The lung is the most frequent metastatic site of hepatocellular carcinoma (HCC), negatively impactingon survival rates. In this study, we evaluated the prognostic role of the chemokine receptor CXCR7 in lungmetastasis of HCC after hepatectomy, using immunohistochemical detection on tissue microarrays of HCCs,with and without lung metastasis. Using three categories based on staining characteristics, patients with highCXCR7 expression demonstrated a shorter time to development of lung metastasis compared with patients withlow CXCR7 expression (log-rank test) with no effet on overall survival. Analysis of tissue adjacent to tumorshowed patients with microvascular invasion to have higher CXCR7. Stratification based on alpha fetoproteinlevel >20 ng/ml also showed high expression of CXCR7 to be a strong independent prognostic factor. Thesefindings suggest that high expression of CXCR7 in HCCs with elevated alpha fetoprotein levels correlates withmetastasis to lung and poor survival after hepatectomy, indicating potential use as a prognostic factor.