Tissue Expression, Serum and Salivary Levels of IL-10 inPatients with Head and Neck Squamous Cell Carcinoma


Background: Head and neck SCC is a common cancer related to various factors. IL-10, a pleiotropic cytokineproduced by macrophages, T-helper-2 cells, and B lymphocytes, is thought to play a potential pathogenetic ortherapeutic role in a number of human conditions, such as inflammation, autoimmunity and cancer. The presentstudy was designed to evaluate the relation between tissue expression, serum and salivary levels of IL-10 in headand neck squamous cell carcinomas (HNSCCs) and their correlation with clinicopathologic features. Materialsand
Methods: Samples were collected from 30 patients with HNSCCs and 24 healthy volunteers. IHC analysiswas used to examine the tissue expression and ELISA was employed to measure serum and salivary levels.
Results: Our study showed tissue expression of IL-10 to be significantily higher in patients (P: 0.001), but therewas no relation between tissue expression , serum and salivary levels of the marker (P>0.05). Also except for apositive correlation between tissue expression of IL-10 and stage (P: 0.044), there was no relation between thismarker and clinicopathologic features. There was no correlation between serum and salivary levels in eitherpatients or controls.
Conclusions: It seems there is no correlation between level of IL-10 in serum and salivaand this marker in saliva and serum does not reflect tissue expression.