The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

Abstract


Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer(BC).
Methods: Electronic searches of several databases were conducted for all online publications. A total of 7studies involving 4,625 BC patients and 4,373 controls were identified.
Results: This meta-analysis showed nosignificant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations.However, a positive association was found limited to Asian populations.
Conclusion: Although there was nosignificant association found between the LTA-252 A>G polymorphism and BC overall, a positive associationwas found in Asian populations.

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