Multidisciplinary Collaborative Therapy for 30 Children with Orbital Rhabdomyosarcoma


Objective: To explore clinical experience and propose new ideas for treating children diagnosed withorbital rhabdomyosarcoma (RMS).
Methods: We retrospectively analyzed the clinical data for30 patients (16males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in theDepartment of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012. InternationalRhabdomyosarcoma Organization Staging Standards indicated that among the 30 patients, 4 cases were in phaseII, 20 were in phase III, and 6 were in phase IV. All patients underwent a multidisciplinary collaborative model ofcomprehensive treatment (surgery, chemotherapy, external radiotherapy, 125I radioactive particle implantation,and autologous peripheral blood stem-cell transplantation).
Results: Follow-up was conducted until March 2013,with a median follow-up time of 47.2 months (5 to 95 months), and 7 deaths occurred. The 2-year estimatedsurvival rate reached 86.1%, the ≥3-year estimated survival rate was 77%, and the 5-year estimated survivalrate was 70.6%.
Conclusions: The multidisciplinary collaborative model can be a safe and effective approach tothe comprehensive treatment of children with orbital RMS. It has clinical significance in improving the tumorremission rate.