Serum Amyloid A as an Independent Prognostic Factor for Renal Cell Carcinoma - A Hospital Based Study from the Western Region of Nepal


Objective: The objective of our present study was to assess the role of serum amyloid A (SAA) in stages andprognosis of renal cell carcinoma. Material and
Methods: It was a hospital based retrospective study carriedout in the Department of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal between1st January 2008 and 31st December 2011. The variables collected were SAA, CRP. Approval for the study wasobtained from the institutional research ethical committee. Quantitative analysis of human SAA and C-reactiveprotein (CRP) was performed by radial immune diffusion (RID) assay for all cases.
Results: Of the 422 total casesof renal cell carcinoma, 218 patients had normal and 204 abnormal SAA. SAA levels were grossly elevated in T3stage (122.3 ± SD35.7) when compared to the mean for the T2 stage (84.2 ± SD24.4) (p value: 0.0001). Similarly,SAA levels were grossly elevated in M1 stage (190.0 ± SD12.7) when compared to the M0 stage (160.9±SD24.8)(p: 0.0001). There was no significant association with elevated CRP levels (209.1 ± SD22.7, normal 199.0 ±SD19.5) .
Conclusion: The validity of SAA in serum as being of independent prognostic significance in RCC wasdemonstrated with higher levels in advanced stage disease.