Variants on ESR1 and their Association with Prostate Cancer Risk: A Meta-analysis

Background: Epidemiological studies evaluating the association of two variants rs9340799 and rs2234693 onestrogen receptor 1 (ESR1) with prostate risk have generated inconsistent results.
Methods: A meta-analysis washere conducted to systematically evaluate the relationship of these two variants with prostate cancer susceptibility.
Results: For rs9340799, heterozygosity of T/C carriers showed a significant increased prostate cancer risk with apooled odds ratio (OR) of 1.34 (95% CI = 1.06-1.69) while homozygote C/C carriers showed an increased but notstatistically significant association with prostate cancer risk (pooled OR = 1.29, 95% CI = 0.94-1.79). Comparedto the homozygous TT carriers, the allele C carriers showed a 31% increased risk for prostate cancer (pooledOR = 1.31, 95% CI = 1.06-1.63). No significant association between the rs2234693 and prostate cancer riskwas found with the pooled OR of 1.15 (95% CI = 0.97-1.39, T/C and C/C vs. T/T) under the dominant geneticmodel. Compared to the homozygote T/T carriers, the heterozygous T/C carriers did not show any significantlydifferent risk of prostate cancer (pooled OR = 1.13, 95% CI = 0.94-1.36) and the homozygous C/C carriers alsodid not show a significant change for prostate cancer risk compared to the wide-type T/T carriers (pooled OR= 1.26, 95% CI = 0.98-1.62).
Conclusions: These data suggested that variant rs9340799, but not rs2234693, onESR1 confers an elevated risk of prostate cancer.