (16.6%, 12.6%, 7.8%, 5.2%and 4.4%, respectively). Among males, leukemia was the first followed by NH lymphoma, Hodgkin’s disease,brain and liver. In females, breast was the first, then leukemia, NH lymphoma, thyroid and brain cancer. Thehighest ASR for males (145 per 100,00 inhabitants) was observed at age 70-74 years whereas for females, twopeaks (each 105 per 100,000 inhabitants) were equally noticed at age 60-64 and 70-74 years. Generally, femalesshowed equal or higher incidence compared to males until age 55-59 where males reported higher incidence.The overall pattern of cancer incidence in this report is not much different from that in the previous report.Furthermore, the report generally indicates that the pattern of the most common registered cancer bears somesimilarities with the adjacent Gulf Cooperation Council States with which we share many charactristics, despitedifferences that warrant further invistigation.