Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine which plays roles in inflammation,immune responses and cancer development. It assists macrophages in carrying out functions like phagocytosis,adherence and motility. Of late, MIF is implicated in almost all stages of neoplasia and expression is a feature ofmost types of cancer. The presence of MIF in almost all tumors and all stages of cancer makes it an interestingcandidate for cancer therapy. This review explores the roles of MIF in neoplasia.