Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies


Background: Many studies have investigated associations between the glutathione S-transferase M1 (GSTM1)null polymorphism and risk of prostate cancer, but the impact of GSTM1 in people who live in Asian countries isstill unclear owing to inconsistencies across results.
Methods: We searched the PubMed, Web of Science, Scopus,Ovid and CNKI databases for studies of associations between the GSTM1 null genotype and risk of prostatecancer in people who live in Asian countries, and estimated summary odds ratios (ORs) with 95% confidenceintervals (95% CIs).
Results: A total of 18 case-control studies with 2,172 cases and 3,258 controls were includedin this meta-analysis, which showed the GSTM1 null genotype to be significantly associated with increased riskof prostate cancer in people who live in Asian countries (random-effects OR=1.74, 95% CI1.44-2.09, P<0.001).Similar results were found in East Asians (OR=1.41; 95% CI: 1.12–1.78; P=0.004) and Caucasians in Asia(OR=2.19; 95% CI: 1.85-2.60; P<0.001). No evidence of publication bias was observed.
Conclusions: This metaanalysisof available data suggested that the GSTM1 null genotype does contribute to increased risk of prostatecancer in people who live in Asian countries.