Squamous Cell Carcinoma Antigen and Cancer Antigen 125 in Southern Indian Cervical Cancer Patients


Our objective was to evaluate the diagnostic value of squamous cell carcinoma antigen (SCC-ag) and cancerantigen (CA) 125 serum tumor markers for the detection of cervical cancer. Abnormal SCC-ag(>1.5 ng/mL) andCA125 (>35 U/mL) levels were found in 64.2% and 18.9% of a series of SCC patients and in 25.0% and 42.6%of adenocarcinoma (AC) patients. The SCC-ag and CA 125 markers appeared rather specific for cervical SCCsand ACs, respectively, also correlating with clinical stage and lymph node metastasis, but not tumor size orpatient age. In conclusion, SCC-ag and CA 125 are useful and reproducible markers for advanced stage diseaseand thus prognosis of cervical cancer.