Objective: To determine STAT3, P-STAT3, and VEGF-C expression levels in small cell lung cancers (SCLCs),and discuss their role and clinical significance in SCLC development. Method: Immunohistochemical methodswere applied to 128 cases of SCLC and 40 cases of adjacent normal tissue. Results: The expression levels ofSTAT3, P-STAT3, and VEGF-C were higher in SCLC than in normal tissue (P < 0.05). Pairwise comparisonsshowed positive correlations with lymph node metastasis, clinical stage, and tumor size (P <0.05). The expressionlevels were also related with the overall survival rates. Conclusion: STAT3 and VEGF-C play important rolesin the development of SCLC, and might be expected to become new targets for SCLC treatment.
(2012). Expression and Clinical Significance of STAT3, P-STAT3, and VEGF-C in Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention, 13(6), 2873-2877.
MLA
. "Expression and Clinical Significance of STAT3, P-STAT3, and VEGF-C in Small Cell Lung Cancer". Asian Pacific Journal of Cancer Prevention, 13, 6, 2012, 2873-2877.
HARVARD
(2012). 'Expression and Clinical Significance of STAT3, P-STAT3, and VEGF-C in Small Cell Lung Cancer', Asian Pacific Journal of Cancer Prevention, 13(6), pp. 2873-2877.
VANCOUVER
Expression and Clinical Significance of STAT3, P-STAT3, and VEGF-C in Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention, 2012; 13(6): 2873-2877.
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