Hexavalent chromium Cr (VI) used in shielded metal arc welding is widely recognized to act as a carcinogen,mutagen and teratogen. The carcinogenic potential of metals is a major issue in defining human health riskfrom exposure. Hence in the present investigation, 66 welders and 60 control subjects with similar mean ages,smoking prevalences and alcohol consumption were enrolled for DNA damage analysis of buccal cells bymicronucleus (MN) and comet assay. Welders showed a significant increase in micronucleated cells comparedto controls and a larger mean comet tail length. The current study thus suggested that chronic occupationalexposure to Cr (VI) during welding could lead to increased level of DNA damage. Understanding the complexityof the relationshipsbetween exposure, basal DNA damage and MN frequencies requires larger scale studies andapplication of complementary biomarkers.