The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include threesubtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in thedifferentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showedthat Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis inducedby As2O3 through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetradecanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role inthe occurrence and development of AML.