Serum Hepatitis a Antibody Positivity Correlates with Higher Pancreas Cancer Mortality in Adults: Implications for Hepatitis Vaccination in High Risk Areas


Background: This study used pre-hepatitis A vaccination era data in U.S. to study the relationship betweenserum hepatitis A antibody positivity with pancreas cancer mortality in adults. Patients and
Methods: Publicuse National Health and Nutrition Examination Survey (NHANES III) data were employed. NHANES III usescomplex probabilistic methods to sample nationally representative samples. Household adult laboratory andmortality data were merged. Sample persons who were available to be examined in the Mobile ExaminationCenter (MEC) were included in this study. All results were obtained by using specialized survey software takinginto account the primary sampling unit and stratification variables and the weights assigned to the sample personsexamined in the MEC. Thus they are representative of the U.S. population.
Results: The mean risk (95%CI)of death in the study population for pancreas cancer was 0.0014 (-0.000069 -.0029); their mean age (95%CI)at the mobile examination center (MXPAXTMR) was 473.43 (463.85-482.10); the follow up in months fromtheir medical examination (permth_exm) was 170.12 (164.17-176.07). The odds ratios (S.E.) of the statisticallysignificant univariables were: age, 1.007 (1.005-1.009); serum anti-hepatitis antibody status, 0.038 (0.004-0.376);and drinking hard liquor, 1.014 (1.004-1.023). The coefficients (S.E.) of the statistically significant variablesafter multivariate analysis were 0.006 (0.002-0.010) for age and -2.528 (-4.945--0.111) for serum anti-hepatitis Aantibody negativity (using serum anti-hepatitis A antibody positivity as a reference).
Conclusion: Serum hepatitisA antibody positivity correlates with higher pancreas cancer mortality in adults.