Objectives: To obtain permeability surface (PS) values using multi-slice helical CT perfusion imagingand to evaluate the spatial distribution correlation between PS values and vascular endothelial growth factor(VEGF) expression in solitary brain metastases. Methods: Imaging was performed on 21 patients, PS valuesbeing calculated from the central, border and peripheral parts of tumours. VEGF expression was determinedby immunohistochemical staining. Results: Rim enhancement was found in 16 cases, the border of the tumourfeaturing PS elevation with high VEGF expression in 13 cases. In the 5 cases with nodular enhancement, theborder and the central part had high permeability and VEGF expression was high in all cases, the correlationbeing significant (P<0.01) . Conclusion: VEGF expression in brain metastases positively correlates with PS valuesfrom CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brainmetastases.
(2012). Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases. Asian Pacific Journal of Cancer Prevention, 13(4), 1575-1578.
MLA
. "Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases". Asian Pacific Journal of Cancer Prevention, 13, 4, 2012, 1575-1578.
HARVARD
(2012). 'Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases', Asian Pacific Journal of Cancer Prevention, 13(4), pp. 1575-1578.
VANCOUVER
Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases. Asian Pacific Journal of Cancer Prevention, 2012; 13(4): 1575-1578.
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