Objective: To investigate liver fibrosis, TGF-β1 levels and curative effects on hepatocellular carcinoma (HCC)with small and conventional dose perfusion chemotherapy by transcatheter arterial chemo embolization (TACE).
Methods: Thirty-six hepatocellular carcinoma patients not indicated for surgical resection underwent superselectivetranscatheter arterial chemoembolization, divided into small dose (n=15) and conventional dose (n=21)chemotherapy groups.
Results: With conventional doses, four indices of liver fibrosis focusing on hyaluronateacide (HA), human procollagen type-Ⅲ (hPC-Ⅲ), collagen type-Ⅳ (Ⅳ-C) and transforming growth factor-βl(TGF-β1) were obviously increased postoperative compared with preoperative (P<0.01); in contrast, with smalldoses there were no significant differences except for TGF-β1. Five year survival demonstrated no significantdifferences between the two groups (P>0.05).
Conclusion: To hepatocellular carcinoma patients treated byTACE, reducing doses of chemotherapy drugs can reduce progress of liver fibrosis, without impacting on fiveyear survival.