Cancer Preventive Effects of Whole Cell Type Immunization against Mice Ehrlich Tumors

Abstract

Background: Effects of whole cell type immunization on mice Ehrlich tumours were evaluated. Materialsand
Methods: After preliminary study, mice were divided two major groups; 1x1000 and 100x1000 live Ehrlichcell transferred major groups, each divided into four subgroups (n: 10). Study groups were immunized withEhrlich cell lysates in 0, 3, 7, 14th days and after 30 days of last immunization, live Ehrlich cells were transferred.Mice were observed for six months and evaluated for total and cancer free days.
Results: Out of 100x1000 celltransferred solid type study group, all study group mean and tumour free periods were statistically longer thancontrol groups. All 1x1000 Ehrlich cell transferred study groups survived significantly longer than 100x1000Ehrlich cell transferred groups.
Conclusions: Ehrlich mice tumours were prevented and survival prolongedwith whole cell type immunization. Effects are related to the number of transferred tumor cells.

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