Preliminary Study of Protective Effects of Flavonoids against Radiation-induced Lung Injury in Mice

Background: Radiation therapy plays an important role in lung carcinoma treatment. However, the incidenceof symptomatic radiation-induced lung injury is high. This study aimed to evaluate radioprotective effects offlavonoids extracted from Astragalus complanatus and mechanisms of action against radiation damage.
Methods:Alteration in antioxidant status and levles of several cytokines were investigated in BABL/C mice treatedwith 4 mg/kg b.wt. flavonoids after exposure to 10Gy thoracic radiation.
Results: Serum levels of SOD in theflavonoids+radiation group were significantly higher compared to the radiation control group, while TGF-β1and IL-6 were lower. Mice in the radiation control group displayed more severe lung damage compared with theflavonoids+radiation group. The expression of TGF-β1 and TNF-α in the radiation control group was markedlyincreased in alveolar epithelial cells and macrophages of the alveolar septum.
Conclusions: From the results ofthe present study, flavonoids could be excellent candidates as protective agents against radiation-induced lunginjury.