GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling


The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeatcontaining G-protein coupled receptor 48 (GPR48) plays an important role in multiple organ development. Inthe present study, we investigated whether GPR48 functions in cancer cells using MCF-7, HepG2, NCI-N87and PC-3 cells. We found that GPR48 overexpression promotes while its knockdown using small interferingRNA oligos inhibits cell proliferation. In addition, Wnt/β-catenin signaling was activated in cells overexpressingGPR48. Therefore, our results indicated that GPR48 activates Wnt/β-catenin signaling to regulate cancer cellproliferation.