The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeatcontaining G-protein coupled receptor 48 (GPR48) plays an important role in multiple organ development. Inthe present study, we investigated whether GPR48 functions in cancer cells using MCF-7, HepG2, NCI-N87and PC-3 cells. We found that GPR48 overexpression promotes while its knockdown using small interferingRNA oligos inhibits cell proliferation. In addition, Wnt/β-catenin signaling was activated in cells overexpressingGPR48. Therefore, our results indicated that GPR48 activates Wnt/β-catenin signaling to regulate cancer cellproliferation.
(2013). GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling. Asian Pacific Journal of Cancer Prevention, 14(8), 4775-4778.
MLA
. "GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling". Asian Pacific Journal of Cancer Prevention, 14, 8, 2013, 4775-4778.
HARVARD
(2013). 'GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling', Asian Pacific Journal of Cancer Prevention, 14(8), pp. 4775-4778.
VANCOUVER
GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling. Asian Pacific Journal of Cancer Prevention, 2013; 14(8): 4775-4778.
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