Reproductive Variables and Risk of Breast Malignant and Benign Tumours in Yunnan Province, China


Introduction and aim: To compare reproductive factor influence on patients with pathological diagnosedmalignant and benign tumor in the Breast Department, The First Peoples’ Hospital of Kunming in Yunnanprovince, China.
Methods: A hospital-based case-control study was conducted on 263 breast cancer (BC) casesand 457 non-breast cancer controls from 2009 to 2011. The cases and controls information on demographics,medical history, and reproductive characteristics variables were collected using a self-administered questionnaireand routine medical records. Histology of breast cancer tissue and benign breast lesion were documented bypathology reports. Since some variables in data analysis had zero count in at least one category, binomial-responseGLM using the bias-reduction method was applied to estimate OR’s and their 95% confidence intervals (95%CI). To adjust for age and menopause status, a compound variable comprising age and menopausal status wasretained in the statistical models.
Results: multivariate model analysis revealed significant independent positiveassociations of BC with short menstrual cycle, old age at first live birth, never breastfeeding, history of oralcontraception experience, increased number of abortion, postmenopausal status, and nulliparity. Categorisedby age and menopausal status, perimenopausal women had about 3-fold and postmenopausal women had morethan 5-fold increased risk of BC compared to premenopausal women. Discussion and
Conclusion: This study hasconfirmed the significant association of BC and estrogen related risk factors of breast cancer including longermenstrual cycle, older age of first live birth, never breastfeeding, nulliparity, and number of abortions morethan one. The findings suggest that female hormonal factors, especially the trend of menopause status play asignificant role in the development of BC in Yunnan women