Utilizing basic concepts of chemical carcinogenesis and the human relevance framework based on mode of action analysis of animal carcinogens, an alternative is proposed for the two-year bioassay for screening chemicals for potential carcinogenic risk in humans. This model includes short-term screening of chemicals for DNA reactivity, immunosuppressive and, estrogenic activity, and potential increased cell proliferation. Follow-up studies can provide detailed information with regard to dose response and mode of action, with a detailed evaluation of potential relevance to humans. It is no longer appropriate to continue performing two year rodent bioassays.
(2010). An Enhanced Thirteen-Week Bioassay as an Alternative for Screening for Carcinogenesis Factors. Asian Pacific Journal of Cancer Prevention, 11(1), 15-17.
MLA
. "An Enhanced Thirteen-Week Bioassay as an Alternative for Screening for Carcinogenesis Factors". Asian Pacific Journal of Cancer Prevention, 11, 1, 2010, 15-17.
HARVARD
(2010). 'An Enhanced Thirteen-Week Bioassay as an Alternative for Screening for Carcinogenesis Factors', Asian Pacific Journal of Cancer Prevention, 11(1), pp. 15-17.
VANCOUVER
An Enhanced Thirteen-Week Bioassay as an Alternative for Screening for Carcinogenesis Factors. Asian Pacific Journal of Cancer Prevention, 2010; 11(1): 15-17.
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