Assessment of Biochemical Profiles in Premenopausal and Postmenopausal Women with Breast Cancer


Objective: The study was conducted to assess biochemical profiles in premenopausal and postmenopausalwomen having breast cancer. Materials and
Methods: A hospital based case control study was carried outat Manipal Teaching Hospital (MTH), Pokhara, Nepal. The analysed variables were age, metabolic profileincluding total cholesterol, triglycerides, HDL-C, LDL-C, blood sugar, insulin concentration, C-peptide, HbA1cand selenium. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO andSPSS 16 software.
Results: In premenopausal women, significant differences were noted for total cholesterol (Pvalue <0.001), triglycerides (P value 0.002), HbA1c level (P value <0.001), insulin concentration (P value 0.030),C-peptide concentration (P value 0.001), and selenium (P value <0.001) between cases and controls. Insignificantresults were found for HDL-C (P value 0.749), LDL-C (P value 0.933), blood sugar (P value 0.59) and BMI (Pvalue 0.746). Similarly, significant difference in total cholesterol (P value <0.001), triglycerides (P value 0.001),LDL-C (P value <0.001), HDL-C (P value 0.025), blood sugar (P value <0.001), insulin concentration (P value<0.001), c-peptide concentration (P value <0.001), HbA1c level (P value <0.001) and selenium (P value <0.001)were observed for postmenopausal patients and controls.
Conclusions: Assessing metabolic changes and theirmanagement may be important for control of breast cancer and increased survival.