Lack of Association Between GSTM1 and GSTT1 Polymorphisms and Brain Tumour Risk


Objective: Glutathione S-transferases (GSTs) are important enzymes that are involved in detoxification ofenvironmental carcinogens. Molecular epidemiological studies have been conducted to investigate the associationbetween GSTM1 and GSTT1 homozygous deletion polymorphisms and brain tumours but results have beenconflicting. The aim of this study was to clarify this problem using a meta-analysis.
Methods: A total of 9 recordswere identified by searching the PubMed and Embase databases. Fixed- and random-effects models wereperformed to estimate the pooled odds ratios.
Results: No significant association was found between the GSTM1and GSTT1 homozygous deletion polymorphisms and risk of brain tumours, including glioma and meningioma.Similar negative results were also observed in both population-based and hospital-based studies.
Conclusion:These findings indicate that the GSTM1 and GSTT1 polymorphisms may not be related to the development ofbrain tumours.