The countries of mainland South-East Asia, Myanmar, Thailand, Laos, Cambodia and Viet Nam, share along history of interactions and many cultural similarities, as well as geographical contiguity. They thereforecan be usefully examined as a group when considering measures for control of cancer and other non-communicablediseases. Liver cancer is consistently found at higher incidence than most other parts of Asia, with lung canceras the other most important neoplasm in males. In females cervical and breast cancer about equally predominate,throughout. However, there are also major differences, particularly with regard to stomach and nasopharyngealcancer, only found at relatively high incidence in Viet Nam. The present review was conducted to gather togetherregistry data on cancer prevalence and epidemiological findings cited in PubMed in order to obtain ascomprehensive picture as possible of the present status. It is hoped that future cooperation across the region willfacilitate development of coordinated cancer control programs to reduce the burden.