Background: The aim of this study was to estimate some prognostic factors that affect on overall survival ofpatients with early gastric cancer. Methods: A retrospective study had been done on patients diagnosed withearly gastric cancer who registered in cancer registry center, Tehran-Iran, between December 21, 2001 andDecember 21, 2006 and all patients were followed by telephone contacts. The Kaplan-Meier method was performedto describe survival curves and log-rank test to compare the survival rate in subgroups. Cox regression wasused to determine the prognosis factors. Results: The mean age was 57.9 ± 11.9 years and 72.6% of patientswere male. Tumor size (>35mm) and lymph node metastasis were established as significant factors for survivalof patients with EGC in both univariate and multivariate analysis. Conclusion: The findings of this studyindicate that lymph node metastasis and tumor size are the most independent prognostic factors in these patients.